Keywords: گیرنده اپوئیدی کاپاپ; Kappa opioid receptor; Insertion-deletion; DNA methylation; Gene expression; Genotype; Depression;
مقالات ISI گیرنده اپوئیدی کاپاپ (ترجمه نشده)
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Keywords: گیرنده اپوئیدی کاپاپ; Kappa opioid receptor; Anhedonia; Social interaction; Social defeat stress; Depression;
Keywords: گیرنده اپوئیدی کاپاپ; 3âV; third ventricle; BDNF; brain-derived neurotrophic factor; BT3; BetaTubulin-III; CA1; cornu ammonis area 1; CAq; cerebral aqueduct; CNS; central nervous system; CPE; choroid plexus epithelium; CSF; cerebrospinal fluid; DAPI; 4,6-diamidino-2-phenylin
Keywords: گیرنده اپوئیدی کاپاپ; Mu opioid receptor; Delta opioid receptor; Kappa opioid receptor; Pain; Analgesia; Structure activity relationship;
Keywords: گیرنده اپوئیدی کاپاپ; Antidepressants; Depression; Kappa opioid receptor; Ketamine; Oxytocin social behavior; Sex differences;
Keywords: گیرنده اپوئیدی کاپاپ; BNST; Bed nucleus of the stria terminalis; DYN; Dynorphin; KOR; Kappa-opioid receptor; MOR; mu-opioid receptor; nor-BNI; nor-binaltorphimine; Oprk1; KOR gene; Pdyn; Prodynorphin - DYN gene; USV; Ultrasonic vocalization; SA; Self administration; Alcohol de
Keywords: گیرنده اپوئیدی کاپاپ; AUD; Alcohol use disorder; FDA; Food and Drug Administration; MOR; Mu opioid receptor; DOR; Delta opioid receptor; KOR; Kappa opioid receptor; NMDA; N-methyl-d-aspartate; GABA; Gaba amino butyric acid; DSM-IV; Diagnostic and statistical measurement IV; PA
Keywords: گیرنده اپوئیدی کاپاپ; Fatty acids; Developmental periods; Conditioned place preference; Kappa opioid receptor; D1 receptor; NMDA receptor;
Keywords: گیرنده اپوئیدی کاپاپ; Kappa opioid receptor; Aversion; Sex difference; Nucleus accumbens; Social defeat stress;
Keywords: گیرنده اپوئیدی کاپاپ; Chronic alcohol exposure; Alcohol withdrawal; Stress; Alcohol drinking; Neuropeptides; HPA; hypothalamic-pituitary-adrenocortical; CRF; corticotropin-releasing factor; DYN; dynorphin; KOR; kappa opioid receptor; CeA; central nucleus of the amygdala; BNST;
Keywords: گیرنده اپوئیدی کاپاپ; Kappa opioid receptor; Serotonin; Clearance; Serotonin transporter; Phosphorylation; Trafficking; 5-HT; 5-hydroxytryptamine (serotonin); Akt X; Akt inhibitor X (10-(4â²-(N-diethylamino)butyl)-2-chlorophenoxazine); Akt; protein kinase B/Akt; BNI; nor-bina
Keywords: گیرنده اپوئیدی کاپاپ; Nicotine sensitization; Dynorphin; Kappa opioid receptor; Orphanin FQ/nociceptin; Nociceptin receptor; Gene expression;
Keywords: گیرنده اپوئیدی کاپاپ; CREB; cAMP response element-binding protein; DOP; delta opioid receptor; EFNS; European Federation of Neurological Societies; IASP; International Association for the Study of Pain; IL; interleukin; KOP; kappa opioid receptor; MOP; mu opioid receptor; NET;
