Keywords: JNK، c-Jun N-terminal kinase; CFTR, cystic fibrosis transmembrane conductance regulator; ECM, extracellular matrix; FRET, Förster resonance energy transfer; JNK, c-Jun N-terminal kinase; PCP, planar cell polarity; ROCK, Rho-associated protein kinase; VEGF, vascular endothelial growth
مقالات ISI JNK، c-Jun N-terminal kinase (ترجمه نشده)
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Keywords: JNK، c-Jun N-terminal kinase; HF, high fat; LPS, lipopolysaccharide; IPGTT, intraperitoneal glucose tolerance test; BDNF, brain-derived neurotrophic factor; TLR, Toll-like receptor; MyD88, myeloid differentiation primary-response protein 88; JNK, c-Jun N-terminal kinase; NFκB, nuclear
Keywords: JNK، c-Jun N-terminal kinase; Andro, andrographolide; ERK, extracellular regulated kinase; HCC, Hepatocellular carcinoma; HPLC, high pressure liquid chromatography; JNK, c-Jun N-terminal kinase; KEGG, Kyoto Encyclopedia Genes $amp Genomes; MPAKs, mitogen-activated protein kinases; miR
Keywords: JNK، c-Jun N-terminal kinase; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; MAPKs, mitogen-activated protein kinases; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide dye; NSE, neuron-specific enolase; 15d-PGJ2, 15-deoxy-Δ12,14-prostagland
Keywords: JNK، c-Jun N-terminal kinase; ActB, β-actin; Akt, protein kinase B; COX2, cyclooxygenase 2; ERK, extracellular signal-regulated kinase; FAK, focal adhesion kinase; GPx, glutathione peroxidase; IκBα, NF-κB inhibitor α; JNK, c-Jun N-terminal kinase; MDA, malondialdehyde; NF-κB, nuclear
Keywords: JNK، c-Jun N-terminal kinase; APN, adiponectin; HCC, hepatocellular carcinoma; JNK, C-Jun N-terminal kinase; Trx, thioredoxin; NAC, N-acetylcysteine; AMPK, 5′-adenosine monophosphate-activated protein kinase; ROS, reactive oxygen species; ASK1, apoptosis signal-regulating kinase 1; PC
Keywords: JNK، c-Jun N-terminal kinase; AP-1, activator protein-1; DRF, dose reduction factor; ERK, extracellular signal regulated kinase; E. cava, Ecklonia cava; HO-1, heme oxygenase-1; IκBα, I kappa B kinase alpha; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MKK-4, m
Keywords: JNK، c-Jun N-terminal kinase; ECM; integrin ligands; JNK; paxillin; EMT; trabecular meshwork cell; migrationTM, trabecular meshwork; ECM, extracellular matrix; EMT, epithelial mesenchymal transition; JNK, c-Jun N-terminal kinase; α-SMA, α-smooth muscle actin; TGF-β, transforming growt
Keywords: JNK، c-Jun N-terminal kinase; NSCLC; CCRT; Vinorelbine; JNK; CeramideNSCLC, non-small cell lung cancer; CCRT, concurrent chemoradiotherapy; VNR, vinorelbine; JNK, c-Jun N-terminal kinase; CT, chemotherapy; RT, radiotherapy; NAC, N-acetyl-L-cysteine
Keywords: JNK، c-Jun N-terminal kinase; SIRT1, silent information regulator 1; OSI, oxidative stress injury; HUVECs, human umbilical vein endothelial cells; H2O2, hydrogen peroxide; ROS, reactive oxygen species; NAD+, nicotinamide adenine dinucleotide; JNK, c-Jun N-terminal kinase; p38MAPK, p38
Keywords: JNK، c-Jun N-terminal kinase; ERK, extracellular signal-regulated kinase; GGA, geranylgeranylacetone; HSP70, heat shock protein 70; JNK, c-jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MITF, microphthalmia-associated transcription factor; PARP, poly(ADP-ribose) polyme
Keywords: JNK، c-Jun N-terminal kinase; ERK, extracellular matrix-regulated kinase; HEEC, human endometrial epithelial cell; HUVEC, human umbilical vein endothelial cell; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; NADPH oxidase, nicotinamide adenine dinucleotide phosp
