دانلود مقالات ISI درباره دامنه اتصال لیگاند + ترجمه فارسی

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

Keywords: دامنه اتصال لیگاند; PPAR gamma; Nuclear receptor; Natural product; Nutrition; Diabetes; 9-(S)-HODE; (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid; AF-2; activation function-2; CAP; c-Cbl-associated protein; Cdk5; cyclin-dependent kinase 5; DCM; dichloromethane; DIO; diet

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-α

Keywords: دامنه اتصال لیگاند; PPAR; peroxisome proliferator-activated receptor; LBD; ligand-binding domain; SPR; surface plasmon resonance; TR-FRET; time-resolved fluorescent resonance energy transfer; TG; triglyceride; HTG; hypertriglyceridemia; RXR; retinoid X receptor; EO; essentia

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2014 سفارش ترجمه

Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes

Keywords: دامنه اتصال لیگاند; LXR; liver X receptor; LBD; ligand-binding domain; RXR; retinoid X receptor; KD; equilibrium dissociation constant; EC50; the half maximal effective concentration; SPR; surface plasmon resonance; TR-FRET; time-resolved fluorescent resonance energy transfe

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Honokiol: A non-adipogenic PPARγ agonist from nature

Keywords: دامنه اتصال لیگاند; AMPK; AMP-activated kinase; ANOVA; analysis of variance; ATCC; American type culture collection; BADGE; bisphenol A diglycidyl ether; BMP; bone morphogenic protein 4; BSA; bovine serum albumin; CMCNa; sodium carboxymethyl cellulose; DMEM; Dulbecco's modif

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR

Keywords: دامنه اتصال لیگاند; AhR; aryl hydrocarbon receptor; BaP; benzo[a]pyrene; BaPD; (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene; BaPDE; (±)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; BcP; benzo[c]phenanthrene; BcPD; (±)-trans-3,4-dihydroxy-3,4-dihyd

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor

Keywords: دامنه اتصال لیگاند; 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 25(OH)D3; 25-hydroxyvitamin D3; ALOX5; arachidonate 5-lipoxygenase; AR; androgen receptor; CAMP; cathelicidin anti-microbial peptide; CCNC; cyclin C; CDKN1A; cyclin-dependent kinase inhibitor 1A; CoA; co-activato

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Multidomain sumoylation of the ecdysone receptor (EcR) from Drosophila melanogaster

Keywords: دامنه اتصال لیگاند; 20E; 20-hydroxyecdysone; DBD; DNA-binding domain; EcR; ecdysone receptor; HEK293; human embryonic kidney 293 cells; ID; intrinsically disordered; LBD; ligand-binding domain; MS; mass spectrometry; NR; nuclear receptor; RXR; retinoid X receptor; SUMO; smal

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines

Keywords: دامنه اتصال لیگاند; ACh; acetylcholine; nAChR; nicotinic acetylcholine receptor; BA; benzylidene anabaseine; RD; residual desensitization; Ds; PAM-sensitive desensitization; Di; PAM-insensitive desensitization; PAM; positive allosteric modulator; LBD; ligand-binding domain;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery

Keywords: دامنه اتصال لیگاند; FXR; farnesoid X receptor; NRs; nuclear receptors; HTS; high-throughput screen; LBD; ligand-binding domain; TR-FRET; time resolved fluorescence resonance energy transfer;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Characterization of a naturally occurring degradation product of the LDL receptor

Keywords: دامنه اتصال لیگاند; Cleavage; Degradation; Ligand-binding domain; LDL receptor; Truncation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells

Keywords: دامنه اتصال لیگاند; ABC; ATP-binding cassette transporter; FAS; fatty acid synthase; HDL; high-density lipoprotein; LBD; ligand-binding domain; LDL; low-density lipoprotein; LXR; liver X receptor; NPC1L1; Niemann-Pick C1 Like 1; SCD-1; stearoyl-CoA desaturase 1; SPR; surface

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Design, synthesis and in vitro evaluation of a series of α-substituted phenylpropanoic acid PPARγ agonists to further investigate the stereochemistry-activity relationship

Keywords: دامنه اتصال لیگاند; NR; nuclear receptor; hPPAR; human peroxisome proliferator-activated receptor; RXR; retinoid X receptor; LBD; ligand-binding domain; PDB; protein data bank; Peroxisome proliferator-activated receptor; PPAR; PPARγ; Phenylpropanoic acid; SAR;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability

Keywords: دامنه اتصال لیگاند; CHX; cycloheximide; CK2; protein kinase CK2; DBD; DNA-binding domain; DCOH; dimerization cofactor for hepatocyte nuclear factor 1; GST; glutathione S-transferase; LBD; ligand-binding domain; Pin1; peptidyl-prolyl cis/trans isomerase 1; PPIase; Peptidyl-pr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Androgen receptor-mediated gene repression

Keywords: دامنه اتصال لیگاند; AR; androgen receptor; AR wt; wild type androgen receptor; ARE; androgen response element; nARE; negative androgen response element; pARE; positive androgen response element; AP-1; activator protein-1; αBE; α basal element; BrCa; breast cancer; CBP; CRE

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

The retinoid X receptors and their ligands

Keywords: دامنه اتصال لیگاند; Coactivator; Corepressor; Ligand; Ligand-binding domain; Retinoid X receptor; RXR;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2012 سفارش ترجمه

PTOV1 antagonizes MED25 in RAR transcriptional activation

Keywords: دامنه اتصال لیگاند; NR; nuclear receptor; RAR; retinoic acid receptor; AtRA; all-trans retinoic acid; RXR; retinoid X receptor; CBP; CREB-binding protein; MED25; mediator protein 25; PTOV; prostate tumor over-expressed; DBD; DNA-binding domain; LBD; ligand-binding domain; GS

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Interaction of the N-terminus of ecdysone receptor isoforms with the ligand-binding domain

Keywords: دامنه اتصال لیگاند; Aa; amino acid; AF; activation function; AR; androgen receptor; CFP; cyan fluorescent protein; DBD; DNA binding domain; EcR; ecdysone receptor; EcRE; ecdysone response element; ER; estrogen receptor; FRET; fluorescence resonance-energy transfer; LBD; liga

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Acetylation-mediated epigenetic regulation of glucocorticoid receptor activity: Circadian rhythm-associated alterations of glucocorticoid actions in target tissues

Keywords: دامنه اتصال لیگاند; ACTH; adrenocorticotropic hormone; Dbp; albumin gene D site-binding protein; AMPK; AMP-activated protein kinase; AR; androgen receptor; AVP; arginine vasopressin; bHLH; basic helix-loop-helix; Bmal1; brain-muscle-arnt-like protein 1; CNS; central nervous

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Steroidogenic factor-1 (SF-1, NR5A1) and human disease

Keywords: دامنه اتصال لیگاند; ACT; adrenocortical tumor; AMH; anti-Müllerian hormone (also known as Müllerian-inhibiting substance); DBD; DNA-binding domain; DSD; disorders of sex development; LBD; ligand-binding domain; POI; primary ovarian insufficiency; Steroidogenic factor-1 (SF

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer

Keywords: دامنه اتصال لیگاند; GT3; R-γ-tocotrienol; 15-LOX-2; 15-lipoxygenase-2; 15-S-HETE; 15-S-hydroxyeicosatetraenoic acid; NF-κB; nuclear factor κB; TGFβ; transforming growth factor β; TAK-1; TGFβ-activating kinase-1; TAB-1; TGFβ-activating kinase-1 subunit; AT; RRR-α-toco

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

Keywords: دامنه اتصال لیگاند; GluA2; Ligand-binding domain; Agonist; Antagonist; Positive allosteric modulator; Crystal structure

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs

Keywords: دامنه اتصال لیگاند; Androgen receptor; Crystallization; Ligand-binding domain; DNA-binding domain; Androgen response elements;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Protective effect of ligand-binding domain of fibronectin-binding protein on mastitis induced by Staphylococcus aureus in mice

Keywords: دامنه اتصال لیگاند; Staphylococcus aureus (S. aureus); Ligand-binding domain; Mastitis; Inactivated vaccine

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine

Keywords: دامنه اتصال لیگاند; Glutamate receptor; Marine natural product; Synthetic; Radioligand binding; Electrophysiology; Ligand-binding domain;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Regulation of AMPA receptors and synaptic plasticity

Keywords: دامنه اتصال لیگاند; long-term potentiation; long-term depression; glutamate; receptor trafficking; receptor phosphorylation; ABP; AMPA receptor-binding protein; AMPAR; AMPA receptor; Arc; activity-regulated cytoskeleton-associated protein; Aβ; beta-amyloid; BAR; Bin/amphyph

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2009 سفارش ترجمه

Expression and purification of the ligand-binding domain of peroxisome proliferator-activated receptor alpha (PPARα)

Keywords: دامنه اتصال لیگاند; PPARα; Ligand-binding domain; Purification; Mass spectrometry

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Model of the extracellular domain of the human α7 nAChR based on the crystal structure of the mouse α1 nAChR extracellular domain

Keywords: دامنه اتصال لیگاند; nAChR, nicotinic acetylcholine receptor; ECD, extracellular domain; ACh, acetylcholineα7 nAChR; α1 nAChR; Homology model; Structure; Extracellular domain; Ligand-binding domain; Rational drug design

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Modulation of αCaMKII signaling by rapid ERα action

Keywords: دامنه اتصال لیگاند; ER; estrogen receptor; E2; 17β-estradiol; ERE; estrogen response element; LBD; ligand-binding domain; T; tamoxifen; PPT; propyl pyrazole triol; DPN; diarylpropionitrile; Rapid estrogen action; Estrogen receptor; Ca2+/calmodulin-dependent protein kinase I

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2008 سفارش ترجمه

Interactions between α-conotoxin MI and the Torpedo marmorata receptor α-δ interface

Keywords: دامنه اتصال لیگاند; α-CnTx; α-conotoxin; DMSO; dimethylsulfoxide; MALDI-TOF-MS; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; MS; mass spectrometry; NHS-ASA; N-hydroxysuccinimidyl-4-azido salicilyc acid; LBD; ligand-binding domain; nAChR; ni

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Recombinant Human PPAR-β/δ Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids

Keywords: دامنه اتصال لیگاند; crystal structure; fatty acid; ligand-binding domain; mass spectrometry; nuclear receptorPPAR, peroxisome proliferator-activated receptor; LBD, ligand-binding domain; FA, fatty acid

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Identification of covalent attachment site of antiestrogenic estradiol 11β-derivatives on human estrogen receptor α ligand-binding domain

Keywords: دامنه اتصال لیگاند; ER; estrogen receptor; LBD; ligand-binding domain; GST; glutathione-S-transferase; E2; estradiol; OHT; 4-hydroxytamoxifen; 17BAME2; 17α-bromoacetamidomethylE2; 17BAPE2; 17α-bromoacetamidopropylE2; 11BAEOPE2; 11β-bromoacetamidoethoxyphenylE2; 11BAPOPE2;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Mass spectrometry identification of covalent attachment sites of two related estrogenic ligands on human estrogen receptor α

Keywords: دامنه اتصال لیگاند; ER; estrogen receptor; hERα and mERα; human and mouse ERαs; NR; nuclear receptor; LBD; ligand-binding domain; hLBD and mLBD; human and mouse ERα portions involving LBD and adjacent domain F; LBP; ligand-binding pocket; GST; glutathione-S-transferase;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Lessons learnt from structural studies of the oestrogen receptor

Keywords: دامنه اتصال لیگاند; receptor agonist; antagonist; protein structure; selective oestrogen receptor modulator; SERM; activation function 2; ligand-binding domain

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه

Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor β gene (P453T)

Keywords: دامنه اتصال لیگاند; AUC; area under the curve; BMR; basal metabolic rate; CK; creatine kinase; FT3I; free T3 index; FT4I; free T4 index; GCRC; General Clinical Research Center; GRTH; generalized resistance to thyroid hormone; L-T3; liothyronine or L-3,3′, 5-triiodothyronin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease

Keywords: دامنه اتصال لیگاند; Nurr1; Transcriptional factor; Dopaminergic neuron; Parkinson's disease; Polymorphisms; AADC; l-aromatic amino acid decarboxylase; ADH2; retinoid acid converting enzyme; AF1; N-terminal region; BDNF; brain-derived neurotrophic factor; CRE; cAMP-response e

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

The conserved residue Phe273(282) of PPARα(γ), beyond the ligand-binding site, functions in binding affinity through solvation effect

Keywords: دامنه اتصال لیگاند; Peroxisome proliferator-activated receptor (PPAR); Mutation; Ligand-binding affinity; Solvation effect; Molecular dynamics; Surface plamon resonance (SPR); Transcriptional activation; PPAR; peroxisome proliferator-activated receptor; KD; equilibrium disso

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه