Keywords: LOH، از دست دادن هتروزیگوتیسم; LOH, loss of heterozygosity; Oral dysplasia; Potentially malignant oral disorders; 3p; 9p; Oral cancer;
مقالات ISI LOH، از دست دادن هتروزیگوتیسم (ترجمه نشده)
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Keywords: LOH، از دست دادن هتروزیگوتیسم; 18-FDG PET, 18-fluodeoxyglucose positron emission tomography; 99-Tc-HDP, Technetium 99 m-hydroxymethylene diphosphonate; CT, computed tomography; FNLCC, Fédération Nationale des Centres de Lutte Contre le Cancer; LOH, loss of heterozygosity; MRI, magnetic
Keywords: LOH، از دست دادن هتروزیگوتیسم; HNSCC, head and neck squamous cell carcinoma; OSCC, Oral squamous cell carcinoma; LOH, Loss of heterozygosity; CSC, Cancer stem cells; CIS, Carcinoma insitu; SPT, second primary tumor; TAC, Transient Amplifying Cells; ALDH1, Aldehyde dehydrogenase1; EMT,
Keywords: LOH، از دست دادن هتروزیگوتیسم; AML, angiomyolipoma; LAM, lymphangioleiomyomatosis; LOH, loss of heterozygosity; mTOR, mammalian target of rapamycin; NIH, National Institutes of Health; PCR, polymerase chain reaction; TSC, tuberous sclerosis complex
Keywords: LOH، از دست دادن هتروزیگوتیسم; COG, Children's Oncology Group; FH, favorable histology; IMS, imaging mass spectrometry; KWT, Kenyan Wilms tumor; LC-MS/MS, liquid chromatography mass spectrometry; LOH, loss of heterozygosity; MALDI-TOF, matrix-assisted laser desorption ionization time o
Keywords: LOH، از دست دادن هتروزیگوتیسم; BE, Barrett's esophagus; EAC, esophageal adenocarcinoma; cfDNA, circulating free DNA; FFPE, formalin fixed paraffin embedded; LOH, loss of heterozygosity; LGD, low-grade dysplasia; HGD, high-grade dysplasia; chr., chromosome
Adrenal Medullary Hyperplasia Is a Precursor Lesion for Pheochromocytoma in MEN2 Syndrome 12
Keywords: LOH، از دست دادن هتروزیگوتیسم; AMH, adrenal medullary hyperplasia; LOH, loss of heterozygosity; MEN2, multiple endocrine neoplasia type 2; PCC, pheochromocytoma; RET, rearranged during transfection proto-oncogeneAdrenal medullary hyperplasia; MEN2; molecular alterations; loss; pheochro
Elucidation of Distinctive Genomic DNA Structures in Patients with 46,XX Testicular Disorders of Sex Development Using Genome Wide Analyses
Keywords: LOH، از دست دادن هتروزیگوتیسم; comparative genomic hybridization; disorders of sex development; sex differentiation; testisCGH, comparative genomic hybridization; CN, copy number; CNV, copy number variation; DSD, disorders of sex development; LOH, loss of heterozygosity; PCR, polymeras
Performance characteristics of molecular (DNA) analysis for the diagnosis of mucinous pancreatic cysts
Keywords: LOH، از دست دادن هتروزیگوتیسم; CCD, carcinoembryonic antigen/cytology diagnosis; CEA, carcinoembryonic antigen; EUS-FNA, EUS-guided FNA; HGD, high-grade dysplasia; IPMN, intraductal papillary mucinous neoplasm; LGD, low-grade dysplasia; LOH, loss of heterozygosity; MCN, mucinous cystic
Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors
Keywords: LOH، از دست دادن هتروزیگوتیسم; PGL, Hereditary paraganglioma; PHEO, Pheochromocytoma; SDHAF2, succinate dehydrogenase complex assembly factor 2; CTCF, CCCTC-binding factor (zinc finger protein); LOH, Loss of heterozygosity; Linc RNA, large intergenic non-coding RNA; UPGL, Untranslated
Decrease of PDSS2 expression, a novel tumor suppressor, in non-small cell lung cancer
Keywords: LOH، از دست دادن هتروزیگوتیسم; PDSS2, prenyl diphosphate synthase subunit 2; LOH, loss of heterozygosity; CoQ10, coenzyme Q10; EGFR, epithelial growth factor receptor; SCLC, small cell lung cancer; NSCLC, non-small cell lung cancerLung cancer; PDSS2; NSCLC; Tumor suppressor