Keywords: JNK، c-Jun N-terminal kinase; AhR, aryl hydrocarbon receptor; ANF, α-naphthoflavone; EMT, epithelial-mesenchymal transition; ERα, estrogen receptor α; ERK1/2, extracellular signal related kinase 1 and 2; HCB, hexachlorobenzene; JNK, c-jun n-terminal kinase; TCDD, 2,3,7,8-tetrachlorodi
Go is required for the release of IL-8 and TNF-α, but not degranulation in human mast cells
Keywords: JNK، c-Jun N-terminal kinase; Akt, Protein kinase B; BAC, Benzalkonium chloride; FcεRI, High-affinity receptor for IgE; G protein, Guanine nucleotide-binding protein; GPCRs, Gprotein-coupled receptors; JNK, c-Jun N-terminal kinase; LAD2 cells, Laboratory of allergic disease 2 human ma
Costunolide, an active sesquiterpene lactone, induced apoptosis via ROS-mediated ER stress and JNK pathway in human U2OS cells
Keywords: JNK، c-Jun N-terminal kinase; DAPI, 4′,6-diamidino-2-phenylindole; OS, osteosarcoma; ROS, reactive oxygen species; ER, endoplasmic reticulum; MAPK, mitogen activated protein kinase; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; ASK1, apoptosis signal-regula
Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways
Keywords: JNK، c-Jun N-terminal kinase; ALI, acute lung injury; ARDS, acute respiratory distress syndrome; BALF, bronchoalveolar lavage fluid; DSS, dextran sulfate sodium; H&E, hematoxylin & eosin; HRP, horseradish peroxidase; IL-6, interleukin-6; JNK, c-Jun N-terminal kinase; LPS, lipopolysacc
PDZ1 inhibitor peptide protects neurons against ischemia via inhibiting GluK2-PSD-95-module-mediated Fas signaling pathway
Keywords: JNK، c-Jun N-terminal kinase; PSD-95, Postsynaptic density protein 95; MLK3, Mixed Lineage Kinase 3; JNK, c-Jun N-terminal kinase; FADD, Fas associated death domain protein; DISC, death-inducing signaling complexCerebral ischemia; GluK2; PSD-95; Fas; FasL; Peptide
Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover
Keywords: JNK، c-Jun N-terminal kinase; AIF, apoptosis-inducing factor; cFLIP, FLICE-like inhibitory protein; AMPK, AMP-activated protein kinase; DISC, death-inducing signaling complex; FITC, fluorescein isothiocyanate; JNK, c-Jun N-terminal kinase; PDAC, Pancreatic ductal adenocarcinoma; MMP,
Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-κB pathway with anti-inflammatory properties
Keywords: JNK، c-Jun N-terminal kinase; RTFs, flavonoids isolated from Radix Tetrastigmae; TLR4, Toll-like receptor 4; MD-2, myeloid differentiation factor-2; NF-κB, nuclear transcription factor-kappa B; MAPKs, mitogen-activated protein kinases; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccha
Tricin, flavonoid from Njavara reduces inflammatory responses in hPBMCs by modulating the p38MAPK and PI3K/Akt pathways and prevents inflammation associated endothelial dysfunction in HUVECs
Keywords: JNK، c-Jun N-terminal kinase; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinase; ERK 1/2, extracellular signal-regulated kinases 1/2; JNK, c-Jun N-terminal kinase; hPBMCs, human peripheral blood mononuclear cells; HUVECs, human umbilical vein endothelial cellsFlavonoid;
Dual inhibition of nitric oxide and prostaglandin E2 production by polysubstituted 2-aminopyrimidines
Keywords: JNK، c-Jun N-terminal kinase; Pyrimidines; Nitric oxide; Prostaglandin E2; Ulcerative colitisCOX, cyclooxygenase; DAI, disease activity index; DSS, dextran sulfate sodium; ERK, extracellular signal-regulated kinase; IFN-γ, interferon-γ; JNK, c-Jun N-terminal kinase; LPS, lipopolysacch
Ste20-like kinase, SLK, activates the heat shock factor 1 – Hsp70 pathway