Keywords: گیرنده اپوئیدی کاپاپ; Ach; acetylcholine; ACTH; adrenocorticotrophic hormone; BDNF; brain-derived neurotrophic factor; BEND; beta-endorphin; BFNA; beta-funaltrexamine; BNST; bed nucleus of the stria terminalis; Ca(2+); calcium; CaMKII; calcium/calmodulin-dependent protein kina
Keywords: گیرنده اپوئیدی کاپاپ; Biased agonism; Opioid receptor; Kappa opioid receptor; Dynorphin; Mood disorders;
Keywords: گیرنده اپوئیدی کاپاپ; BN; Bombesin; CGRP; calcitonin gene-related peptide; DRG; dorsal root ganglion/ganglia; FITC; fluorescein isothiocyanate; GRP; gastrin-releasing peptide; GRPR; gastrin-releasing peptide receptor; 5â²-GNTI; 5â²-guanidinonaltrindole; i.c.v.; intracerebrov
Keywords: گیرنده اپوئیدی کاپاپ; Aortocaval fistula; Heart failure; Kappa opioid receptor; Prodynorphin; Localization;
Keywords: گیرنده اپوئیدی کاپاپ; Drug reward; Dynorphin; Kappa opioid receptor; Paraventricular nucleus of thalamus; BNST; bed nucleus of the striaterminalis; CeA; central amygdala; Dyn-A; dynorphin-A; GIRK; G-protein-coupled inwardly rectifying potassium; GPCRs; G-protein coupled recept
Keywords: گیرنده اپوئیدی کاپاپ; BLa; basolateral nucleus; BLC; basolateral nuclear complex; CCK+; cholecystokinin-positive; DAB; diaminobenzidine; DOR; delta opioid receptor; KOR; kappa opioid receptor; MOR; mu opioid receptor; MOR+; MOR-positive; MOR-ir; MOR-immunoreactivity; PAG; peri
Keywords: گیرنده اپوئیدی کاپاپ; Fear extinction; Exposure therapy; Augmented relearning; Reconsolidation; Drug development; Cognitive enhancer; 5-HT; 5-hydroxytryptamine = serotonin; AC; adenylate cyclase; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMY; amygdala; BA;
Keywords: گیرنده اپوئیدی کاپاپ; Lateral olivocochlear efferent; Auditory nerve; Cochlear whole nerve action potential; Dynorphin; Kappa opioid receptor;
Keywords: گیرنده اپوئیدی کاپاپ; HPA axis; POMC; Dynorphin; Mu opioid receptor; Kappa opioid receptor; Vasopressin; V1b receptor;
Keywords: گیرنده اپوئیدی کاپاپ; Kappa opioid receptor; Aversion; Sex Difference; Social behavior
Keywords: گیرنده اپوئیدی کاپاپ; Ach; acetylcholine; AchE; acetylcholine esterease; ACTH; adrenocorticotrophic hormone; ADHD; attention deficit/hyperactivity disorder; AIDS; autoimmune deficiency syndrome; AMSH; alpha-melanocyte-stimulating hormone; BAM; bovine adrenal medulla peptide; B
Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy
Keywords: گیرنده اپوئیدی کاپاپ; δ-OR; delta-opioid receptor; DPN; diabetic polyneuropathy; ED50; half-effective drug dose; Emax; maximally effective drug dose; HPT; hot plate threshold; κ-OR; kappa opioid receptor; M6S; morphine-6-O-sulfate; MPE; maximum possible effect; μ-OR; mu-opi
Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats
Keywords: گیرنده اپوئیدی کاپاپ; Juvenile; Adolescent; Adult; Social behavior; Kappa opioid receptor; Restraint stress; Development;
Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration?