Toward the Detection of Prostate Cancer in Urine: A Critical Analysis
Keywords: LOH، از دست دادن هتروزیگوتیسم; prostate; prostatic neoplasms; urine; biological markers; diagnostic techniques, urologicalAMACR, α-methylacyl coenzyme A racemase; ERG, ETS related gene; FDA, Food and Drug Administration; GSTP1, glutathione-S-transferase P 1; LOH, loss of heterozygosity
Somatic loss of heterozygosity, but not haploinsufficiency alone, leads to full-blown autoimmune lymphoproliferative syndrome in 1 of 12 family members with FAS start codon mutation
Keywords: LOH، از دست دادن هتروزیگوتیسم; ALPS, autoimmune lymphoproliferative syndrome; DN T cell, double-negative T cell; ICD, intracellular domain; ECD, extracellular domain; LOH, loss of heterozygosity; MNR, mutation-negative relative; MPR, mutation-positive relative; sFASL, soluble FAS ligan
Clinical and biological significance of Cdk10 in hepatocellular carcinoma
Keywords: LOH، از دست دادن هتروزیگوتیسم; HCC, Hepatocellular carcinoma; HBV, hepatitis B virus; HCV, hepatitis C virus; AFP, alpha fetoprotein; Cdk, Cyclin-dependent kinase; LOH, loss of heterozygosity; pCMV6-CDK10, Cdk10-expressing plasmid; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazol
Microarray analysis of responsible genes in increased growth rate in the subline of HL60 (HL60RG) cells
Keywords: LOH، از دست دادن هتروزیگوتیسم; M-FISH, multiplex fluorescence in situ hybridization; CGH, comparative genome hybridization; DM, double minute; HSR, homogenously staining region; LOH, loss of heterozygosity; SNP, single nucleotide polymorphism; UPD, uniparental disomyMicroarray analysis
Molecular epidemiology of adrenocortical tumors in southern Brazil
Keywords: LOH، از دست دادن هتروزیگوتیسم; ACC, adrenocortical carcinoma; ACT, adrenocortical tumors; LOH, loss of heterozygosity; CEDM, cisplatin, etoposide, doxorubicin, and mitotane; HPP, Hospital Pequeno Príncipe, BrazilTP53 mutation; Adrenocortical tumour; Arg337His
LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
Keywords: LOH، از دست دادن هتروزیگوتیسم; LTBP-2, latent transforming growth factor β binding protein 2; NPC, nasopharyngeal carcinoma; TGF-β, transforming growth factor β; TSG, tumor suppressor gene; LOH, loss of heterozygosity; VEGF, vascular endothelial growth factor; ECM, extracellular matrix
Mutations and epimutations in the origin of cancer
Keywords: LOH، از دست دادن هتروزیگوتیسم; ChIP, chromatin immunoprecipitation; CIN, chromosomal instability; CIMP, CpG island methylator phenotype; FAP, familial adenomatous polyposis; FCCX, familial colorectal cancer, type X; LINE, long interspersed element; LOH, loss of heterozygosity; LS, Lync
The human LIS1 is downregulated in hepatocellular carcinoma and plays a tumor suppressor function
Keywords: LOH، از دست دادن هتروزیگوتیسم; LIS1, human lissencephaly-1 gene; HCC, hepatocellular carcinoma; MDL, Miller–Dieker lissencephaly syndrome; LOH, loss of heterozygosity; RT-PCR, reverse transcription polymerase chain reaction; shRNA, short hairpin RNALIS1 gene; Reduced expression; HCC; C
New perspectives in hemiascomycetous yeast taxonomy
Keywords: LOH، از دست دادن هتروزیگوتیسم; Hemiascomycetous yeasts; Phylogeny; Evolution; Ribosomal DNA; Interspecific hybrid; SystematicsLevures; Phylogénie; Évolution; ADN ribosomique; Hybride inter-espèce; SystématiqueKOG, euKaryotic Orthologous Group; LOH, Loss of Heterozygosity; mtDNA, mitoch
Loss of 10q26.1–q26.3 in association with 7q34–q36.3 gain or 17q24.3–q25.3 gain predict poor outcome in pediatric medulloblastoma
