Keywords: Paratuberculosis; Gene; ITK; Johne's disease;
مقالات ISI (ترجمه نشده)
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Keywords: ASH; American Society of Hematology; ATAP; amphipathic tail-anchoring peptide; BAD; BCL-2-associated death promoter protein; BAK; BCL-2 homologous antagonist killer; BAX; BCL-2-associated X protein; BCL-2; B-cell lymphoma 2; BCL-w (BCL2L2); BCL-2-like pro
Keywords: VEGF; Vascular Endothelial Growth Factor; MMP; Matrixmetalloproteinases; uPAR; UrokinasePlasminogen Activator Receptor; Ang-1; Angiotensin-1; TGF-β; Transforming Growth Factor-β; VEGFR; Vascular Endothelial Growth Factor Receptor; TKI; Tyrosine Kinase I
Keywords: Silicon radiation detectors; Strip sensors; HL-LHC; ATLAS upgrade; ITk; Pitch adapters;
Keywords: Fusion; Image registration; MRI; X-ray; Cardiac resynchronization therapy; 2D; Two dimensions; 2DTRE; Two dimensional target registration error; 3D; Three dimensions; 3DTRE; Three dimensional target registration error; AHA; American heart association; CMR
Keywords: BTK; Bruton tyrosine kinase; CGD; chronic granulomatous disease; CMC; chronic mucocutaneous candidiasis; γc; γ-common; HLH; hemophagocytic lymphohistiocytosis; HSCT; hematopoietic stem cell transplantation; ITK; IL2-inducible T cell kinase; NK; natural
Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression
Keywords: Chimeric tyrosine kinases; Fusion genes; ITK; SYK; FER; Oncogenes;
A lightweight rapid application development framework for biomedical image analysis
Keywords: Scientific Visualization; SMILI; Biomedical Software; Image Analysis; FAI; Cam Lesions; ITK; VTK;
A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1
Keywords: Slingshot; Cofilin; Pleckstrin homology (PH) domain; Actin binding; Phosphatase; Btk; Bruton's tyrosine kinase; CD; circular dichroism; CFP; cyan fluorescent protein; Itk; interleukin-2-inducible T-cell tyrosine kinase; LHK motif; Leu-His-Lys motif; OSBP;
Interleukin-2-inducible T-cell kinase expression and relation to disease severity in systemic lupus erythematosus
Keywords: Lupus; ITK; Th17; Treg;
Modulation of TCR responsiveness by the Grb2-family adaptor, Gads
Keywords: DAG; diacylglycerolDSB, double strand break; Gads; Grb2-related adaptor downstream of Shc; Indel; insertion and deletion mutation; GFP; green fluorescent protein; Grap; Grb2-related adaptor protein; Grb2; growth factor receptor-bound 2; IRES; internal rib
The role of CRAC channel in asthma
Keywords: Asthma; Lymphocytes; CRAC channel; Orai channels NF-AT; ACQ; asthma control questionnaire; BAL; bronchoalveolar lavage; CRAC; calcium released activated channel; Dex; dexamethasone; ELISA; enzyme linked immunosorbent assay; FEV; forced expiratory volume;
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors
Keywords: SBDD; ITK; Indazole; X-ray crystallography; Ï-stacking;
Le passage transplacentaire des médicaments
Keywords: placenta; médicaments; modèles in vitro; perfusion placentaire; transporteurs; placenta; drugs; in vitro models; placental perfusion; transporters; ABC; adenosine triphosphate-bindingcassette; AGA; α-1 glycoprotéine acide; AMM; autorisation de mise su
Pharmacologie du phénomène de Raynaud
Keywords: phénomène de Raynaud; inhibiteurs calciques; iloprost; antagonistes des récepteurs de l'endothéline; inhibiteurs de la phosphodiestérase-5; Raynaud'sphenomenon; calcium channel blockers; iloprost; endothelin receptor antagonists; phosphodiesteras
MBIS: Multivariate Bayesian Image Segmentation tool
Keywords: 62P10; 62F15Multivariate; Reproducible research; Image segmentation; Graph-cuts; ITK
Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through β-sheet formation
Keywords: βME; β-mercaptoethanol; CrkL; Crk-like; DTT; dithiothreitol; Itk; interleukin-2 tyrosine kinase; SLAP; Src-like adaptor protein; SFK; Src family kinase; SH; Src-homology; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; TCR; T cell r
Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization
Keywords: ITK; Interleukin 2-inducible T cell kinase; Gag; HIV-1 group-specific antigen; MVB; multivesiclar bodies; VSV-G; vesicular stomatitis virus glycoprotein; PLAP; placental alkaline phosphatase; VLP; virus like particles; HIV; ITK; Tec kinases; Gag; Actin; V
Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis
Keywords: 7-AAD; 7-amino-actinomycin D; Atf2; activating transcription factor 2; Csk; C-terminal Src kinase; Erk; extracellular-signal-regulated kinase; FCB; fluorescent cell barcoding; FSC; forward scatter; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IL-2; in
Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation
Keywords: Primary immunodeficiency; T-cell immunodeficiency; severe combined immune deficiency; EBV-associated B-cell lymphoproliferation; thymus; invariant natural killer T cell; mucosal-associated invariant T cell; EBER; EBV-encoded small RNA in situ hybridizatio
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
Keywords: GBDUVEXHPMNVRW-UHFFFAOYSA-N; UJXIKUVGGQECLJ-UHFFFAOYSA-N; FVSUKLKFSDSIEF-UHFFFAOYSA-N; OHAIFZDRLDEOAC-UHFFFAOYSA-N; PVCKRSKEOOWVMP-UHFFFAOYSA-N; LXMWGYNOGUKODT-UHFFFAOYSA-N; CQZZZUNOWZUNNG-UHFFFAOYSA-N; YBKODNZGBUDZRA-UHFFFAOYSA-N; Itk; interleukin-2-indu
Perspectives des thérapies ciblées dans le cancer du sein métastatique
Keywords: thérapie ciblée; cancer du sein métastatique; HER-2; anti-angiogénèse; étude clinique; targeted therapy; metatstatic breast cancer; HER-2; anti-agiogenesis; clinical trial; ADCC; cytotoxicité à médiation cellulaire anticorps-dépendante; Akt; pro
Primary immunodeficiency diseases associated with increased susceptibility to viral infections and malignancies
Keywords: Immunodeficiency; viral infection; malignancies; X-linked lymphoproliferative syndrome; AR-HIES; Autosomal recessive hyper-IgE syndrome; CVID; Common variable immunodeficiency; DDR; DNA damage response; DOCK8; Dedicator of cytokinesis 8; EV; Epidermodyspl
Identification of potent ITK inhibitors through focused compound library design including structural information
Keywords: ITK; Interleukin-2 inducible T cell kinase; ITK inhibitors; Library design; Kinases; Drug design; Docking; Crystal structure; X-ray; Lead finding; Lead optimisation; Focused kinase library; Ligand efficiency
The Src, Syk, and Tec family kinases: Distinct types of molecular switches
Keywords: Syk; Zap-70; Btk; Itk; Kinase; Switch
Synthesis and biological evaluation of novel (4 or 5-aryl)pyrazolyl-indoles as inhibitors of interleukin-2 inducible T-cell kinase (ITK)
Keywords: ITK; Interleukin-2 inducible T-cell kinase; Tec kinase; Pyrazolyl-indole
5-Aminomethylbenzimidazoles as potent ITK antagonists
Keywords: ITK; Interleukin-2 inducible T-cell kinase; 5-Aminobenzimidazole
Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design
Keywords: Kinase; Structure-based drug design; ITK; Tec kinase; SAR; Inhibitor; Benzimidazole
PKCθ and Itk functionally interact during primary mouse CD3+ T cell activation
Keywords: PKCθ; Itk; T cells; Gene ablation; Pharmacological inhibition
Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets
Keywords: HIV-1; Bortezomib; Proteasome inhibitor; NF-κB; Itk; LTR; Transcription
2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket
Keywords: ITK; T-cell kinase; Aminobenzimidazoles; Inflammation; Kinase specificity pocket
Bacterial expression and purification of Interleukin-2 Tyrosine kinase: Single step separation of the chaperonin impurity
Keywords: Kinase; Bacterial expression; Purification; Chaperonin; Itk; Lck; Src
Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)
Keywords: SAR; Itk; Inhibitor; Benzimidazole
Preventing facial recognition when rendering MR images of the head in three dimensions
Keywords: Facial recognition; 3D rendering; Mathematical morphology; MRI; ITK
Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors
Keywords: ITK; Kinase; Kinase inhibitor; Benzimidazole; Inducible T cell kinase
Integrating digital topology in image-processing libraries
Keywords: Digital topology; Image-processing library; ITK; Code genericity
A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9
Keywords: Tim-3; Tim-1; Kim-1; HAVcr; Galectin-9; SH2; ITK; T-cells; Atopy
An efficient and generic extension to ITK to process arbitrary shaped regions of interest
Keywords: Medical image processing; Regions of interest; Code reusability; ITK
Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5q33
Keywords: Atopy; asthma; eczema; TIM; ITK; polymorphisms; CRSP9; cofactor required for Sp1 transcriptional activation, subunit 9; HAV; Hepatitis A virus; ITK; IL-2-inducible T-cell kinase; LD; Linkage disequilibrium; RR; Relative risk; SNP; Single nucleotide poly
Efficient multi-modal dense field non-rigid registration: alignment of histological and section images
Keywords: ITK; Non-rigid registration; Elastic regularization; Mutual information; Laryngectomy;
Differential expression and molecular characterisation of Lmo7, Myo1e, Sash1, and Mcoln2 genes in Btk-defective B-cells
Keywords: Xid; XLA; Btk; Itk; Tec; Bmx; Lmo7; Myo1e; Sash1; Mcoln2;
The Medical Imaging Interaction Toolkit
Keywords: ITK; Interaction; Visualization; Toolkit; VTK;