Keywords: گیرنده تیروزین کیناز; AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; ADAM; a disintegrin and metalloproteinase enzymes; ALDH; aldehyde dehydrogenase; ABC; ATP - binding cassette; BWS; Beckwith-Wiedemann syndrome; BMP; bone morphogenetic proteins; CSC; cancer s
مقالات ISI گیرنده تیروزین کیناز (ترجمه نشده)
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Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells
Keywords: گیرنده تیروزین کیناز; Insulin receptor; Insulin-like growth factor 1 receptor; Receptor tyrosine kinases; Streptavidin-binding peptide; Membrane proteins; Detergents;
Keywords: گیرنده تیروزین کیناز; Aptamer; Apoptosis; Targeted therapy; Intrinsic apoptosis pathway; Extrinsic apoptosis pathway; Intramer; Akt; PKB (protein kinase B); Bcl; B-cell lymphoma family protein; BH; Bcl-2 homology domain; Bmi-1; B lymphoma Mo-MLV insertion region 1; CD; cluster
Keywords: گیرنده تیروزین کیناز; AngII; angiotensin II; CKD; chronic kidney disease; EGF; epidermal growth factor; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; FRS2α; FGF receptor substrate 2α; HPG; heparan sulfate proteoglycans; IGF-1; insulin-like growth fa
Keywords: گیرنده تیروزین کیناز; CAPRI; Ca2+-promoted RAS inactivator; CRMP-2; collapsin response mediator protein-2; CSRD; cysteine/serine-rich domain; CTD; C-terminal domain; ERK; extracellular signal-regulated kinase; FTI; farnesyltransferase inhibitor; FAK1; focal adhesion kinase 1;
Keywords: گیرنده تیروزین کیناز; CBL; casitas B-lineage lymphoma; CtxR; cetuximab-resistant; CtxS; cetuximab-sensitive; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMT; epithelial to mesenchymal transition; EPR; epiregulin; FDA; food and
Keywords: گیرنده تیروزین کیناز; BM; bone marrow; CCL2; chemokine (C-C motif) ligand 2; COX2; cyclooxygenase-2; CXCR4; C-X-C chemokine receptor type 4; DC; dendritic cells; ECM; extracellular matrix; FKBP51; FK506 binding protein 51; G-MDSCs; granulocytic MDSCs; GPCRs; G protein coupled
Keywords: گیرنده تیروزین کیناز; α-TOS; α-tocopheryl succinate; BAP1; BRCA1 associated protein-1; BRCA1; breast cancer susceptibility gene 1; CDK4; cyclin-dependent kinase 4; CEA; carcinoembryonic antigen; CSC(s); cancer stem(-like) cell(s); CTGF; connective tissue growth factor (CCN2)
Keywords: گیرنده تیروزین کیناز; OS; overall survival; MAPK; mitogen-activated protein kinase; RTKs; receptor tyrosine kinases; PI3K; phosphatidylinositide 3-kinases; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; FTIs; farnesyltransferase inhibitors; mTOR;
Keywords: گیرنده تیروزین کیناز; Medulloblastoma; Receptor Tyrosine Kinases; DNA methyltransferases; Histone deacetylases;
Keywords: گیرنده تیروزین کیناز; AC; adenylyl cyclases; AD; Alzheimer's disease; AJ; adherent junctions; AMPAR; alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor; APC; antigen presenting cell; APP; amyloid precursor protein; Aβ; amyloid beta peptide; CAM; cellular adhesion
Keywords: گیرنده تیروزین کیناز; AJ; adherens junction; APC; adenomatous polyposis coli; ARD; armadillo repeat domain; ARVC; arrhythmogenic right ventricular cardiomyopathy; Bsk; Basket; CaM; calmodulin; Cav-1; caveolin-1; CCM; cerebral cavernous malformations; Ccm3; cerebral cavernous m
Keywords: گیرنده تیروزین کیناز; TERT; telomerase reverse transcriptase; RNP; ribonucleoprotein; TR; telomerase RNA; CSCs; cancer stem cells; TEN; telomerase essential N-terminal; TRB; TERT RNA-binding; RT; reverse transcriptase; CTE; C-terminal extension; DAT; dissociates activities of
Keywords: گیرنده تیروزین کیناز; 0EGF; epidermal growth factor; MMP; matrix metalloproteinase; RTKs; receptor tyrosine kinases; PDGF; platelet-derived growth factor; FGF; fibroblast growth factor; VEGF; vascular endothelial growth factor; NGF; nerve growth factor; Neu1; mammalian neurami
