Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro-in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans

► Investigate the tissues/gender difference of in vitro CD metabolism in rodents and human. ► Demonstrate a probabilistic approach to integrate in vitro information to PBPK models. ► Compare the results of estimated metabolism parameters via probabilistic and deterministic method. ► Evaluate the impacts of uncertainty of metabolism parameters on the target tissue dosimetry.