Genetic diseases resulting from disordered FGF23/klotho biology
Keywords: کلوتو; FGF23; Klotho; Hypophosphatemia; Hyperphosphatemia; Tumoral calcinosis; GALNT3; PHEX;
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The chronic kidney disease - Mineral bone disorder (CKD-MBD): Advances in pathophysiology
Keywords: کلوتو; CKD-MBD; Activin; Dickkhopf 1; Klotho; FGF23; Parathyroid hormone; Renal osteodystrophy; Vascular calcification;
Klotho, APOEε4, cognitive ability, brain size, atrophy, and survival: a study in the Aberdeen Birth Cohort of 1936
Keywords: کلوتو; Klotho; Cognitive aging; Brain atrophy; Survival; APOEε4;
TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis
Keywords: کلوتو; CKD; chronic kidney disease; UUO; unilateral ureteral occlusion; TGFβ; transforming growth factor-beta; DNMT; DNA methyltransferase; MTD; myofibroblast trans-differentiation; MSP; methylation-specific PCR; BSP; bisulfite-sequencing PCR; Renal fibrosis; K
Heritable and acquired disorders of phosphate metabolism: Etiologies involving FGF23 and current therapeutics
Keywords: کلوتو; FGF-23; Genetics; Hypophosphatemia; Hyperphosphatemia; Klotho; Tumoral calcinosis;
FGF23-αKlotho as a paradigm for a kidney-bone network
Keywords: کلوتو; Klotho; FGF23; Chronic kidney disease;
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
Keywords: کلوتو; AMPK; Cell non-autonomous; FGF21; Healthspan; Klotho; Lifespan; PERK;
Tissue expression and source of circulating αKlotho
Keywords: کلوتو; Klotho; FGF23; FGF-23;
Is serum Klotho protective against atherosclerosis in patients with type 1 diabetes mellitus?
Keywords: کلوتو; Atherosclerosis; Epicardial fat thickness; Flow mediated dilation; Diabetes mellitus type 1; Klotho
Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes
Keywords: کلوتو; Diabetes; Fibroblast growth factors; Glucose metabolism; Klotho
Enfermedad óseo mineral relacionada con la enfermedad renal crónica: Klotho y FGF23; implicaciones cardiovasculares
Keywords: کلوتو; Riesgo cardiovascular; Enfermedad renal crónica; Klotho; FGF23Cardiovascular risk; Chronic kidney disease; Klotho; FGF23
Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism
Keywords: کلوتو; Klotho; Wound healing; FGF23; TNF-α;
Therapeutic effect of astragaloside-IV on bradycardia is involved in up-regulating klotho expression
Keywords: کلوتو; Klotho; Bradycardia; HCN4; ISO; Astragaloside IV
Update on FGF23 and Klotho signaling
Keywords: کلوتو; FGF23; Fibroblast growth factor-23; Klotho; Bone; Kidney; Parathyroid gland;
Out of the TWEAKlight: Elucidating the Role of Fn14 and TWEAK in Acute Kidney Injury
Keywords: کلوتو; Apoptosis; clinical trials; fibrosis; kidney; klotho; inflammation; mitochondria; necroptosis; therapy; human; acute kidney injury
Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression
Keywords: کلوتو; klotho; methylation of lysine 9 of histone H3; methyltransferase G9a; transforming growth factor-β1; tubulointerstitial fibrosis;
Klotho inhibits angiotensin II-induced cardiomyocyte hypertrophy through suppression of the AT1R/beta catenin pathway
Keywords: کلوتو; Klotho; Hypertrophy; Cardiomyocyte; Wnt; β-catenin; Angiotensin II;
Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells
Keywords: کلوتو; Cigarette smoke; Klotho; Oxidative stress; COPD; Epithelial cells; Aging;
Klotho, a new marker for osteoporosis and muscle strength in β-thalassemia major
Keywords: کلوتو; β-Thalassemia major; Osteoporosis; Fragility fractures; Klotho; Hand-grip strength
Klotho ameliorated isoproterenol-induced pathological changes in cardiomyocytes via the regulation of oxidative stress
Keywords: کلوتو; Cardiomyocytes; Klotho; Oxidative stress; Reactive oxygen species
Soluble αKlotho as a candidate for the biomarker of aging
Keywords: کلوتو; Aging; Klotho; Soluble αKlotho; FGF23; Chronic kidney disease; Osteoporosis; sKlotho; soluble αKlotho; FGF23; fibroblast growth factor 23; FGFR; FGF receptor; CKD; chronic kidney disease; eGFR; estimated glomerular filtration rate; ANOVA; analysis of va
Klotho urinario determinado por ELISA como biomarcador precoz de fracaso renal agudo en pacientes sometidos a cirugía cardiaca o angiografía coronaria
Keywords: کلوتو; Fracaso Renal Agudo; Biomarcadores; Cirugía cardiaca; Angiografía coronaria; Klotho; ELISAAcute kidney injury; Biomarkers; Cardiac surgery; Coronary angiography; Klotho; ELISA
Urinary Klotho measured by ELISA as an early biomarker of acute kidney injury in patients after cardiac surgery or coronary angiography
Keywords: کلوتو; Acute kidney injury; Biomarkers; Cardiac surgery; Coronary angiography; Klotho; ELISAFracaso Renal Agudo; Biomarcadores; Cirugía cardiaca; Angiografía coronaria; Klotho; ELISA
Hypermethylation in gastric cancer
Keywords: کلوتو; 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; APC; adenomatosis polyposis coli; ATP; adenosine-triphosphate; BCL6B; B-Cell CLL/Lymphoma 6, Member B; BGS; bisulfite genomic sequencing; BMP-2; bone morphoge
Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats
Keywords: کلوتو; aorta; Klotho; parathyroid; renal failure; uremic rats; VDRA;
Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis
Keywords: کلوتو; Multiple sclerosis; Klotho; Redox system; FRAP assay;
Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease
Keywords: کلوتو; Aging; Alzheimer's disease; Brain; Cerebrospinal fluid; Klotho;
Bone–kidney axis in systemic phosphate turnover
Keywords: کلوتو; Klotho; FGF23; Kidney; Bone; Vitamin-D
Fibroblast growth factor 23 and Klotho serum levels in healthy children
Keywords: کلوتو; Fibroblast growth factor 23; Klotho; Children; Phosphate;
Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency
Keywords: کلوتو; chronic kidney disease; fibroblast growth factor 23; Klotho; phosphate; vascular calcification;
Laboratory Abnormalities in CKD-MBD: Markers, Predictors, or Mediators of Disease?
