The Role of Fixed-Dose Dual Bronchodilator Therapy in Treating COPD
Keywords: سود; Bronchodilation; COPD; LABA; LAMA;
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Tiotropium Attenuates Refractory Cough and Capsaicin Cough Reflex Sensitivity in Patients with Asthma
Keywords: سود; Chronic asthmatic cough; Capsaicin cough reflex sensitivity; Tiotropium; Cough severity; Cough-specific quality of life; ACT; Asthma Control Test; ICS; Inhaled corticosteroids; J-LCQ; Japanese version of Leicester Cough Questionnaire; LABA; Long-acting β
Changes in Asthma Maintenance Therapy Prescribing Patterns Following the 2006 Long-acting β-Agonist FDA Drug Warning
Keywords: سود; asthma; LABA; prescribing patterns; warning;
Forced oscillation technique as a predictor of FEV1 improvement in asthma
Keywords: سود; AIC; Akaike's information criteria; ALX; low-frequency reactance area; Î; differences between inspiratory and expiratory phases; FeNO; fractional exhaled nitric oxide; FEV1; forced expiratory volume in one second; FOT; forced oscillation technique; Fre
Assessing usability of the “Adherence Starts with Knowledge 20” (ASK-20) questionnaire for Japanese adults with bronchial asthma receiving inhaled corticosteroids long term
Keywords: سود; Adherence; ASK-20; Asthma; Reliability; Validity; ACT; Asthma Control Test; ASK-20; Adherence Starts with Knowledge 20; CI; confidence interval; ICS; inhaled corticosteroid; LABA; long-acting beta-agonist; MARS; Medication Adherence Rating Scale; MMAS; Mo
Long-term general and cardiovascular safety of tiotropium/olodaterol in patients with moderate to very severe chronic obstructive pulmonary disease
Keywords: سود; COPD; Long-acting muscarinic antagonist; Long-acting β-agonist; Safety; Maintenance bronchodilator; AE; adverse event; COPD; chronic obstructive pulmonary disease; GOLD; Global initiative for chronic Obstructive Lung Disease; LABA; long-acting β2-agonis
Long-term safety and efficacy of combined tiotropium and olodaterol in Japanese patients with chronic obstructive pulmonary disease
Keywords: سود; AE; adverse event; AUC0-3; area under the curve from 0 to 3Â h; COPD; chronic obstructive pulmonary disease; FEV1; forced expiratory volume in 1Â s; FVC; forced vital capacity; GOLD; Global initiative for chronic Obstructive Lung Disease; ICH-E1; Intern
Review articleImpact of LABA/LAMA combination on exercise endurance and lung hyperinflation in COPD: A pair-wise and network meta-analysis
Keywords: سود; COPD; Exercise; LABA; LAMA; Combination; Meta-analysis; COPD; chronic obstructive pulmonary disease; CPET; cardiopulmonary exercise test; ET; endurance time; ESWT; endurance shuttle walking test; FDC; fixed-dose combinations; FEV1; forced expiratory volum
Long-Acting β-Agonist in Combination or Separate Inhaler as Step-Up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids
Keywords: سود; Asthma; Child; Inhaled corticosteroid; Long-acting β-agonist; Step-up therapy; aOR; Adjusted odds ratio; aRR; Adjusted rate ratio; BDP; Beclomethasone dipropionate; BTS/SIGN; The British Thoracic Society and Scottish Intercollegiate Guidelines Network; C
Long-Acting Bronchodilator Initiation in COPD and the Risk of Adverse Cardiopulmonary Events
Keywords: سود; long-acting anticholinergic; long-acting β-agonists; community-acquired pneumonia; epidemiology; CPRD; Clinical Practice Research Datalink; HDPS; high-dimensional propensity score; HES; Hospital Episodes Statistics; HR; hazard ratio; ICS; inhaled cortico
Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule
Keywords: سود; COPD; Bronchodilator; Long-acting β2-adrenoceptor agonist; Long-acting muscarinic antagonist; ACh; acetylcholine; ANOVA; analysis of variance; β; beta-adrenoceptor; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary; CI; confidence interva
Baseline Symptom Score Impact on Benefits of Glycopyrrolate/Formoterol Metered Dose Inhaler in COPD
Keywords: سود; bronchodilators; chronic bronchitis; combination therapy; emphysema; metered dose inhalers; CAT; COPD Assessment Test; FF; formoterol fumarate; GFF; glycopyrrolate/formoterol fumarate; GOLD; Global Initiative for Chronic Obstructive Lung Disease; GP; glyc
A phase III randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthma
Keywords: سود; Anticholinergic drug; asthma; asthma control; children; efficacy; FEV1; lung function; Respimat; safety; tiotropium; ACQ-IA; Interviewer-administered Asthma Control Questionnaire; FEF25-75; Forced expiratory flow at 25% to 75% of the forced vital capacity
Efficacy and Safety of Glycopyrrolate/Formoterol Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Patients With COPD
Keywords: سود; β2-agonist; bronchodilator; chronic bronchitis; emphysema; muscarinic antagonists; AE; adverse event; ATS; American Thoracic Society; CAT; COPD Assessment Test; DPI; dry powder inhaler; FDC; fixed-dose combination; FEV1 AUC0-12; FEV1 area under the curv
Efficacy and safety of indacaterol/glycopyrronium in Japanese patients with COPD: Pooled analysis of SHINE and ARISE
Keywords: سود; AE; adverse event; CCV; cerebro-cardiovascular; CI; confidence interval; DPI; dry powder inhaler; ECG; electrocardiography; FEV1; forced expiratory volume in one second; FVC; forced vital capacity; GOLD; Global Initiative for Chronic Obstructive Lung Dise
Socioeconomic inequalities in adherence to inhaled maintenance medications and clinical prognosis of COPD
Keywords: سود; SES; Compliance; Proportion of days covered (PDC); Exacerbations; Admissions; Medicine; LAMA; LABA; ICS; Registries; aHR; adjusted hazard ratio; aRR; adjusted relative risk; ATC; Anatomic Therapeutic Chemical; BMI; Body Mass Index; COPD; chronic obstructi
The Inaccuracy of Patient Recall for COPD Exacerbation Rate Estimation and Its Implications
Keywords: سود; adjudication committee; COPD; end point; exacerbation; outcome measurement error; sample size; AC; adjudication committee; CRQ; Chronic Respiratory Questionnaire; GOLD; Global Initiative for Chronic Obstructive Lung Disease; HADS; Hospital Anxiety and Dep
A multicenter, randomized, double-blind dose-ranging study of glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler compared to the monocomponents and open-label tiotropium dry powder inhaler in patients with moderate-to-severe CO
Keywords: سود; Bronchodilators; Fixed-dose combinations; LAMA; LABA; Co-Suspension⢠Delivery Technology; COPD maintenance therapy;
Optimal treatment sequence in COPD: Can a consensus be found?
Keywords: سود; COPD; Treatment sequence; SABA; SAMA; LABA; LAMA; ICS; Triple therapy; Non-inhaled therapies
Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment
Keywords: سود; Adrenergic receptors; asthma; child; disease exacerbation; therapeutics; ADRB2; β2-Adrenoceptor gene; GALA II; Genes-Environments and Admixture in Latino Americans; HWE; Hardy-Weinberg equilibrium; ICS; Inhaled corticosteroid; LABA; Long-acting β-agonis
Characteristics and Outcomes of HEDIS-Defined Asthma Patients with COPD Diagnostic Coding
Keywords: سود; Asthma; Asthma control; Asthma guidelines; Asthma impairment; Asthma risk; COPD; Eosinophils; GINA step-care level; Managed care; ACOS; Asthma-COPD overlap syndrome; AS-COPD; Persistent asthma patients with ICD-9 diagnosis codes for chronic bronchitis, em
Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma
Keywords: سود; Asthma; roflumilast; montelukast; phosphodiesterase 4 inhibitors; ACQ; Asthma Control Questionnaire; AE; Adverse event; ANCOVA; Analysis of covariance; ATS; American Thoracic Society; BMI; Body mass index; COPD; Chronic obstructive pulmonary disease; C-SS
Tiotropium add-on therapy in adolescents with moderate asthma: AÂ 1-year randomized controlled trial
Keywords: سود; Adolescent; anticholinergic drug; asthma; asthma control; efficacy; FEV1; lung function; Respimat; safety; tiotropium; ACQ-6; 6-question Asthma Control Questionnaire; ACQ-7; 7-question Asthma Control Questionnaire; AQLQ(S)+12; Asthma Quality of Life Quest
Acute Exacerbations of COPD Are Associated With Increased Expression of Heparan Sulfate and Chondroitin Sulfate in BAL
Keywords: سود; airway inflammation; airway obstruction; bronchoalveolar lavage; COPD; AECOPD; acute exacerbation of COPD; CV; coefficient of variability; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; GAG; glycosaminoglycan; ICS; inhaled corticoste
Long-term safety of aclidinium bromide/formoterol fumarate fixed-dose combination: Results of a randomized 1-year trial in patients with COPD
Keywords: سود; Aclidinium; Formoterol; LAMA; Muscarinic antagonist; LABA; COPD;
Computed tomography (CT)-assessed bronchodilation induced by inhaled indacaterol and glycopyrronium/indacaterol in COPD