Keywords: JNK، c-Jun N-terminal kinase; GEC, glomerular epithelial cell; GFP, green fluorescent protein; HA, hemaglutinin antigen epitope tag; HSF1, heat shock factor 1; ΔHSF1, constitutively active HSF1; Hsp, heat shock protein; JNK, c-Jun N-terminal kinase; PLK, polo-like kinaseCell death; Is
The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175WT/HD mice
Keywords: JNK، c-Jun N-terminal kinase; Bcl-XL, B-cell lymphoma-extra large; BDNF, brain-derived neurotrophic factor; DARPP-32, dopamine and cAMP-regulated phosphoprotein, MW 32 kDa; HD, Huntington’s disease; HTT, Huntingtin protein; IHC, immunohistochemistry; JNK, c-Jun N-terminal kinase; mHTT
Intestinal Dysbiosis Contributes to the Delayed Gastrointestinal Transit in High-Fat Diet Fed Mice
Keywords: JNK، c-Jun N-terminal kinase; Myenteric Neurons; Palmitate; Gut Microbiota; LPS; TLR4; Colon TransitFITC, fluorescein isothiocyanate; HEK, human embryonic kidney; HFD, high-fat diet; IM-PEN, immortal postnatal enteric neuronal; JNK, c-Jun N-terminal kinase; LCM, laser capture microdis
Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status
Keywords: JNK، c-Jun N-terminal kinase; Cx, connexin; Cx43, connexin43; TJs, tight junctions; AJs, adherens junctions; GJs, gap junctions; siRNA, small interfering RNA; Cx43+/+, Cx43 wide-type mouse; Cx43+/-, Cx43 heterozygous mouse; Cx43-/-, Cx43 knockout mouse; JNK, c-Jun N-terminal kinase; G
Transient glutathione depletion in the substantia nigra compacta is associated with neuroinflammation in rats
Keywords: JNK، c-Jun N-terminal kinase; BSO, l-buthionine sulfoximine; CS, corpus striatum; IL, interleukin; JNK, c-Jun N-terminal kinase; NO, nitric oxide; PD, Parkinson’s disease; ROS, reactive oxygen species; SNpc, substantia nigra pars compacta; TNF, tumor necrosis factor; UTR, untreated; V
The adaptor protein Cindr regulates JNK activity to maintain epithelial sheet integrity
Keywords: JNK، c-Jun N-terminal kinase; CP, actin-capping protein; AJ, adherens junction; APF, after puparium formation; A/P, anterior/posterior; Bsk, basket; β-Gal, β-Galactosidase; JNK, c-Jun N-terminal kinase; Chic, chickadee; Dcr-2, dicer-2; D/V, dorsal/ventral; dJNK, Drosophila JNK; Jra or
Extracellular melanogenesis inhibitory activity and the structure-activity relationships of ugonins from Helminthostachys zeylanica roots
Keywords: JNK، c-Jun N-terminal kinase; ERK, extracellular signal-regulated kinases; JNK, c-Jun N-terminal kinase; l-DOPA, l-3,4-dihydroxyphenylalanine; MITF, microphthalmia-associated transcription factor; MAPK, mitogen-activated protein kinaseHelminthostachys zeylanica; Tyrosinase; B16 melano
Animal Models Correlating Immune Cells for the Development of NAFLD/NASH
Keywords: JNK، c-Jun N-terminal kinase; APPs, acute-phase proteins; BAFF, B cell activating factor; Btk, Bruton's tyrosine kinase gene; DAMPs, damage-associated molecular patterns; HCC, hepatocellular carcinoma; IRFs, Interferon regulatory factors; JNK, c-Jun N-terminal kinase; MCD, methionine
Topiramate protects against glutamate excitotoxicity via activating BDNF/TrkB-dependent ERK pathway in rodent hippocampal neurons
Keywords: JNK، c-Jun N-terminal kinase; TPM, topiramate; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl -tetrazolium bromide; BDNF, brain-derived neurotrophic factor; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; CREB, cyclic A
Mitochondrial JNK activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia/reperfusion
Keywords: JNK، c-Jun N-terminal kinase; AI, apoptosis index; COX, cytochrome c oxidase; JNK, c-Jun N-terminal kinase; LDH, lactate dehydrogenase; LVSP, left ventricular systolic pressure; MABP, mean arterial blood pressure; mitoJNK, mitochondrial JNK; mTOR, mammalian target of rapamycin; TUNEL,
