دانلود مقالات ISI درباره Ivive + ترجمه فارسی

روش پیش بینی مبتنی بر مسیر برای ارزیابی غیر حیوانات از سمیت استنشاق حاد

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

Keywords: Acute inhalation toxicity; In vitro; In silico; Ex vivo; Quantitative structure-activity relationships (QSAR); Adverse outcome pathway; Aggregate exposure pathway; Dosimetry; Integrated approach to testing and assessment (IATA); Risk assessment; ADME; abs

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

بحث بر روی مدل کبد به خوبی همزاد: مجدد مجدد از مدل پراکندگی و دوباره تجزیه و تحلیل داده های لیدوکائین

Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data

Keywords: AAG; α1-acid glycoprotein; IPRL; isolated perfused rat liver; IVIVE; in vitro-in vivo extrapolation; PBPK; physiologically based pharmacokinetic(s); PK; pharmacokinetic(s); Pharmacokinetics; Well-stirred model; Parallel-tube model; Dispersion model; Hepa

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

مطالعات متابولیسم آفت کش های شیمیایی: بررسی انتقادی

Metabolism studies of chiral pesticides: A critical review

Keywords: AUC; area under the concentration-time curve; BN; benalaxyl; CE; capillary electromigration techniques; CL; clearance; CLH; hepatic clearance; CLint; intrinsic clearance; DC; diclofop; DM; diclofop-methyl; DN; diniconazole; E; hepatic extraction rate; ET;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

شناسایی جمعیت های حساس به مواد شیمیایی محیطی با شبیه سازی تنوع سمی و کینتیک

Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability

Keywords: EPA; Environmental Protection Agency; HTS; High-Throughput Screening; IVIVE; in vivo-in vitro extrapolation; OED; Oral equivalent dose; AER; Activity:Exposure ratio; TK; Toxicokinetics; HTTK; High Throughput TK; NHANES; National Health and Nutrition Exami

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

محدودیت ها، ساخت و تایید یک مدل موش مبتنی بر فیزیولوژیک مبتنی بر فاکتوریل

The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model

Keywords: preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

پیش بینی کالری کبدی از مهارکننده های پروتئاز ویروس نقص ایمنی بدن انسان در موش صحرایی

Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat

Keywords: in vitro/in vivo correlations (IVIVC); hepatic clearance; hepatic metabolism; hepatic transport; transporters; drug transport; drug metabolizing enzymes; HIV/AIDS; FBS; fetal bovine serum; HEPES; 4-(2-hydroxyethyl)-1- piperazine ethanesulfonic acid; HIV

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

کاربرد مدلسازی فارماکوکینتیک مبتنی بر فیزیولوژیک برای بررسی نقش کانالهای کلیه در جذب کلیه اسید پرفلووروکاتانیک در موش صحرایی

Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat

Keywords: PFOA; PBPK; Oatp1a1; Oat1; Oat3; IVIVE

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Development of a human physiologically based pharmacokinetic (PBPK) model for phthalate (DEHP) and its metabolites: A bottom up modeling approach

Keywords: DEHP; MEHP; Pharmacokinetics; PBPK; Human health risk assessment; IVIVE; Endocrine disruptors; Human biomonitoring;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment

Keywords: 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis

Keywords: Glucocorticoid receptor; Adipogenesis; Obesogen; ToxCast; IVIVE; Chemical prioritization;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum

Keywords: Physiologically-based kinetic (PBK) modelling; Hazard and risk assessment; Weight-of-evidence (WoE); Threshold of toxicological concern (TTC); In vitro to in vivo extrapolation (IVIVE); Integrated approach for testing and assessment (IATA); Absorption; Di

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism

Keywords: albumin-mediated uptake; clearance; DDI; drug interaction; hepatocytes; IVIVE; IPRL; pharmacokinetics; PBPK models;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

Keywords: AUC; area under the curve; DDI; drug-drug interaction; fu; fraction unbound; IC50; inhibition constant; IV; intravenous; IVIVE; in vitro/in vivo extrapolation; Ki; inhibition constant; OAT; organic anion transporter; PBPK; physiologically based pharmacoki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation

Keywords: Drug-drug interactions; CYP2D6; Bupropion; Enzyme regulation; In vitro to in vivo extrapolation; AUC; area under plasma concentration time curve; CYP; cytochrome P450; DDI; drug-drug interaction; fm; fraction metabolized; IVIVE; in vitro to in vivo extrap

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Theoretical and mathematical foundation of the Virtual Cell Based Assay - A review

Keywords: Virtual Cell Based Assay (VCBA); Chemical fate; Intracellular concentration; In vitro; In silico; IVIVE;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Keywords: drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches

Keywords: active transport; cytochrome P450; glucuronosyltransferase (UGT); hepatic clearance; hepatic transport; hepatocytes; membrane transport/transporters; organic anion transporting polypeptide transporters; transporters; AUC; area under the plasma concentrati

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates With Estrone-3-Sulfate Transport in Caco-2

Keywords: Caco-2 cells; proteomics; liquid chromatography; mass spectrometry; intestinal absorption; efflux pumps; ABC transporters; ABC; ATP-dependent binding cassette; BCRP; breast cancer resistance protein; BSA; bovine serum albumin; E-3-S; estrone-3-sulfate; HB

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research

Keywords: ADME; clearance; disposition; distribution; hepatocytes; IVIVE; partition coefficients; pharmacokinetics; pharmacodynamics; PKPD;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

A case study on quantitative in vitro to in vivo extrapolation for environmental esters: Methyl-, propyl- and butylparaben

Keywords: Methylparaben; Propylparaben; Butylparaben; IVIVE; PBPK;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment

Keywords: TT21C; AOP; Risk assessment; IVIVE; Quercetin; p53;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: A case study of lindane-induced neurotoxicity

Keywords: MEA; microelectrode array; PBPK; physiologically based pharmacokinetic; IVIVE; in vitro to in vivo extrapolation; GC-μECD; gas chromatograph micro electron capture detector; GABA; γ-aminobutyric acid; EC50; effective concentration 50%; RSD; relative sta

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds

Keywords: IVIVE; In vitro metabolism; Reverse dosimetry; Css;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies

Keywords: distribution; hepatocytes; liver; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Prediction of Total Hepatic Clearance by Combining Metabolism, Transport, and Permeability Data in the In Vitro-In Vivo Extrapolation Methods: Emphasis on an Apparent Fraction Unbound in Liver for Drugs

Keywords: hepatocytes; intrinsic clearance; unbound fraction; metabolism; transport; permeability; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data

Keywords: hepatocytes; intrinsic clearance; unbound fraction; computational ADME; in vitro–in vivo extrapolation; in vitro–in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux

Keywords: P-glycoprotein; ABCB1; MDR1; simulation; digoxin; IVIVE; pharmacokinetics; transporter

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro-in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans

Keywords: In vitro; Kinetic modeling; Bayesian; PBPK; IVIVE;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

In Vitro-In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods

Keywords: disposition; microsomes; hepatic clearance; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Development of a Physiologically Based Pharmacokinetic Model for the Rat Central Nervous System and Determination of an In Vitro-In Vivo Scaling Methodology for the Blood-Brain Barrier Permeability of Two Transporter Substrates, Morphine and Oxycodone

Keywords: BBB; blood-brain barrier; Caco-2 cells; CNS; IVIVE; PBPK; pharmacokinetics; physiological model scaling; transporters;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Comparative Assessment of In Vitro-In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs

Keywords: disposition; microsomes; clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes

Keywords: distribution; microsomes; clearance; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Extrapolating In vitro Metabolic Interactions to Isolated Perfused Liver: Predictions of Metabolic Interactions between R-Bufuralol, Bunitrolol, and Debrisoquine

Keywords: metabolism in vitro; in vitro-in vivo extrapolation; IVIVE; drug interaction; DDI; microsomes; liver model; isolated perfused liver; metabolic clearance; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2010 سفارش ترجمه