Atomistic mechanism of the constitutive activation of PDGFRA via its transmembrane domain
Keywords: گیرنده تیروزین کیناز; Receptor tyrosine kinases; Oncogenic mutations; Dimerization of transmembrane domains; Signal transduction; Molecular dynamics; NMR;
Molecularly targeted anti-cancer drugs inhibit the invasion and metastasis of hepatocellular carcinoma by regulating the expression of MMP and TIMP gene families
Keywords: گیرنده تیروزین کیناز; Hepatocellular carcinoma; Sorafenib; Regorafenib; Levnatinib; Invasion; Metastasis; Hepatocellular carcinoma; HCC; Matrix metalloproteinases; MMPs; Tissue inhibitors of MMPs; TIMPs; Extracellular matrix; ECM; Receptor tyrosine kinases; RTKs; Vascular endo
Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis
Keywords: گیرنده تیروزین کیناز; GN; glomerulonephritis; Gas6; growth-arrest-specific protein 6; BUN; blood urine nitrogen; SLE; systemic lupus erythematosus; TAM; (Tyro-3, Axl, and Mer) family; RTKs; receptor tyrosine kinases; B6; C57BL/6J; MTA; mithramycin A; H&E; hematoxylin and eosin
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential
Keywords: گیرنده تیروزین کیناز; RTKs; Receptor tyrosine kinases; VEGF; vascular endothelial growth factor; VEGFR-2; vascular endothelial growth factor receptor-2; PDGFR-β; platelet-derived growth factor receptor-β; EGFR; epidermal growth factor receptor; ATP; adenosine triphosphate; N
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: گیرنده تیروزین کیناز; Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
Survivin-targeting miR-542-3p overcomes HER3 signaling-induced chemoresistance and enhances the antitumor activity of paclitaxel against HER2-overexpressing breast cancer
Keywords: گیرنده تیروزین کیناز; HER3; Survivin; miRNA; Paclitaxel resistance; Breast cancer; RTKs; Receptor tyrosine kinases; PI-3K; Phosphoinositide 3-kinase; CHX; Cycloheximide; ELISA; Enzyme-linked immunosorbent assay; IHC; Immunohistochemistry; i.p.; Intraperitoneal;
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia
Keywords: گیرنده تیروزین کیناز; PDGFR kinase; Type II inhibitor; Kinase inhibitor; CEL; PDGFR; platelet-derived growth factor receptor; RTK; Receptor Tyrosine Kinases; ABL kinase; Abelson kinase; KIT kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; RTK; receptor ty
Dissecting the signaling features of the multi-protein complex GPCR/β-arrestin/ERK1/2
Keywords: گیرنده تیروزین کیناز; GPCRs; G protein-coupled receptors; TM; transmembrane; ECLs; extracellular loops; ICLs; intracellular loops; GRKs; G protein-coupled receptor kinases; MAPKs; mitogen activated protein kinases; ERK1/2; extracellular signal-regulated kinases 1 and 2; JNK; c
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: گیرنده تیروزین کیناز; CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
Identification of a unique loss-of-function mutation in IGF1R and a crosstalk between IGF1R and Wnt/β-catenin signaling pathways
Keywords: گیرنده تیروزین کیناز; PI3K/Akt; Wnt/β-catenin signaling; IGF1R; Receptor Tyrosine Kinases;
The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
Keywords: گیرنده تیروزین کیناز; ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: گیرنده تیروزین کیناز; Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents
Keywords: گیرنده تیروزین کیناز; MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A
Cardiac repair by epicardial EMT: Current targets and a potential role for the primary cilium