P38 participates in spermatogenesis and acrosome reaction prior to fertilization in Chinese mitten crab Eriocheir sinensis
Keywords: JNK، c-Jun N-terminal kinase; MAPKs, mitogen-activated protein kinases; AR, acrosome reaction; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; MAPK14, p38α; Thr-Gly-Tyr, threonine–glycine–tyrosine; AV, acrosomal vesicle; AT, acrosomal tubule; AC, apical cap;
A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression
Keywords: JNK، c-Jun N-terminal kinase; ACC, acetyl-CoA carboxylase; DM, diabetes mellitus; DPP4, dipeptidyl peptidase-4; FAS, fatty acid synthase; FFA, free fatty acids; GLP-1, glucagon-like peptide; JNK, c-Jun N-terminal kinase; LECT2, leukocyte cell-derived chemotaxin 2; LPS, lipopolysacchar
Perspective on computational and structural aspects of kinase discovery from IPK2014
Keywords: JNK، c-Jun N-terminal kinase; Abl, Abelson murine leukemia; MD, Molecular dynamics; Melk, Maternal embryonic leucine zipper kinase; Kit, v-kit Hardy–Zuckerman 4 feline sarcoma viral oncogene homolog; JNK, c-Jun N-terminal kinase; PLK, Polo like kinase; CDK, Cyclin dependent kinase; ER
Hepatitis B virus X protein increases the IL-1β-induced NF-κB activation via interaction with evolutionarily conserved signaling intermediate in Toll pathways (ECSIT)
Keywords: JNK، c-Jun N-terminal kinase; AP-1, activating protein-1; ECSIT, evolutionarily conserved signaling intermediate in Toll pathways; HB, xhepatitis B virus X protein; I, κBinhibitor of NF-κB; IRAK, interleukin-1 receptor-associated kinase; JNK, c-Jun N-terminal kinase; MAPK, mitogen-act
III-10, a newly synthesized flavonoid, induces cell apoptosis with the involvement of reactive oxygen species-mitochondria pathway in human hepatocellular carcinoma cells
Keywords: JNK، c-Jun N-terminal kinase; AIF, apoptosis-inducing factor; Cyt C, cytochrome c; ERK, extracellular regulated protein kinase; GSH, glutathione; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinases; MMP, mitochondrial membrane potential; NAC, N-acetyl-cysteineApoptos
Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats
Keywords: JNK، c-Jun N-terminal kinase; ANT, anthracycline; Cp, crossing point; DOX, doxorubicin; ELISA, enzyme linked immunosorbent assay; HO-1, heme oxygenase-1; JNK, c-Jun N-terminal kinase; MKP1, mitogen-activated protein kinase phosphatase 1; RT-qPCR, real-time quantitative PCR; SDs, solid
Inhibition of thioredoxin-1 with siRNA exacerbates apoptosis by activating the ASK1-JNK/p38 pathway in brain of a stroke model rats
Keywords: JNK، c-Jun N-terminal kinase; Trx1, thioredoxin-1; MCAO, middle cerebral artery occlusion; I/R, ischemia/reperfusion; siRNA, small interfering RNA; ASK1, apoptosis signal-regulating kinase-1; P-ASK1, phosphorylation of apoptosis signal-regulating kinase-1; JNK, c-Jun N-terminal kinase
Localization of 14-3-3δ/ξ on the neuronal cell surface
Keywords: JNK، c-Jun N-terminal kinase; Aβ, amyloid β; AD, Alzheimer's disease; 15d-PGJ2, 15-deoxy-Δ12,14- prostaglandins J2; DP2, Type 2 receptor for prostaglandin D2; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MTT, 3-(4,5-
Gamma-secretase-independent role for cadherin-11 in neurotrophin receptor p75 (p75NTR) mediated glioblastoma cell migration
Keywords: JNK، c-Jun N-terminal kinase; P75NTR, p75 neurotrophin receptor; Cdh-11, cadherin-11; MAPK, mitogen-activated protein kinase; PI-3 K, phosphatidylinositol 3-kinase; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; JNK, c-Jun N-terminal kinase; ADAM17, a disintegr
