Keywords: کیناز درج دامنه; AS; activation segment; CS or C-spine; catalytic spine; CL; catalytic loop; CTT; carboxyterminal tail; D1; immunoglobulin-like domain-1; EGFR; epidermal growth factor receptor; GIST; gastrointestinal stromal tumors; GK; gatekeeper; GRL; Gly-rich loop; KD;