Keywords: LOH، از دست دادن هتروزیگوتیسم; Medulloblastoma; CGH; Chromosomal imbalances; FISH; LOHMB, medulloblastoma; HRP-CGH, high resolution prometaphase comparative genomic hybridization; I-FISH, interphase fluorescent in situ hybridization; LOH, loss of heterozygosity; cnLOH, copy-neutral los
Coalterations of p53 and PTEN tumor suppressor genes in non–small cell lung carcinoma patients
Keywords: LOH، از دست دادن هتروزیگوتیسم; AP-PCR, arbitrarily primed polymerase chain reaction; CI, confidence interval; FAK, focal adhesion kinase; LOH, loss of heterozygosity; MSP, methylation-specific PCR; NSCLC, non–small cell lung carcinoma; PAA, polyacrylamide; PCR-SSCP, polymerase chain re
Loss of Heterozygosis on IFN-α Locus is a Prognostic Indicator of Bacillus Calmette-Guerin Response for Nonmuscle Invasive Bladder Cancer
Keywords: LOH، از دست دادن هتروزیگوتیسم; urinary bladder; carcinoma; Mycobacterium bovis; loss of heterozygosity; interferon-alphaBCG, bacillus Calmette-Guerin; IFN-α, interferon-α; IL, interleukin; LOH, loss of heterozygosity; NMIBC, nonmuscle invasive bladder cancer; TUR, transurethral resecti
Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India
Keywords: LOH، از دست دادن هتروزیگوتیسم; ESCC, esophageal squamous cell carcinoma; LOH, loss of heterozygosity; SNP, single nucleotide polymorphism; CGH, comparative genome hybridization; TMA, tissue microarrayGenomic alteration; Esophageal cancer; SNP array
Molecular features of thyroid oncocytic tumors
Keywords: LOH، از دست دادن هتروزیگوتیسم; WHO, World Health Organization; CGH, comparative genomic hybridization; LOH, loss of heterozygosity; FTC, follicular thyroid carcinoma; VHL, Von Hippel Lindau; TCO, Thyroid Tumor with Cell Oxyphilia; NMTCI, Non-Medullary Thyroid Carcinoma I; PTC, papillar
A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia
Keywords: LOH، از دست دادن هتروزیگوتیسم; PPAR, Peroxisome Proliferator-Activated Receptors; CRC, colorectal cancer; LOH, loss of heterozygosity; APC, adenomatous poliposis coliPeroxisome Proliferator-Activated Receptor; Loss-of-function mutation; Colorectal cancer; Dyslipidemia
History, Molecular Mechanisms, and Endoscopic Treatment of Barrett's Esophagus
Keywords: LOH، از دست دادن هتروزیگوتیسم; Gastroesophageal Reflux; Esophageal Neoplasms; Gene Expression RegulationBMP, bone morphogenetic protein; EMR, endoscopic mucosal resection; GERD, gastroesophageal reflux disease; LOH, loss of heterozygosity; PDT, photodynamic therapy; RFA, radiofrequency
Pancreatic endocrine tumor EUS-guided FNA DNA microsatellite loss and mortality
Keywords: LOH، از دست دادن هتروزیگوتیسم; EUS-FNA, EUS-guided FNA; FAL, fractional allelic loss; IQR, interquartile range; LOH, loss of heterozygosity; PET, pancreatic endocrine tumor
Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration
Keywords: LOH، از دست دادن هتروزیگوتیسم; DLC1, deleted in liver cancer 1; GAP, GTPase activating protein; GEF, guanine nucleotide exchange factor; LOH, loss of heterozygosity; PI3K, phosphatidylinositol 3-kinase; PIP3, phosphatidylinositol 3,4,5-trisphosphate; PTEN, phosphatase and tensin homolo
Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1
Keywords: LOH، از دست دادن هتروزیگوتیسم; BRCT, BRCA1 COOH terminal domain; DBD, DNA-binding domain; DCIS, ductal carcinoma in situ; ESE, exonic splicing enhancer; LOH, loss of heterozygosity; ONPG, o-nitrophenyl-β-d-galactopyranoside; SD, synthetic drop-out medium; WT, wild typeBRCA1; Breast can
Frequent Inactivation of Axon Guidance Molecule RGMA in Human Colon Cancer Through Genetic and Epigenetic Mechanisms