FAK signaling in human cancer as a target for therapeutics
Keywords: JNK، c-Jun N-terminal kinase; Tumorigenesis; Metastasis; Tyrosine kinase; Scaffold protein; Tyrosine kinase inhibitor; Cancer stem cellsATP, Adenosine triphosphate; CDK, cyclin-dependent kinase; JNK, c-jun N-terminal kinase; DRT, detergent-resistant membrane; EC, endothelial cell; EGF
Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons
Keywords: JNK، c-Jun N-terminal kinase; Wnt-5a, Wingless-type family member 5a; NO, nitric oxide; NMDAR, N-methyl-d-aspartate receptor; sFRP-2, soluble Frizzled related protein-2; Wnt/PCP, Wnt/planar cell polarity; JNK, c-Jun N-terminal kinase; CaMKII, Ca2+/calmodulin dependent kinase II; PKC,
The JNK1/JNK3 interactome – Contributions by the JNK3 unique N-terminus and JNK common docking site residues
Keywords: JNK، c-Jun N-terminal kinase; CD site, common docking site; JBD, JNK-binding domain; JNK, c-Jun N-terminal Kinase; MAPK, mitogen-activated protein kinasec-Jun N-terminal Kinase; Activating transcription factor 7; A kinase anchoring protein 6; Ataxin-1
Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia
Keywords: JNK، c-Jun N-terminal kinase; CCI, chronic constriction injury; DMSO, dimethyl Sulfoxide; DRG, dorsal root ganglia; IκB, inhibitor of NF-κB; IKK, inhibitor IκB; JNK, c-Jun N-terminal kinase; MAPK/ERK, mitogen-activated protein kinase/extracellular signal-regulated kinase; MEK1/2, mito
SP600125 overcomes antimitotic drug-resistance in cancer cells by increasing apoptosis with independence of P-gp inhibition
Keywords: JNK، c-Jun N-terminal kinase; Jnk, c-Jun N-terminal kinase; S.D., Standard deviation; SP, SP600125; PAC, Paclitaxcel; DOC, Docetaxcel; VIB, Vinblastine; COL, Colchicine; DOX, Doxorubicin; MDR, Multi drug-resistance; P-gp, P-glycoprotein; DMSO, Dimethylsulfoxide; FACS, Fluorescence-act
Involvement of lysosomal degradation in VEGF-C-induced down-regulation of VEGFR-3
Keywords: JNK، c-Jun N-terminal kinase; BSA, bovine serum albumin; DAPT, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester; EC, endothelial cell; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; LEC, lymphatic endothelial cell; LPE, leupeptin, pepsta
The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor
Keywords: JNK، c-Jun N-terminal kinase; PAP, prostatic acid phosphatase; HIF1α/2α, hypoxia-inducible factors 1α/2α; GSCs, glioblastoma stem cells; NSCs, neural stem cells; SCM, tumor stem cell propagating medium; MAPKs, mitogen-activated protein kinases; JNK, c-Jun N-terminal kinase; Akt/PKB, p
Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation
Keywords: JNK، c-Jun N-terminal kinase; AD, Alzheimer's disease; ANOVA, analysis of variance; Aβ, amyloid-β; DA, diacetate; DCF, 2′,7′-dichlorofluorescein; DMSO, dimethyl sulfoxide; ERK 1/2, extracellular signal-regulated kinases 1/2; H2DCF, reduced DCF; JNK, c-Jun N-terminal kinase; MAPK, mito
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling
Keywords: JNK، c-Jun N-terminal kinase; Cytochrome P450 2E1; c-Jun N-terminal kinase; Alcoholic liver disease; Oxidative stress; Mitogen-activated protein kinasesAPAP, acetaminophen; CYP2E1, cytochrome P450 2E1; ERK1/2, extracellular signal-regulated kinase 1/2; JNK, c-Jun N-terminal kinase; MA
Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity
Keywords: JNK، c-Jun N-terminal kinase; PG, prostaglandin; NO, nitric oxide; COX, cyclooxygenase; iNOS, inducible NO synthase; TLR, toll-like receptors (TLR); NF-κB, nuclear factor-κB; AP-1, activator protein-1; JNK, c-Jun N-terminal kinase; EIA, enzyme immunoassay; MTT, 3-4,5-dimethylthiazol-2