Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; ARE, antioxidant response element; BBB, blood–brain barrier; FCCP, carbonilcyanide p-triflouromethoxyphenylhydrazone; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor E2-related factor 2; OCR, oxygen consumption rate; pMCAO, permanent midd
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Senkyunolide I protects rat brain against focal cerebral ischemia–reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; I/R, ischemia–reperfusion; tMCAO, transient middle cerebral artery occlusion; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor erythroid 2-related factor 2; ARE, antioxidant response element; MDA, malondialdehyde; SOD, superoxide dismutase
Nrf2-regulated antioxidant response is activated by protein kinase C in postconditioned rat hearts
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; PostC, postconditioning; PKC, protein kinase C; Nrf2, nuclear factor E2-related factor 2; ROS, reactive oxygen species; Keap1, Kelch-like ECH-associated protein 1; γ-GCS, γ-glutamylcysteine synthetase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; Q, c
Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; LLNA, local lymph node assay; Nrf2, nuclear factor-erythroid 2-related factor 2; Keap1, Kelch-like ECH-associated protein 1; ARE, antioxidant response element; FCS, fetal calf serum; qRT-PCR, quantitative real time polymerase chain reaction; DMSO, dimethy
The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; ABC, ATP-binding cassette; Mrp1, multidrug resistance protein 1; Nrf2, nuclear factor E2-related factor-2; Keap1, kelch-like ECH-associated protein 1; ARE, antioxidant response element; ROS, reactive oxygen species; GSH, reduced glutathione; GSSG, oxidize
Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; CREB, cAMP-responsive element-binding protein; HIF-1, hypoxia-inducible factor; KEAP1, Kelch-like ECH-associated protein 1; L-NAME, L-NG-nitroarginine methyl ester; MnTBap, manganese [III] tetrakis (4-benzoic acid) porphyrin; NO, nitric oxide; NFκB, nucle
Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; AMPK, AMP-activated protein kinase; ARE, antioxidant response element; ERK, extracellular signal-regulated kinase; HO-1, heme oxygenase-1; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear erythroid factor 2 (NE-F2)-related factor 2Metformin; Nrf2
Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; ARE, antioxidant response element; ARPE-19, human adult pigment epithelial cells; GSH, glutathione; H2O2, hydrogen peroxide; HO-1, heme oxygenase-1; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor erythroid 2-related factor 2; NQO1, NAD(P
Induction of activation of the antioxidant response element and stabilization of Nrf2 by 3-(3-pyridylmethylidene)-2-indolinone (PMID) confers protection against oxidative stress-induced cell death
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Keap1, kelch-like ECH-associated protein 1; Nrf2, nuclear factor (erythroid-derived 2)-like 2; Cul3, Cullin-3; ARE, antioxidant response element; GSH, glutathione; SOD, superoxide dismutase; HO-1, heme oxygenase 1; NQO1, NAD(P)H:quinone oxidoreductase 1;
Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Keap1, Kelch-like ECH-associated protein 1; L-DOPA, 3,4-dihydroxy-l-phenylalanine; NQO1, NAD(P)H:quinone oxidoreductase 1; Nrf2, NF-E2 p45-related factor 2; 2-OHE2, 2-hydroxyestradiol; 4-OHE2, 4-hydroxyestradiol; tBHQ, 2-tert-butyl-1,4-hydroquinone; tBQ,
The Keap1–Nrf2 system as an in vivo sensor for electrophiles
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Nrf2, NF-E2 related factor 2; NF-E2, nuclear factor erythroid 2; CNC, Cap’ n’ collar; Keap1, Kelch-like ECH-associated protein 1; NQO1, NAD(P)H:quinone oxidoreductase 1; UGT, UDP glucuronosyltransferase; GST, glutathione S-transferase; ARE, antioxidant re
Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; BHT, butylhydroxytoluene; EpRE, electrophile responsive element; GSH, glutathione; Keap1, kelch-like ECH-associated protein 1; MtMb, metmyoglobin; Nrf2, nuclear factor erythroid 2p45-related factor 2; NQO1, NAD(P)H:quinine oxidoreductase 1; ROS, reactive
Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; n-3 PUFA, n-3 polyunsaturated fatty acid; 4-HHE, 4-hydroxy hexenal; HO-1, heme oxygenase-1; Nrf2, nuclear factor erythroid 2-related factor 2; 4-HNE, 4-hydroxy nonenal; Keap1, Kelch-like ECH-associated protein 1; NQO1, NAD(P)H quinone oxidoreductase 1; AR
A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; ARE, antioxidant response element; HO-1, heme oxygenase-1; Nrf2, nuclear factor E2-related factor 2; Keap1, kelch-like ECH-associated protein 1; ROS, reactive oxygen speciesKavalactone; Oxidative stress; Nrf2; Antioxidant response element; Neuroprotection
Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; AO, Active Old; SO, Sedentary Old; Nrf2, nuclear factor-erythroid 2 p45-related factor 2; Keap1, kelch-like ECH-associated protein 1; ARE, Antioxidant Response Element; 8-OHdG, 8-hydroxy 2-deoxyguanosine; PC, protein carbonyls; γ-GCLC, γ-glutamylcysteine
