Keywords: CSC; cancer stem cells; EMT; epithelial to mesenchymal transition; MET; mesenchymal to epithelial transition; AML; acute myeloid leukemia; ALDH1; aldehyde dehydrogenase 1; BCSC; breast cancer stem cell; Lgr5; G-protein-coupled receptor 5; GSC; glioblastom
مقالات ISI (ترجمه نشده)
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Keywords: Necrotizing enterocolitis; Liver injury; Hepatic progenitor cell; LGR5;
Keywords: 5-FU; 5-Fluorouracil; ABCB5; ATP-binding cassette sub-family B member 5; ABCC2; ATP-binding cassette sub-family C member 2; ABCG2; ATP-binding cassette sub-family G member 2; ACs; Anthocyanins; ALDH; aldehyde dehydrogenase; AML; acute myeloid leukemia; AP
Keywords: AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; ADAM; a disintegrin and metalloproteinase enzymes; ALDH; aldehyde dehydrogenase; ABC; ATP - binding cassette; BWS; Beckwith-Wiedemann syndrome; BMP; bone morphogenetic proteins; CSC; cancer s
Keywords: Enteroids; Methionine; Stem cells; Differentiation; Lgr5; Chromogranin A;
Keywords: Colorectal cancer; cancer stem cell; immunohistochemistry; ALDH1; CD44v6; CD133; Lgr5; SOX2;
Keywords: Deep infiltrating endometriosis (DIE); epithelial mesenchymal transition (EMT); LGR5; macrophages; uterine aspirate;
Keywords: Intestinal Stem Cell; LGR5; Small Intestine; Calorie Restriction; Enteric Nutrition; Mechanoluminal Flow; ISC; intestinal stem cell; mRNA; messenger RNA; NEC; necrotizing enterocolitis; PCR; polymerase chain reaction; qPCR; quantitative polymerase chain r
Keywords: Liver Stem Cells; LGR5; Quiescent Stem Cells; Proliferative Stem Cells; BrdU; Bromodeoxyuridine; CCl4; carbon tetrachloride; dox; doxycycline; DT; diphtheria toxin; DTR; diphtheria toxin receptor; FACS; fluorescence-activated cell sorter; GFP; green fluor
Keywords: 2-DG; 2-deoxyglucose; 2-HG; 2-hydroxyglutarate; 5mC; 5-methlycystosine; ACACA; acetyl-CoA carboxylase; AML; acute myeloid leukemia; AMPK; adenosine monophosphate-activated protein kinase; ATP; adenosine triphosphate; ALDH; aldehyde dehydrogenase; ADCs; an
Keywords: Biomarkers; BMI1; LGR5; MSI1; SOX9;
Keywords: Anti-cancer therapies; Cancer attractors; Cancer stem cells; Hypoxia; Inflammation; Interactome; Metabolic modeling; Networks; Senescence; Signaling; AKT; RAC-alpha serine/threonine protein kinase; BMI1; polycomb ring finger oncogene; C/EBP; CCAAT/enhance
Keywords: Epithelial; Stem cells; Lgr5; Intestinal cancer; Organoids;
Keywords: CD117; Stem Cell Factor; Colorectal Cancer; Enteroids; Cy; cyanine; FACS; fluorescence-activated cell sorting; LGR5; leucine-rich repeat-containing G-protein coupled receptor 5; NSG; NOD-scid IL2Rgnull; qRT-PCR; quantitative reverse transcription polymer
Keywords: CBC; crypt base columnar; TA; transit amplifying; GFP; green fluorescence protein gene; Lgr5; leucine-rich-repeat-containing G-protein-coupled receptor 5; OLFM4; Olfactomedin 4; Imaging of a single stem cell; Intestinal stem cells; Long-lived stem cells;
Keywords: CSC; cancer stem cells; PDAC; pancreatic ductal adenocarcinoma; TSC; tissue stem cells; Insulin; Diabetes; β cells; KRAS; LGR5; Nanog;
Keywords: hBTSCs; human biliary tree stem cells; PBG; peribiliary gland; hGSC; human gallbladder stem/progenitor cells; PAS; Periodic Acid Schiff; R-A; Rokitansky-Aschoff; EpCAM; epithelial cell adhesion molecule; PCNA; Proliferating Cell Nuclear Antigen; LGR5; leu
Keywords: Foxl2; Lgr5; Nr2f2; Rspo1; Wnt4; Ovary;
Keywords: Atoh1; Atonal homolog 1; MC; mucinous colon cancer; SRCC; signet ring cell carcinoma; GSK3; glycogen synthase kinase 3; Lgr5; Leucine-rich repeat-containing G-protein coupled receptor 5; IEC; intestinal epithelial cells; MUC2; mucin 2; TFF3; trefoil facto
Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 predicts poor prognosis in hepatocellular carcinoma