Keywords: سود; Bronchodilation; β2 agonists; Anticholinergics; Pulmonary function tests; Three-dimensional computed tomography; Ai; airway inner luminal area; BMI; body mass index; COPD; chronic obstructive pulmonary disease; CT; computed tomography; DLco; diffusing ca
Pharmacological interaction between LABAs and LAMAs in the airways: optimizing synergy
Keywords: سود; LABA; LAMA; COPD; Drug interaction; Dual bronchodilation; Translation research; Airways smooth muscle; Clinical trials;
Asthma and lower airway diseaseThe Xolair Pregnancy Registry (EXPECT): The safety of omalizumab use during pregnancy
Keywords: سود; Omalizumab; pregnancy; moderate-to-severe persistent allergic asthma; HCP; Health care provider; ICS; Inhaled corticosteroids; LABA; Long-acting β2-agonist; MACDP; Metropolitan Atlanta Congenital Defects Program; SGA; Small for gestational age; US; Unite
Roflumilast added to triple therapy in patients with severe COPD: AÂ real life study
Keywords: سود; COPD exacerbations; Phosphodiesterase-4 inhibitors; Combination therapy; Side effects; AECOPD; acute exacerbation of COPD; ICS; inhaled corticosteroids; LABA; long-acting β-agonist; LAMA; long-acting muscarinic antagonist; PDE-4; phosphodiesterase-4;
Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma
Keywords: سود; Asthma; Phenotype; Eosinophils; Airway inflammation; FeNO; Mannitol; AHR; Airway hyperresponsiveness; RDR; Response dose ratio; FeNO; Fractional exhaled nitric oxide; ICS; Inhaled corticosteroid; LABA; Long-acting beta 2-agonist; PEF; Peak-flow variabilit
The Relationship of the Fibrinogen Cleavage Biomarker Aa-Val360 With Disease Severity and Activity in α1-Antitrypsin Deficiency
Keywords: سود; AAT; α1-rantitrypsin; AATD; α1-cantitrypsin deficiency; CAT; COPD assessment tool; IQR; interquartile range; Kco; transfer coefficient; LABA; long-acting à agonist; NE; neutrophil elastase; SGRQ; St. George's Respiratory Questionnaire;
Factors Predictive of Airflow Obstruction Among Veterans with Presumed Empirical Diagnosis and Treatment of COPD
Keywords: سود; AFO; airflow obstruction; CHF; congestive heart failure; HTN; hypertension; ICD-9; International Classification of Diseases, Ninth Revision; ICS; inhaled corticosteroid; LABA; long-acting β-agonist; RR; relative risk; VA; US Department of Veterans Affair
Tiotropium + olodaterol shows clinically meaningful improvements in quality of life
Keywords: سود; COPD; Quality of life; Long-acting bronchodilator; Tiotropium; Olodaterol; AE; adverse event; AUC0-3; area under the curve from 0 to 3Â h; COPD; chronic obstructive pulmonary disease; FEV1; forced expiratory volume in 1Â s; GOLD; Global initiative for c
Efficacy and safety of umeclidinium added to fluticasone furoate/vilanterol in chronic obstructive pulmonary disease: Results of two randomized studies
Keywords: سود; Long-acting muscarinic antagonist; Inhaled corticosteroid; Long-acting beta2 agonist; Bronchodilation; AE; adverse event; ASE; all subjects enrolled; CAT; COPD Assessment Test; CI; confidence interval; COPD; chronic obstructive pulmonary disease; FEV1; fo
Risk of congenital malformations for asthmatic pregnant women using a long-acting β2-agonist and inhaled corticosteroid combination versus higher-dose inhaled corticosteroid monotherapy
Keywords: سود; Asthma; pregnancy; congenital malformations; inhaled corticosteroid; long-acting β2-agonist; combination therapy; high-dose inhaled corticosteroid; cohort study; comparative safety study; administrative health databases; ICD-9; International Classificati
Characterization of V0162, a new long-acting antagonist at human M3 muscarinic acetylcholine receptors
Keywords: سود; ACh; acetylcholine; COPD; chronic obstructive pulmonary disease; EFS; electrical field stimulation; hM3R; human muscarinic M3 acetylcholine receptor; KHS; Krebs-Henseleit solution; LABA; long-acting beta adrenergic agonist; LAMA; long-acting muscarinic
Economic Burden of COPD in the Presence of Comorbidities
Keywords: سود; CKD; chronic kidney disease; CVD; cardiovascular disease; GLM; generalized linear model; ICS; inhaled corticosteroid; LABA; long-acting β2-adrenergic agonist; LAMA; long-acting muscarinic antagonist; MI; myocardial infarction;
Symptom- and fraction of exhaled nitric oxide-driven strategies for asthma control: AÂ cluster-randomized trial in primary care
Keywords: سود; Quality of life; fraction of exhaled nitric oxide; asthma exacerbations; asthma control; cost-effectiveness; online decision support; ACQ; Asthma Control Questionnaire; Ca; Controlled asthma; EQ-5D; EuroQol classification system; FCa; Feno-driven controll
IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism
Keywords: سود; IL-13; cAMP; phosphatidylethanolamine binding protein 1; 15-lipoxygenase 1; β2-adrenergic receptor; G protein receptor kinase 2; asthma; ALI; Air-liquid interface; ALOX15; Arachidonate 15-lipoxygenase; β2AR; β2-Adrenergic receptor; cAMP; Cyclic adenosi
A Systematic Review of the Efficacy and Safety of a Fixed-Dose Combination of Umeclidinium and Vilanterol for the Treatment of COPD
Keywords: سود; AE; adverse event; FSC; fluticasone propionate/salmeterol; ICS; inhaled corticosteroid; LABA; long-acting Ã2-agonist; LAMA; long-acting muscarinic antagonist; MCID; minimal clinically important difference; NNTB; number needed to treat for benefit; SAE; s
Discovery of TD-4306, a long-acting β2-agonist for the treatment of asthma and COPD
Keywords: سود; β2-Adrenoceptor agonist; Inhaled; LABA; Bronchodilator; Multivalent approach;
Multivalent design of long-acting β2-adrenoceptor agonists incorporating biarylamines
Keywords: سود; β2-Adrenoceptor agonist; Inhaled; LABA; Bronchodilator; Multivalent approach
Impact of an integrated disease management program in reducing exacerbations in patients with severe asthma and COPD
Keywords: سود; Asthma; COPD; Exacerbations; Disease management program; Healthcare utilization; Spirometry; All-ER; all cause emergency room visits; All-HA; all cause hospitalizations; BNP; Brain Natriuretic Peptide; CHF; congestive heart failure; CLDP; Chronic Lung Dis
Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A
Keywords: سود; Long-acting β2-agonist; salmeterol; formoterol; salbutamol; asthma; allergy; rhinovirus; exacerbation; chemokine; dexamethasone; (S)-2-amino-4-(4-[heptyloxy]phenyl)-2-methylbutan-1-ol; protein phosphatase 2A; nuclear factor κB; AAD; Allergic airways dis
COPD assessment tests scores are associated with exacerbated chronic obstructive pulmonary disease in Japanese patients
Keywords: سود; ATS; American Thoracic Society; BMI; body mass index; CAT; COPD assessment test; COPD; chronic obstructive pulmonary disease; ERS; European Respiratory Society; FEV1; forced expiratory volume in 1Â s; FVC; forced vital capacity; GOLD; Global Initiative fo
Efficacy and safety of umeclidinium/vilanterol 62.5/25Â mcg and tiotropium 18Â mcg in chronic obstructive pulmonary disease: Results of a 24-week, randomized, controlled trial
Keywords: سود; Long-acting bronchodilator; Umeclidinium; Vilanterol; AE; adverse event; CI; confidence interval; COPD; chronic obstructive pulmonary disease; DPI; Dry powder inhaler; FEV1; forced expiratory volume in one second; FP; fluticasone propionate; FVC; forced v
Predictors of Severe Exacerbations, Poor Asthma Control, and β-Agonist Overuse for Patients with Asthma
Keywords: سود; Asthma; β-agonist; Electronic monitoring; Predictors; Risk; ACQ; Asthma Control Questionnaire; ICS; Inhaled corticosteroid; IQR; Interquartile range; LABA; Long-acting β-agonist; MDI; Metered-dose inhaler; RR; Rate ratio; SMART; Single budesonide-formot
Efficacy and Safety of a Fixed-Dose Combination of Indacaterol and Glycopyrronium for the Treatment of COPD
Keywords: سود; AE; adverse event; LABA; long-acting β2-agonist; LAMA; long-acting muscarinic antagonist; MCID; minimal clinical important difference; NNTB; number needed to treat for benefit; QVA149; fixed-dose combination of indacaterol and glycopyrronium; SAE; seriou
Long-Acting Bronchodilators and Arterial Stiffness in Patients With COPD
Keywords: سود; AE; adverse event; AIx; augmentation index; aPWV; aortic pulse wave velocity; CVD; cardiovascular disease; FF/VI; fluticasone furoate/vilanterol; ICS; inhaled corticosteroid; ITT; intent-to-treat; LABA; long-acting β-agonist; LOCF; last observation carri
Clinical Burden and Predictors of Asthma Exacerbations in Patients on Guideline-based Steps 4-6 Asthma Therapy in the TENOR Cohort
Keywords: سود; Severe or difficult-to-treat asthma; Uncontrolled asthma; Exacerbations; Asthma therapy; Asthma guidelines; Anti-asthmatic agents; BMI; Body mass index; COPD; Chronic obstructive pulmonary disease; ED; Emergency department; EPR-3; Expert Panel Report 3; F