Keywords: LOH، از دست دادن هتروزیگوتیسم; 5aza-dC, 5-aza-2′-deoxycytidine; BMP, bone morphogenetic protein; bp, base pair; CPT, camptothecin; CRC, colorectal cancer; DAPI, 4′,6-diamidino-2-phenylindole; DCC, deleted-in-colorectal cancer; LOH, loss of heterozygosity; MSP, methylation-specific poly
Quantification of Epigenetic and Genetic 2nd Hits in CDH1 During Hereditary Diffuse Gastric Cancer Syndrome Progression
Keywords: LOH، از دست دادن هتروزیگوتیسم; HDAC, histone deacetylase; HDGC, hereditary diffuse gastric cancer; IHC, immunohistochemistry; LOH, loss of heterozygosity; PCR, polymerase chain reaction
Mouse Models of Colon Cancer
Keywords: LOH، از دست دادن هتروزیگوتیسم; COX, cyclooxygenase; FAP, familial adenomatous polyposis; HNPCC, hereditary nonpolyposis colon cancer; IDL, insertion/deletion mutation; IL, interleukin; LOH, loss of heterozygosity; MMR, mismatch repair; MNNG, N-methyl-N′-nitro-N-nitrosoguanidine; MSI, m
Nitropolycyclic aromatic hydrocarbons are inducers of mitotic homologous recombination in the wing-spot test of Drosophila melanogaster
Keywords: LOH، از دست دادن هتروزیگوتیسم; 1,5DNN, 1,5-dinitronaphthalene; HR, homologous recombination; LOH, loss of heterozygosity; 9NA, 9-nitroanthracene; 2NF, 2-nitrofluorene; 1NN, 1-nitronaphthalene; NPAHs, nitropolycyclic aromatic hydrocarbons; PAHs, polycyclic aromatic hydrocarbons; SCEs, s
Frequent inactivation of RUNX3 in endometrial carcinoma
Keywords: LOH، از دست دادن هتروزیگوتیسم; LOH, loss of heterozygosity; MS-PCR, methylation-specific PCR; RT-PCR, reverse-transcription PCRRUNX3; Promoter hypermethylation; Endometrial carcinoma; Loss of heterozygosity
Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer
Keywords: LOH، از دست دادن هتروزیگوتیسم; HDAC, histone deacetylase; LOH, loss of heterozygosity; NSCLC, non-small cell lung cancers; TGS, tumor suppressor geneChromosome 15; LOH; Lung cancer; SIN3A
Visualizing loss of heterozygosity in living mouse cells and tissues
Keywords: LOH، از دست دادن هتروزیگوتیسم; LOH, loss of heterozygosity; ES, embryonic stem; YFP, yellow fluorescence protein; shRNA, short hairpin RNA; FACS, Fluorescence Activated Cell Sorting; UPD, uniparental disomy; GFP, green fluorescent protein; CFP, cyan fluorescent proteinLoss of heterozyg
Minimal deletion regions in lung squamous cell carcinoma: Association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers
Keywords: LOH، از دست دادن هتروزیگوتیسم; NSCLC, non-small cell lung cancer; SCC, lung squamous cell carcinoma; FAL, high fractional allelic loss; DSB, double-strand break; TSG, tumor suppressor genes; MDRs, minimal deletion regions; LOH, loss of heterozygosity; RT-PCR, reverse transcriptase-poly
Allelic loss and mutations in a new ETRG-1 gene are early events in diethylstilbestrol-induced renal carcinogenesis in Syrian hamsters
Keywords: LOH، از دست دادن هتروزیگوتیسم; BLAST, basic local alignment search tool; cDNA, DNA complementary to RNA; DES, diethylstilbestrol; DNase, Deoxyribonuclease; dNTP, deoxyribonucleoside triphosphate; ETRG-1, Estrogen Target Rodent Gene-1; LOH, loss of heterozygosity; ORF, open reading fram
Genomic instability, mutations and expression analysis of the tumour suppressor genes p14ARF, p15INK4b, p16INK4a and p53 in actinic keratosis
Keywords: LOH، از دست دادن هتروزیگوتیسم; SCC, squamous cell carcinoma; AK, actinic keratosis; BCC, basal cell carcinoma; NMSC, non-melanoma skin cancer; Rb, retinoblastoma; LOH, loss of heterozygosity; AI, allelic imbalance; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MSI, microsatellite in
Promoter methylation, mutation, and genomic deletion are involved in the decreased NDRG2 expression levels in several cancer cell lines