Identification of organoselenium compounds that possess chemopreventive properties in human prostate cancer LNCaP cells
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; YNBSAUPVFBTDBB-KQTARZCWSA-N; RYRRQKNLYBSYQI-VQQFHTKMSA-NARE, antioxidant response element; HO-1, heme oxygenase-1; Nrf2, nuclear factor E2-related factor 2; Keap1, kelch-like ECH-associated protein 1; ROS, reactive oxygen speciesOrganoselenium compound; N
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; CD36, cluster of differentiation 36; Fas, fatty acid synthase; Fgf21, fibroblast growth factor 21; Gclc, glutamate cysteine ligase catalytic subunit; GST, glutathione S-transferase; Keap1, Kelch-like ECH-associated protein 1; K1-kd, Keap1-knockdown; MCD,
Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid β formation in NT2N neurons
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Alzheimer's disease; Amyloid beta; Nrf2; NT2N neurons; tBHQAD, Alzheimer's disease; AREs, Antioxidant response elements; Nrf2, Nuclear factor-erythroid 2 related factor 2; Keap1, Kelch-like ECH-associated protein 1; tBHQ, tert-Butylhydroquinone; γ-GCS, γ-
Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; KEAP1, Kelch-like ECH-associated protein 1; IKK, Inhibitor of κB kinase; NF-κB, Nucelar factor-κB; TNF, Tumor necrosis factor; HSP, Heat shock protein; Nrf2, NF-E2-related factor 2KEAP1; IKKβ; NF-κB signaling; Autophagy; TNFα
Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; LLNA, local lymph node assay; Nrf2, nuclear factor-erythroid 2-related factor 2; Keap1, Kelch-like ECH-associated protein 1; ARE, antioxidant response element; SOP, standard operating procedure; ITS, integrated testing strategy; ECVAM, European Centre for
Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor-E2-related factor 2; ARE, antioxidant response element; AOE, antioxidant enzyme; DME, drug-metabolizing enzyme; HMW, high molecular weightFalcarindiol; Alkylation; Keap1; Cysteine; Electroph
Targeting NRF2 signaling for cancer chemoprevention
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; NRF2, NF-E2-related factor 2; KEAP1, Kelch-like ECH-associated protein 1; GSTs, Glutathione S-transferases; NQO1, NAD(P)H quinine oxidoreductases; UGTs, UDP-glucuronosyl transferases; ROS, reactive oxygen species; DMBA, 7, 12-dimethylbenz[a]anthracene; TP
Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Prdx, peroxiredoxin; ARE, antioxidant-responsive element; t-BHQ, tert-butylhydroquinone; Nrf2, NF-E2-related factor 2; Nrf3, NF-E2-related factor 3; Keap1, Kelch-like ECH-associated protein 1; siRNA, short interfering RNA; ChIP, chromatin immunoprecipitat
Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Cd, cadmium; DCFH-DA, 2,7-dichloro-dihydrofluorescein diacetate; Keap1, Kelch-like ECH-associated protein 1; ARE, antioxidant response element; FACS, fluorescence activated cell sorting; FITC, fluorescein isothiocyanate; GCLC, glutamate-cysteine ligase ca
Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; iNOS, inducible form of nitric oxide synthase; COX-2, cyclooxygenase-2; CO-RM, CO-releasing molecule; CM-H2DCFDA, 5-(and -6)-chlroromethyl-2′,7′-dichlorodihydrofluorescein diacetate; Nrf2, NF-E2-related factor-2; Keap1, Kelch-like ECH-associated protein 1
Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Prx, peroxiredoxin; NF-кB, nuclear factor-kappa B; Keap1, kelch-like ECH-associated protein 1; TrxR, thioredoxin reductase; GR, glutathione reductase; GST, glutathione S-transferase; GSH, glutathione; GSSG, oxidized glutathione; PEITC, phenethyl isothiocy
Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; ROS, reactive oxygen species; HO-1, heme oxygenase 1; NQO1, NAD(P)H quinone oxidoreductase 1; GR, glutathione reductase; GPx, glutathione peroxidase; Nrf2, NF-E2-related factor-2; Keap1, Kelch-like ECH-associated protein 1; MTT, 3-(4,5-dimethylthiazol-2-y
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; GSH, reduced glutathione; NF-E2, nuclear factor-erythroid 2; ARE, antioxidant response element; Keap1, Kelch-like ECH-associated protein 1; DEM, diethylmaleate; TBS, Tris-buffered saline; HO-1, haem oxygenase-1; GCLC, glutamate cysteine ligase catalytic s
Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; Chemoprotection; Apoptosis; Phase 2 response; NQO1; Glutathione; Bis(benzylidene)acetoneCD, concentration required to double the specific activity of NQO1 in murine hepatoma Hepa1c1c7 cells; Keap1, Kelch-like ECH-associated protein 1; NQO1, NAD(P)H-quinon
Differential induction of electrophile-responsive element-regulated genes by n − 3 and n − 6 polyunsaturated fatty acids
Keywords: Keap1، پروتئین مرتبط با ECH مانند Kelch 1; AA, arachidonic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; EpRE, electrophile-responsive element; GST(P1), glutathione S-transferase (Pi 1); Keap1, Kelch-like ECH-associated protein 1; MT1, metallothionein 1; NQO1, NAD(P)H:quinone oxido-