کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2031658 1071468 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
KIDs rule: regulatory phosphorylation of RTKs
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
KIDs rule: regulatory phosphorylation of RTKs
چکیده انگلیسی

Receptor tyrosine kinases (RTKs) are mediators of multiple cell signaling networks linked to cell growth and differentiation. In general, they exhibit similar overall structure with a ligand-binding extracellular domain and a conserved intracellular tyrosine kinase domain. In many RTKs, the kinase domain is interrupted by a sequence known as the kinase insert domain (KID). In addition to phosphorylation sites within the kinase domain, regulatory phosphorylation also occurs within the KID of several RTKs important in human health and disease. Phosphorylation of specific Tyr or Ser residues within the KID of some RTKs triggers distinct cellular signaling outcomes. Here, we review the functionality of KIDs throughout all RTK families, and provide justification for further study of this often-overlooked domain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 38, Issue 2, February 2013, Pages 75–84
نویسندگان
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