Keywords: LOH، از دست دادن هتروزیگوتیسم; NDRG, N-Myc downstream-regulated gene; PCR–SSCP, single strand conformation polymorphism analysis of polymerase chain reaction production; BCA, bicinchoninic acid; FBS, fetal bovine serum; LOH, loss of heterozygosity; TSG, tumor suppressor geneNDRG2; Loss
Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma
Keywords: LOH، از دست دادن هتروزیگوتیسم; GBC, gallbladder carcinoma; MSP, methylation-specific PCR; TSG, tumor suppressor genes; LOH, loss of heterozygosity; COBRA, combined restriction analysisMethylation; Tumor suppressor genes; Gallbladder carcinoma
Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice
Keywords: LOH، از دست دادن هتروزیگوتیسم; HDAC, histone deacetylase; LOH, loss of heterozygosity; NIC, active intracellular Notch; PB, peripheral blood; T-ALL, T-cell acute lymphoid leukemia; TCR, T-cell receptorT-cell lymphoma; Plastic; Ikaros; Notch; Hematopoiesis; Chromatin remodeling; Genome
Disruption of transforming growth factor β-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4
Keywords: LOH، از دست دادن هتروزیگوتیسم; SMAD2; SMAD4; HNSCC; Genetic mutation; TGF-β receptorsTGFβ, Transforming growth factor-β; HNSCC, head and neck squamous cell carcinoma; TGFBRI, TGF-β type I receptor; TGFBRII, TGF-β type II receptor; LOH, loss of heterozygosity; ACVRIB, activin receptor t
Epigenetic and Genetic Alterations in Netrin-1 Receptors UNC5C and DCC in Human Colon Cancer
Keywords: LOH، از دست دادن هتروزیگوتیسم; AP, adenomatous polyps; CIMP, CpG island methylator phenotype; CNM, corresponding normal mucosa; COBRA, combined bisulfite restriction assay; CRC, colorectal cancer; LOH, loss of heterozygosity; MSI, microsatellite instability; NTN1, Netrin-1; RT-PCR, rev
Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation
Keywords: LOH، از دست دادن هتروزیگوتیسم; KLF6, Kruppel like factor 6; HCC, hepatocellular carcinoma; HBV, hepatitis B virus; HCV, hepatitis C virus; LOH, loss of heterozygosity; wtKLF6, wildtype KLF6; SV1, splice variant 1Hepatocellular carcinoma; Alternative splicing; KLF6SV1; Dysplasia; E-cadh
Evolution of cancer stem cells
Keywords: LOH، از دست دادن هتروزیگوتیسم; CSCs, cancer stem cells; TA, transiently amplifying precursors; LOH, loss of heterozygosity; LOI, loss of imprinting; EZH2, enhancer of Zeste homolog 2; hTERT, human telomerase reverse transcriptase; mtDNA, mitochondrial genome; ROS, reactive oxygen speci
Frequent Alteration of XAF1 in Human Colorectal Cancers: Implication for Tumor Cell Resistance to Apoptotic Stresses
Keywords: LOH، از دست دادن هتروزیگوتیسم; CpG, CG dinucleotide; 5-FU, 5-fluorouracil; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GFP, green fluorescent protein; IAP, inhibitor of apoptosis protein; IFN, interferon; LOH, loss of heterozygosity; PARP, poly ADP ribose polymerase; RNase, ribonu
Towards the analysis of the genomes of single cells: Further characterisation of the multiple displacement amplification
Keywords: LOH، از دست دادن هتروزیگوتیسم; CGH, Comparative Genomic Hybridisation; DOP, Degenerate-Oligonucleotide-Primed PCR; EM, Electron Microscopy; LOH, Loss of Heterozygosity; MDA, Multiple Displacement Amplification; MW, Molecular Weight; ORF, Open Reading Frame; PEP, Primer Extension Preamp
Elevated Microsatellite Instability at Selected Tetranucleotide Repeats does not Correlate with Clinicopathologic Features of Bladder Cancer
Keywords: LOH، از دست دادن هتروزیگوتیسم; BC, bladder cancer; LOH, Loss of Heterozygosity; MSI, microsatellite instability; MDMSI, mono- and dinucleotide repeat MSI; EMAST, elevated microsatellite alterations at selected tetranucleotide repeats; IHC, immunohistochemistry; MMR, mismatch repair; RF