Keywords: گیرنده اپوئیدی کاپاپ; Oxidative stress (OS); Delta opioid receptor (DOR); Poly (ADP-ribose)-polymerase1 (PARP1); Neuroprotection; Attenuation; OS; Oxidative stress; DOR; Delta opioid receptor; PARP; Poly (ADP-ribose)-polymerase; AD; Alzheimer's disease; PD; Parkinson's disease
Prodynorphin and kappa opioid receptor mRNA expression in the brain relates to social status and behavior in male European starlings
Keywords: گیرنده اپوئیدی کاپاپ; mPOA; medial preoptic nucleus; OPRK1; kappa opioid receptor; PDYN; prodynorphin; qPCR; quantitative real-time polymerase chain reaction; VTA; ventral tegmental area; Kappa receptor; Dynorphin; Social behavior; Dominance; Songbird; Territoriality;
N-[18F]-FluoropropylJDTic for κ-opioid receptor PET imaging: Radiosynthesis, pre-clinical evaluation, and metabolic investigation in comparison with parent JDTic
Keywords: گیرنده اپوئیدی کاپاپ; kappa Opioid receptor; PET imaging; JDTic; Fluorine-18; Metabolism; N-fluoroalkylation;
Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
Keywords: گیرنده اپوئیدی کاپاپ; ACEA; arachidonyl-2â²-chloroethylamide; AEA; N-arachidonoylethanolamide, anandamide; APN; aminopeptidase N; BNI; nor-binaltorphimine; CCI; chronic constrictive injury; CYP; cyprodime; DENKI; dual enkephalinase inhibitor; DOR; delta opioid receptor; ENK;
Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor
Keywords: گیرنده اپوئیدی کاپاپ; Kappa opioid receptor; Biased signaling; p38 MAPK; Dysphoria; ERK1/2; extracellular signal-regulated kinase; GRK3; G protein-coupled receptor kinase 3; hKOR; human kappa opioid receptor; MAPK; mitogen activated protein kinase; norBNI; norbinaltorphimine;
ReviewControl of arousal through neuropeptide afferents of the locus coeruleus
Keywords: گیرنده اپوئیدی کاپاپ; LC; locus coeruleus; CRF; corticotropin releasing factor; ORX; orexin; MCH; melanin-concentrating hormone; SS; somatostatin; NE; norepinephrine; KOR; kappa opioid receptor; MOR; mu opioid receptor; PVN; paraventricular nucleus of the hypothalamus; CNA; ce
Does environmental exposure to the greenhouse gas, N2O, contribute to etiological factors in neurodevelopmental disorders? A mini-review of the evidence
Keywords: گیرنده اپوئیدی کاپاپ; Autism spectrum disorders; ADHD; Air pollution; Nitrous oxide; Kappa opioid receptor; Dynorphin; Nitrogen fertilizers; Glyphosate; NMDA receptor; Dopamine; Methionine synthase; Alpha 7 nicotinic acetylcholine receptor; Oxytocin; Estrogen; Nitric oxide; Op
Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel β-arrestin-2-biased pathway
Keywords: گیرنده اپوئیدی کاپاپ; GPCR; Kappa opioid receptor; Neurotensin receptor 1; Heterodimerization;
Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests
Keywords: گیرنده اپوئیدی کاپاپ; 5â²-GNTI; 5â²-guanidinonaltrindole; ANOVA; analysis of variance; AZ-ECPC; ethyl 4-(3-carbamoylbenzyl)-1-(cyclohexylmethyl)piperidine-4-carboxylate; AZ-MTAB; 3-((1R,3r,5S)-8-((5-methylthiophen-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide; DOPR
Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice
Keywords: گیرنده اپوئیدی کاپاپ; LY2456302; Kappa opioid receptor; Nicotine withdrawal; Kappa opioid receptor antagonist; Nicotine dependence;
The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism
Keywords: گیرنده اپوئیدی کاپاپ; GPCR; G protein-coupled receptor; OX1R; orexin 1 receptor; KOR; kappa opioid receptor; JNK; c-Jun N-terminal kinase; cAMP; cyclic adenosine monophosphate; VTA; ventral tegmental area; CHO; Chinese hamster ovary; FLIPR; fluorescence in situ plate reader; P
Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies
Keywords: گیرنده اپوئیدی کاپاپ; Kappa opioid receptor; JDTic; (3R,4R)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine; Selectivity; Docking
Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif
Keywords: گیرنده اپوئیدی کاپاپ; Kappa opioid receptor; Antagonist; Molecular constraint; Potency enhancement; Tetrahydroisoquinoline
Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors
Keywords: گیرنده اپوئیدی کاپاپ; 12epiSalA; 12-epi-Salvinorin A; 7TMR; seven-transmembrane domain receptor; dynorphin A; (1â17) (HâTyrâGlyâGlyâPheâLeuâArgâArgâIleâArgâProâLysâLeuâLysâTrpâAspâAsnâGlnâOH); EKC; ethylketocyclazocine; EOM-SalB; ethoxymet
Prenatal ethanol exposure alters ethanol-induced Fos immunoreactivity and dopaminergic activity in the mesocorticolimbic pathway of the adolescent brain
Keywords: گیرنده اپوئیدی کاپاپ; AcbC; nucleus accumbens core; AcbSh; nucleus accumbens shell; ANOVA; analysis of variance; GD; gestational day; IL; infralimbic prefrontal cortex; ir; immunoreactivity; KOR; kappa opioid receptor; NHS; normal horse serum; NM; non-manipulated during gestat
Noribogaine is a G-protein biased κ-opioid receptor agonist
Keywords: گیرنده اپوئیدی کاپاپ; Noribogaine; Mu opioid receptor; Kappa opioid receptor; Biased agonist; Functional selectivity; Addiction; Narcotic; Analgesia; G-protein pathway; Beta-arrestin pathway; Computational simulation; Ibogaine; 18-MC; GPCR; G protein-coupled receptor; OPRM; μ
Endogenous opioids and feeding behavior: A decade of further progress (2004–2014). A Festschrift to Dr. Abba Kastin
Keywords: گیرنده اپوئیدی کاپاپ; Food intake; Mu opioid receptor; Delta opioid receptor; Kappa opioid receptor; ORL-1 opioid receptor
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus
Keywords: گیرنده اپوئیدی کاپاپ; Pruritus; Kappa opioid receptor; Biased ligand; Mouse models of itch; U50,488H; KOR antagonist; βarr2-KO; βarrestin2 knockout; CP; chloroquine phosphate; CPA; conditioned place aversion; DMSO; dimethyl sulfoxide; 5â²-GNTI; 5â²-guanidinonaltrindole; GP
Heterodimerization of human orexin receptor 1 and kappa opioid receptor promotes protein kinase A/cAMP-response element binding protein signaling via a Gαs-mediated mechanism
Keywords: گیرنده اپوئیدی کاپاپ; GPCR; G-protein-coupled receptor; OX1R; orexin (hypocretin) receptor 1; KOR; kappa opioid receptor; BRET; bioluminescence resonance energy transfer; FRET; fluorescence resonance energy transfer; CREB; cAMP-response element binding protein; PKA; protein ki
Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting
Keywords: گیرنده اپوئیدی کاپاپ; Dynorphin; Kappa opioid receptor; [35S]GTPγS binding; Mouse striatum; Selectivity; Drug discovery; KOR antagonist; CTOP; D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2; DAMGO; [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin; Dyn; dynorphin; DOR; delta opioid receptor; [
Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice
Keywords: گیرنده اپوئیدی کاپاپ; Itch; Scratching; Kappa opioid receptor; Kappa opioid receptor antagonist; Zyklophin5′-GNTI, 5′-guanidinonaltrindole; norBNI, norbinaltorphimine; KOPR, kappa opioid receptor
Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord
Keywords: گیرنده اپوئیدی کاپاپ; Dynorphin A; Opioid; Non-opioid; Bradykinin receptor; Neuropathy; Spinal cord; WDR; Wide dynamic range; DRG; Dorsal root ganglia; B2 receptor; Bradykinin 2 receptor; SNL; Spinal nerve ligation; CFA; Complete freund's adjuvant; KOR; Kappa opioid receptor;
The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors
Keywords: گیرنده اپوئیدی کاپاپ; Alcohol; amygdala; dependence; dynorphin; kappa opioid receptor; self-administration; withdrawal
Poststress Block of Kappa Opioid Receptors Rescues Long-Term Potentiation of Inhibitory Synapses and Prevents Reinstatement of Cocaine Seeking
Keywords: گیرنده اپوئیدی کاپاپ; Glucocorticoid receptor; kappa opioid receptor; reinstatement; stress; synaptic plasticity; ventral tegmental area