Keywords: گیرنده تیروزین کیناز; BBS8; Bardet-Biedl syndrome 8; bFGF; basic fibroblast growth factor; BMP; bone morphogenetic protein; BMSCs; bone marrow-derived hematopoietic stem cells; ECM; extracellular matrix; EGF; epidermal growth factor; EMT; epithelial-to-mesenchymal transition;
Gas6-Axl signaling in presence of Sunitinib is enhanced, diversified and sustained in renal tumor cells, resulting in tumor-progressive advantages
Keywords: گیرنده تیروزین کیناز; Renal cancer; Tumor promotion; Tumor progression; Receptor tyrosine kinases; Drug resistance; Novel mechanism;
Original ArticleEverolimus selectively targets vemurafenib resistant BRAFV600E melanoma cells adapted to low pH
Keywords: گیرنده تیروزین کیناز; Acidosis; Tumor microenvironment; BRAFV600E melanoma cells; Vemurafenib; Trametinib; Everolimus; MAPK; mitogen-activated protein kinase; RTK; receptor tyrosine kinases; ERK; extracellular signal-regulated kinases; PI3K; phosphatidylinositol 3-kinase; AKT;
Insulin promotes cell migration by regulating PSA-NCAM
Keywords: گیرنده تیروزین کیناز; PSA; polysialic acid; NCAM; neural cell adhesion molecule; ECM; membrane-like extracellular matrix; INS; insulin; WT; wortmannin; PF; PF-562271; p-Akt; phosphorylated Akt; p-FAK; phosphorylated focal adhesion kinase; RTKs; receptor tyrosine kinases; IR-β
Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells
Keywords: گیرنده تیروزین کیناز; BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetrakis(acetoxymethyl ester); CRAC; Ca2Â +-release activated Ca2Â + channel; [Ca2Â +]i; cytosolic Ca2Â + concentration; DAG; diacylglycerol; EC; endothelial cell; eNOS; endothelial ni
Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents
Keywords: گیرنده تیروزین کیناز; MDR; BCR-ABL inhibitors; EGFR inhibitors; VEGFR inhibitors; Drug combinations; ABC; ATP binding cassette; ADME-tox; absorption, distribution, metabolism, excretion, toxicity; AKT; v-akt murine thymoma viral oncogene homolog; ALL; acute lymphoblastic leuke
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents
Keywords: گیرنده تیروزین کیناز; Multiple receptor tyrosine kinase inhibitors; Antiangiogenic agents; Pyrimido[4,5-b]indole synthesis; Thymidylate synthase inhibitors; Combination chemotherapeutic potential in single agents; RTK; receptor tyrosine kinases; VEGF; vascular endothelial grow
Functional convergence of Akt protein with VEGFR-1 in human endothelial progenitor cells exposed to sera from patient with type 2 diabetes mellitus
Keywords: گیرنده تیروزین کیناز; Human endothelial progenitor cells; Diabetes mellitus; Receptor tyrosine kinases; mTOR and Hedgehog signaling pathways;
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: گیرنده تیروزین کیناز; α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway
Keywords: گیرنده تیروزین کیناز; Dynamin; AP-1; c-Jun; Receptor tyrosine kinases;
Effect of the achondroplasia mutation on FGFR3 dimerization and FGFR3 structural response to fgf1 and fgf2: A quantitative FRET study in osmotically derived plasma membrane vesicles
Keywords: گیرنده تیروزین کیناز; Receptor tyrosine kinases; Fibroblast growth factor receptor 3; Dimerization; Achondroplasia; skeletal disorders; Dimer stability;
Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system
Keywords: گیرنده تیروزین کیناز; G-protein-coupled receptors; Receptor tyrosine kinases; Fibroblast growth factor receptor 1; Serotonin receptors; Heteroreceptor complex; Dimerization;
Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions
Keywords: گیرنده تیروزین کیناز; MET; hepatocyte growth factor receptor; PTPRZ1; receptor-type tyrosine-protein phosphatase zeta; ZM; PTPRZ1-MET fusion; HGF; hepatocyte growth factor; NGS; next generation sequencing; RTKs; receptor tyrosine kinases; GBM; glioblastoma multiform; FPKM; f
Role of lipid microdomains in TLR-mediated signalling
Keywords: گیرنده تیروزین کیناز; ABCA1/G1; ATP-binding cassette, sub-family A/G, member 1; AP-1; activator protein 1; CARC; inverted “CRAC” domain; CD 14/36/55; cluster of differentiation 14/36/55; CRAC; cholesterol recognition amino-acid consensus sequence; CXCR4; C-X-C chemokine re
Functional conservation and divergence of duplicated fibroblast growth factor receptor 1 (fgfr1) genes in blunt snout bream (Megalobrama amblycephala)
Keywords: گیرنده تیروزین کیناز; Fgfr1/fgfr; fibroblast growth factor receptor; Fgf; fibroblast growth factor; MHB; mid-hindbrain boundary; RTKs; receptor tyrosine kinases; HSPG; heparan sulfate proteoglycan; PKC; protein kinase C; PI3K; phosphoinositide 3-kinase; ERKs; extracellular sig
ShcC proteins: Brain aging and beyond
Keywords: گیرنده تیروزین کیناز; ShcC adaptor proteins; Signaling; Aging; Brain ischemia; Brain tumors; Immunity; Aβ; beta-amyloid; AD; Alzheimer's disease; Akt; protein kinase B (PKB); ALK; anaplastic lymphoma kinase (receptor tyrosine kinase); APP; alpha-amyloid precursor protein; ARD
Photoactivation of TAZ via Akt/GSK3β signaling pathway promotes osteogenic differentiation
Keywords: گیرنده تیروزین کیناز; LPLI; low-power laser irradiation; ALP; alkaline phosphatase; BMP2; bone morphogenetic protein 2; Cbfa1; core-binding factor 1; CK1; casein kinase 1; DEX; dexamethasone; GSK3β; glycogen synthase kinase 3β; LATS; large tumor suppressor; MyoD; myogenic di
Photoactivation of Dok1/ERK/PPARγ signaling axis inhibits excessive lipolysis in insulin-resistant adipocytes
Keywords: گیرنده تیروزین کیناز; Akt; protein kinase B; Dex; dexamethasone; Dok1; downstream of tyrosine kinases-1; ERK1/2; extracellular signal-regulated kinase 1 and 2; ap2; fatty acid binding protein 4; IBMX; isobutylmethylxanthine; IRS; insulin receptor substrate; InsR; insulin recep
PI3K/Akt signaling in osteosarcoma
Keywords: گیرنده تیروزین کیناز; OS; osteosarcoma; PI3K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog; mTOR; mammalian target of rapamycin; RTKs; receptor tyrosine kinases; PDGFR; platelet-derived growth factor receptor; IGF1R; insulin-like growth factor 1 receptor
Research reportAntidepressant-like effects of alarin produced by activation of TrkB receptor signaling pathways in chronic stress mice
Keywords: گیرنده تیروزین کیناز; TrkB; tropomyosin-related kinase B; FST; forced swim test; UCMS; unpredictable chronic mild stress; aCSF; artificial cerebrospinal fluid; RTKs; receptor tyrosine kinases; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol 3-kinase; ERK; ex
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents
Keywords: گیرنده تیروزین کیناز; CA-4P; combretastatin A-4 phosphate; VEGFR-2; vascular endothelial growth factor receptor-2; RTKs; receptor tyrosine kinases; 2ME2; 2-methoxyestradiol; PDGFR-β; platelet-derived growth factor receptor β; CAM; chorioallantoic membrane; DDQ; 2,3-dichloro-
Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR
Keywords: گیرنده تیروزین کیناز; CRI; covalent reversible inhibitor; EDC·HCl; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; hydroxybenzotriazole; DIPEA; N,N-diisopropylethylamine; EGFR; epidermal growth factor receptor; NOE; nuclear Overhauser effect; NSCLC; non-sma
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2
Keywords: گیرنده تیروزین کیناز; Tumor angiogenesis; Receptor tyrosine kinases; VEGFR; Kinase inhibitors; Benzothiopyranopirimidines; VEGF; Vascular Endothelial Growth Factor; VEGFR; Vascular Endothelial Growth Factor Receptor; KDR; human kinase insert domain receptor; EGFR; Epidermal Gr