Keywords: Liver cancer; LGR5; Immunohistochemistry; Clinicopathology; Overall survival; HBs; hepatitis B virus; EMT; epithelial-to-mesenchymal transition; Flot2; flotillin-2; GPCR; G-protein-coupled receptor; GPR49; G-protein coupled receptor 49; GRP78; glucose-reg
ALDH1A1 positive cells are a unique component of the tonsillar crypt niche and are lost along with NGFR positive stem cells during tumourigenesis
Keywords: ALDH1A1; NGFR; LGR5; aldehyde dehydrogenase; HPV; tonsillar crypts; OPSCC;
Comparison of ex vivo and in vitro intestinal cystic fibrosis models to measure CFTR-dependent ion channel activity
Keywords: A; amiloride; AUC; area-under-the-curve; cAMP; cyclic AMP; CCH; carbachol; CF; cystic fibrosis; CFTR; cystic fibrosis transmembrane conductance regulator; D; differentiation culture conditions; DMSO; dimethylsulfoxide; ENaC; epithelial sodium channel; FIS
The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids
Keywords: Enteroid; Intestinal stem cells; Lgr5; LPA; Octadecyl thiophosphate; Radiation; Radioprotection; Radiomitigation; LPA; lysophosphatidic acid; ARS; acute radiation syndrome; Lgr5; leucine-rich repeat-containing G protein-coupled receptor 5; OTP; octadecyl
Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine
Keywords: Mouse Model; Type 2 Diabetes; Enteroendocrine Cells; Signal Transduction; CCK; cholecystokinin; Ctgf; connective tissue growth factor; Cyr61; cysteine-rich angiogenic inducer 61; Dll1; delta-like protein 1; DBZ; dibenzazepine; EdU; 5-ethynyl-2â²-deoxyuri
Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine
Keywords: Cystic Fibrosis; Dishevelled; Organoids; Intracellular pH; Neoplasia; CBC; crypt-base columnar cell; CCH; carbachol; CF; cystic fibrosis; Cftr; cystic fibrosis transmembrane conductance regulator; DEP; Dishevelled, Egl-10, and Pleckstrin; Dvl; Dishevelled
Cholangiocytes: Cell transplantation
Keywords: ALDH; Aldehydedehydrogenase; CD; Cluster differentiation; EGF; Epidermal growth factor; EpCAM; Epithelial cell adhesion molecule; ECM; Extracellular matrix; FGF; Fibroblast growth factor; GMP; Good manufacturing practice; G-CSF; Granulocyte colony-stimula
Jade family PHD finger 3 (JADE3) increases cancer stem cell-like properties and tumorigenicity in colon cancer
Keywords: JADE3; Colon cancer; Cancer stem cells; Tumorigenesis; LGR5;
Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells
Keywords: Intestinal stem cells; Lgr5; BLT sandwich culture; Integrin α2β1;
Directional delivery of RSPO1 by mesenchymal stem cells ameliorates radiation-induced intestinal injury
Keywords: Mesenchymal stem cell; R-spondin1; LGR5; Intestinal crypt stem cells; Irradiation;
The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models
Keywords: Gastric Cancer; Stem Cell; Stem Cell Niche; Lgr5; Mist1; CCK2R; CCK2R; cholecystokinin receptor 2; IM; intestinal metaplasia; SPEM; spasmolytic polypeptide-expressing metaplasia;
On the shoulders of Hubrecht: From embryos to stem cells
Keywords: Hubrecht Institute; Developmental Biology; Nuclear reprogramming; Hox genes; Axial elongation; Human embryonic stem cells; piRNA; PIWI; DNA damage; Protein phosphatase inhibitors; Adult stem cells; Wnt; Lgr5; Liver; Stomach; Organoids;
Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells
Keywords: Helicobacter pylori; CD44v9; CD44v6; Inflammation; Cag; cytotoxin-associated gene; CD; cluster-of-differentiation; CD44v9; CD44 variant isoform containing exon v9; CSC; cancer stem cell; Lgr5; leucine-rich, repeat-containing, G-protein-coupled receptor
Leucine-rich repeat-containing G-protein-coupled receptor 5-positive cells in the endometrial stem cell niche
Keywords: Somatic stem cells; human endometrium; stem cell marker; LGR5; hematopoietic lineage;
FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells
Keywords: Gastric cancer; Cancer stem cell; FOXO1; LGR5;