Keywords: کلوتو; Calcium; hyperphosphatemia; vitamin D; uremic toxins; FGF23; klotho; PTH
Klotho has dual protective effects on cisplatin-induced acute kidney injury
Keywords: کلوتو; acute kidney injury; cisplatin; glucuronidase; Klotho; nephrotoxicity; organic cation transporter;
Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathway
Keywords: کلوتو; Klotho; Activating transcription factor 3 (ATF3); c-Jun; Resveratrol; Anti-aging;
Expression of FGF23/KLOTHO system in human vascular tissue
Keywords: کلوتو; Human aorta; Fibroblast growth factor 23; KLOTHO; Real time PCR; Gene expression;
ReviewVitamin D: Health panacea or false prophet?
Keywords: کلوتو; Vitamin D; Safety; Klotho; FGF23;
Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma
Keywords: کلوتو; Hepatocellular carcinoma; Klotho; Methylation; Prognosis;
The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice
Keywords: کلوتو; Klotho; Phosphate; Vascular calcification; Insulin; IGF1;
Protective effect of tetrahydroxystilbene glucoside against d-galactose induced aging process in mice
Keywords: کلوتو; Tetrahydroxystilbene glucoside; Anti-aging; Klotho; Glycometabolism;
N-acetylcysteine attenuates renal alterations induced by senescence in the rat
Keywords: کلوتو; Aging kidneys; N-acetylcysteine; Renal function; p53; Oxidative stress; Klotho
A phosphate-centric paradigm for pathophysiology and therapy of chronic kidney disease
Keywords: کلوتو; calciprotein particle (CPP); fibroblast growth factor-23 (FGF23); Klotho; phosphate restriction;
High phosphate feeding induced arterial medial calcification in uremic rats: Roles of Lanthanum carbonate on protecting vasculature
Keywords: کلوتو; Arterial medial calcification; Chronic renal failure; Lanthanum carbonate; Hyperphosphatemia; FGF-23; Klotho
Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium
Keywords: کلوتو; Cd, cadmium; BCd, blood cadmium; UCd, urinary cadmium; NAG, N-acetyl-β-d-glucosaminidase; B2M, β2-microglobulin; Alb, albumin; Scr, serum creatinine; eGFR, estimated glomerular filtration rateCadmium; Hypermethylation; KLOTHO; Pyrosequencing; RASAL1; Rena
Renal and Extrarenal Actions of Klotho
Keywords: کلوتو; Acute kidney injury; cardiac hypertrophy; chronic kidney disease; hyperparathyroidism; Klotho;
A Systems Biology Preview of the Relationships Between Mineral and Metabolic Complications in Chronic Kidney Disease
Keywords: کلوتو; 1,25(OH)2D; bone; kidney; calcium; osteoblasts (Obs); osteocytes; cyp27b1; cyp24; Klotho; FGF23; PTH;
Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein
Keywords: کلوتو; Uremic toxin; Indoxyl sulfate; Endothelial cells; Dysfunction; Klotho;
Klotho modulates the stress response in human senescent endothelial cells
Keywords: کلوتو; Klotho; Human endothelial cells; Cell senescence; Stress-induced premature senescence
Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease
Keywords: کلوتو; 1,25(OH)2D; Bone; Kidney; Calcium; Osteoblasts; Osteocytes; Cyp27b1; Cyp24; Klotho
FGF23/Klotho axis: Phosphorus, mineral metabolism and beyond
Keywords: کلوتو; FGF23; Klotho; Mineral metabolism; Cardiovascular disease; Chronic kidney disease
Fibroblast Growth Factor 23 and the Bone-Vascular Axis: Lessons Learned From Animal Studies
Keywords: کلوتو; Chronic kidney disease (CKD); fibroblast growth factor 23 (FGF-23); klotho; phosphate; vascular calcification;
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet
Keywords: کلوتو; chronic kidney disease; klotho; osteopontin; vascular calcification; vitamin D