کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6020266 | 1580393 | 2015 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis](/preview/png/6020266.png)
چکیده انگلیسی
Recent investigations support that an anti-aging protein, namely Klotho, protects neurons against the oxidative stress and demyelination. We evaluated the protein concentration of Klotho and total anti-oxidant capacity (TAC) in the cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (RRMS). Klotho concentration and TAC were significantly lower in patients as compared to controls. Klotho values showed a significant negative correlation with expanded disability status scale (EDSS). Moreover, a significantly positive correlation between TAC levels and Klotho concentrations was detected. Klotho may play an important role in the pathogenesis of MS, at least in part, through the regulation of redox system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 281, 15 April 2015, Pages 5-8
Journal: Journal of Neuroimmunology - Volume 281, 15 April 2015, Pages 5-8
نویسندگان
Mohammad Sajad Emami Aleagha, Bahaadin Siroos, Mona Ahmadi, Mohammad Balood, Alireza Palangi, Afsaneh Nazari Haghighi, Mohammad Hossein Harirchian,