Lgr5 regulates the regeneration of lesioned nasal respiratory epithelium
Keywords: Lgr5; Nasal respiratory epithelium; Regeneration; Stem/progenitor cells; Basal cells;
Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells
Keywords: CRC; colorectal cancer; APC; adenomatous polyposis coli; 1,25-D3; 1,25-dihydroxyvitamin D3; CYP24A1; 1,25-D3 24-hydroxylase; 25(OH)2D3; 25-dihydroxyvitamin D3; TCF; T-cell factor; FAP; familial adenomatous polyposis; LGR5; leucine-rich G-protein coupled r
Original ArticleAppendagesActivating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth
Keywords: Axin2; Axis inhibition protein 2; HF; hair follicle; Lgr5; leucine-rich repeat-containing G-protein coupled receptor 5; PWD; post-wax day; Rspo2; R-spondin; Xgal; x-galactosidase;
“Fibrous nests” in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome
Keywords: α-SMA; alpha smooth muscle actin; DKK; Dickkopf; ECM; extracellular matrix; FNH; focal nodular hyperplasia; FZD; frizzled; GSE; gene expression series; GSK3B; glycogen synthase kinase 3 beta; HCC; hepatocellular carcinoma; iPS cells; induced pluripotent
Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt
Keywords: MicroRNA; Colon stem cells; Lgr5; Colon cancer; Chemoprevention; Diet
Enterohemorrhagic Escherichia coli Reduces Mucus and Intermicrovillar Bridges in Human Stem Cell-Derived Colonoids
Keywords: Human Colonoid Monolayers; Intestinal Organoids; Microvillar Effacement; Serine Protease EspP; A/E; attaching and effacing; BB; brush border; CCS; cold chelating solution; CM; complete medium; 3D; three dimensional; EHEC; enterohemorrhagic Escherichia col
LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation
Keywords: Pluripotent Stem Cells; Endoderm; LGR5; WNT; Organoid; Intestine; CDX2; caudal type homeobox2; ChIPseq; chromatin immunoprecipitation sequencing; creER; cre recombinase protein fused to estrogen receptor; Ct; cycle threshold; DE; definitive endoderm; E; e
The role of LGR5 and ALDH1A1 in non-small cell lung cancer: Cancer progression and prognosis
Keywords: LGR5; ALDH1A1; NSCLC; Clinical pathology; Prognosis
Tissue specific loss of A-type lamins in the gastrointestinal epithelium can enhance polyp size
Keywords: Lamins; LoxP; Villin-Cre; Gastrointestinal cancer; Lgr5
NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling
Keywords: APC; adenomatous polyposis coli; BAC; bacterial artificial chromosome; CBC; crypt base columnar; Cp; crossing point; CRC; colorectal carcinoma; CTNNB1; the β-CATENIN gene; Dvl; dishevelled; EGFP; enhanced green fluorescent protein; EphB2; ephrin type-B r
A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5
Keywords: LGR5; Transgenic mouse; Skin; Sebaceous gland; Wnt/PCP signalling; Hair follicle;
Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands
Keywords: Progenitor Cells; Infection; CagA; Proliferation; 3D; 3-dimensional; GFP; green fluorescent protein; Lgr5; leucine-rich repeat-containing G-protein coupled receptor 5; mRNA; messenger RNA; TFSS; type IV secretion system; WT; wild type;
Transcriptome profiling of LGR5 positive colorectal cancer cells
Keywords: Colorectal cancer; Lgr5; Expression profiling
Expression of Lgr5, a marker of intestinal stem cells, in colorectal cancer and its clinicopathological significance
Keywords: Colorectal cancer; Lgr5; Cancer stem cells; β-catenin; Prognosis
LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/β-catenin signaling pathway in colorectal cancer cells
Keywords: LGR5; Apoptosis; Wnt/β-catenin signaling; Colorectal cancer;
Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway
Keywords: BMP; bone morphogenetic protein; BMPR; BMP receptor; BrdU; bromodeoxyuridine; CBC; crypt-base columnar; GSK3β; glycogen synthase kinase 3β; HIEC; human intestinal epithelial crypt; LGR5; leucine-rich-repeat-containing G-protein-coupled receptor-5; OLFM4