
A novel mechanism for LQT3 with 2:1 block: A pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation
Keywords: Cardiac Sodium Channel; LQT3; V411M; Flecainide; Mexiletine; Lidocaine; WT; wild-type; LQTS; Long QT Syndrome; AP; action potential; ECG; electrocardiogram; GOF; gain of function; HEK; human embryonic kidney; TdP; torsades de pointes;