Keywords: Anthocyanins; Cholesterol; Sterol; Hypercholesterolemia; ABCG5 and 8; ATP binding cassette transporter 5 and 8; ACAT2; acyl CoA:cholesterol acyltransferase2; CYP7A1; cholesterol-7α-hydroxylase; CrA; cranberry anthocyanins; HMG-CoA-R; 3-Hydroxy-3-methylgl
مقالات ISI (ترجمه نشده)
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Keywords: B2M; beta-2-microglobulin; BMI; body mass index; CCL; chemokine (C-C motif) ligand; cDNA; complimentary deoxyribonucleic acid; CXCL16; chemokine (C-X-C motif) ligand 16; DPP4; dipeptidyl-peptidase 4; DXA; dual energy X-ray absorptiometry; g; gravity; Gadd
Keywords: PTX3; Pentraxin 3; CV; cardiovascular; TNF; tumor necrosis factor; IL; interleukin; CRP; C-reactive protein; HDL-c; high-density lipoprotein cholesterol; SAP; serum amyloid P component; NF-κB; nuclear factor kappa B; ECs; endothelial cells; SMCs; smooth
Keywords: Multi-target drug design; Steered molecular dynamics; Alzheimer's disease; Amyloid beta peptide; β-secretase; PPARγ; LXRα;
Keywords: Non-alcoholic fatty liver; Lipogenesis; Lipid secretion; Homocysteine; Sulfur-containing amino acid metabolism; ACC; acetyl-CoA carboxylase; AMPK; adenosine monophosphate-activated protein kinase; ApoB; apolipoprotein B; BHMT; betaine-homocysteine methy
Keywords: TUNEL; terminal deoxynucleotidyl transferase dUTP nick-end labeling; ELISA; enzyme-linked immunosorbent assay; DNA; deoxyribonucleic acid; TNFα; tumor necrosis factor-alpha; Foxa2; forkhead box protein A2; HNF6; hepatocyte nuclear factor 6; C/EBPα; CCAA
Keywords: Fatty liver; Bile acid; Cholesterol; H2S; LXRα;
Keywords: ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: PR; progesterone receptor; PIC; pro-inflammatory cytokines; P4; progesterone; Erk; extracellular-signal-regulated kinase 1/2; p53; protein 53; AKT; protein kinase B; TRAF2; tumor necrosis factor receptor-associated factor 2; PR-KO; PR knockout; Mif; mifep
Keywords: 5,6-Epoxy-cholesterol; Cholesterol oxide; Cholesterol epoxide; Dendrogenin; Cancer; AEBS; antiestrogen binding site; ChEH; cholesterol epoxide hydrolase; Tam, tamoxifen; trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; D8D7I; 3β-hydrox
Keywords: AEBS; antiestrogen binding site; ChEH; cholesterol epoxide hydrolase; Tam; tamoxifen, trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; 4OH-tam; 4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenylbut-1-enyl]phenol; Ralox; raloxifene, [
O-GlcNAc site-mapping of liver X receptor-α and O-GlcNAc transferase
Keywords: LXRα; O-GlcNAc; OGT; HCD MS; ETD MS;
C1q tumor necrosis factor-related protein 9 in atherosclerosis: Mechanistic insights and therapeutic potential
Keywords: CTRP9; AdipoR1; N-cadherin; Atherosclerosis; Adiponectin; CVD; cardiovascular disease; CTRPs; C1q tumor necrosis factor-related proteins; AMI; acute myocardial infarction; HMW; high molecular weight; AMPK; adenosine monophosphate-activated protein kinase;
Impact of capsaicin, an active component of chili pepper, on pathogenic chlamydial growth (Chlamydia trachomatis and Chlamydia pneumoniae) in immortal human epithelial HeLa cells
Keywords: Chlamydia trachomatis; Capsaicin; HeLa cells; TRPV1; PPARγ; LXRα;
MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis
Keywords: ApoB; apolipoprotein B; CBDL; common bile duct ligation; CCl4; carbon tetrachloride; CPT1; peroxisome carnitine palmitoyl transferase 1; CREBH; cAMP responsive element binding protein H; DNL; de novo lipogenesis; ECM; extracellular matrix; ER; endoplasmic
Curcumin enhances LXRα in an AMP-activated protein kinase-dependent manner in human macrophages
Keywords: LXR; liver X receptor; ABCA1; ATP-binding cassette transporter A1; ABCG1; ATP-binding cassette transporter G1; SREBP1c; sterol response element binding protein 1c; AMPK; AMP-activated protein kinase; PMA; phorbol myristate acetate; fMLP; formyl-Met-Leu-Ph
Chemistry, biochemistry, metabolic fate and mechanism of action of 6-oxo-cholestan-3β,5α-diol (OCDO), a tumor promoter and cholesterol metabolite
Keywords: Cholesterol; Oxysterol; Oncometabolism; Tumor promoter; Glucocorticoid receptor; Breast cancer; AEBS; antiestrogen binding site; ChEH; cholesterol epoxide hydrolase; Tam; Tamoxifen, trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; D8D7I
Maternal fructose induces gender-dependent changes in both LXRα promoter methylation and cholesterol metabolism in progeny
Keywords: RCT; Reverse cholesterol transport; LXRα; Liver X-receptor alpha; CpG islands; CG-dinucleotide-rich regions in the gene promoter; HDL; High-density lipoproteins; PPAR; Peroxisome proliferator-activated receptor; SRB-1; Scavenger Receptor class B, member
SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression
Keywords: SIRT1; LXRα; ABCA1; Cholesterol and lipid metabolism;
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Keywords: NASH; Nrf2; TBE-31; ACACA; acetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOT7; acetyl-CoA thioesterase 7; ACOX2; acetyl-CoA oxidase 2; ADRP; adipose differentiation-related protein; AP-1; activator protein 1; ApoB; apolipoprotein B; ATF4; activa
Inhibition of IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by glycyrrhizin via activating LXRα
Keywords: Glycyrrhizin; Human gingival fibroblasts; IL-8; NF-κB; LXRα;
Platycodin D suppressed LPS-induced inflammatory response by activating LXRα in LPS-stimulated primary bovine mammary epithelial cells
Keywords: Platycodin D; BMEC; LPS; LXRα; NF-κB;
Liver X receptors agonists suppress NLRP3 inflammasome activation
Keywords: LXRs; liver X receptors; LXRα; NR1H3; LXRβ; NR1H2; T0901317; T09; GW3965; GW; mtROS; mitochondria reactive oxygen species; NLRP3; the NLR family pyrin domain-containing protein 3; ASC; speck-like protein containing a caspase recruitment domain; PAMP; pa
16-Dehydropregnenolone lowers serum cholesterol by up-regulation of CYP7A1 in hyperlipidemic male hamsters
Keywords: 16-Dehydropregnenolone; Cholesterol; Bile acid; CYP7A1; LXRα; PPARα; HepG2;
NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition
Keywords: 1-25-diOH D; dihydroxyvitamine D; 25-OH D; 25-hydroxyvitamin D; APO; apolipoprotein; BMI; body mass index; ER; endoplasmic reticulum; FC; free cholesterol; FFAs; free fatty acids; FGF-2; fibroblast growth factor 2; FXRÉ; farnesoid X receptor α; HDL; hig
Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells
Keywords: Cholesterol biosynthesis inhibitors; FF-MAS; LXRα; Nuclear lipid droplets;
Acanthoic acid inhibits LPS-induced inflammatory response by activating LXRα in human umbilical vein endothelial cells
Keywords: Acanthoic acid; Human umbilical vein endothelial cells; Cytokine; NF-κB; LXRα;
Effects of platycodin D on IL-1β-induced inflammatory response in human osteoarthritis chondrocytes
Keywords: Platycodin D; Osteoarthritis chondrocyte; IL-1β; LXRα;
Comparison of liver microRNA transcriptomes of Tibetan and Yorkshire pigs by deep sequencing
Keywords: miRNA; microRNA; TPL; