کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9435099 | 1615413 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
DBDRARγADH2N-terminal regionsubstantial nigral-aromatic amino acid decarboxylaseAF1VMAT2Tgf-αpTHVTANurr1GDNFDATAADCCRECRFFGFLBDBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Dopamine transporter - انتقال دهنده دوپامینParkinson's disease - بیماری پارکینسونtransforming growth factor-α - تبدیل فاکتور رشد αtyrosine hydroxylase - تیروزین هیدروکسیلازDNA binding domain - دامنه اتصال DNAligand-binding domain - دامنه اتصال لیگاندCNS - دستگاه عصبی مرکزیEmbryonic stem cells - سلولهای بنیادی جنینیcentral nervous system - سیستم عصبی مرکزیNBRE - شمارهTranscriptional factor - عامل رونویسیMARK - علامتcAMP-response element - عنصر پاسخ cAMPfibroblast growth factor - فاکتور رشد فیبروبلاستBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزvesicular monoamine transporter 2 - مونوآمین حامل 2ventral tegmental area - ناحیه تگمنتوم شکمیDopaminergic neuron - نورون دوپامینرژیکparathyroid hormone - هورمون پاراتیروئیدmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenPolymorphisms - پلی مورفیسمRetinoic acid receptor - گیرنده اسید رتینوئیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease](/preview/png/9435099.png)
چکیده انگلیسی
Nurr1, a transcription factor belonging to the orphan nuclear receptor superfamily, is critical in the development and maintenance of the dopaminergic system and as such it may have role in the pathogenesis of Parkinson' disease (PD). Human Nurr1 gene has been mapped to chromosome 2q22-23 and Nurr1 protein is predominantly expressed in central dopaminergic neurons. Nurr1 interacts with other factors critical for the survival of mensencephalic dopaminergic neurons and it appears to regulate the expression of tyrosine hydroxylase (TH), dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2), and l-aromatic amino acid decarboxylase (AADC), all of which are important in the synthesis and storage of dopamine. Experimental studies in Nurr1 knock-out mice indicate that Nurr1 deficiency results in impaired dopaminergic function and increased vulnerability of those midbrain dopaminergic neurons that degenerate in PD. Decreased Nurr1 expression is found in the autopsied PD midbrains, particularly in neurons containing Lewy bodies, as well as in peripheral lymphocytes of patients with parkinsonian disorders. Several variants in Nurr1 gene have been reported in association with PD. All these studies suggest that Nurr1 is not only essential in the development of mensencephalic dopaminergic neurons and maintenance of their functions, but it may also play a role in the pathogenesis of PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 77, Issues 1â2, SeptemberâOctober 2005, Pages 128-138
Journal: Progress in Neurobiology - Volume 77, Issues 1â2, SeptemberâOctober 2005, Pages 128-138
نویسندگان
J. Jankovic, S. Chen, W.D. Le,