کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051223 | 1074195 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential induction of electrophile-responsive element-regulated genes by n − 3 and n − 6 polyunsaturated fatty acids
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential induction of electrophile-responsive element-regulated genes by n − 3 and n − 6 polyunsaturated fatty acids Differential induction of electrophile-responsive element-regulated genes by n − 3 and n − 6 polyunsaturated fatty acids](/preview/png/2051223.png)
چکیده انگلیسی
In this study the n − 3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid and docosahexaenoic acid appear to be effective inducers of electrophile-responsive element (EpRE) regulated genes, whereas the n − 6 PUFA arachidonic acid is not. These n − 3 PUFAs need to be oxidized to induce EpRE-regulated gene expression, as the antioxidant vitamin E can partially inhibit the PUFA induced dose-dependent effect. Results were obtained using a reporter gene assay, real-time RT-PCR and enzyme activity assays. The induction of EpRE-regulated phase II genes by n − 3 PUFAs may be a major pathway by which n − 3 PUFAs, in contrast to n − 6 PUFAs, are chemopreventive and anticarcinogenic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 19, 21 August 2006, Pages 4587–4590
Journal: FEBS Letters - Volume 580, Issue 19, 21 August 2006, Pages 4587–4590
نویسندگان
Vincent A. van Beelen, Jac M.M.J.G. Aarts, Astrid Reus, Hans Mooibroek, Lolke Sijtsma, Dirk Bosch, Ivonne M.C.M. Rietjens, Gerrit M. Alink,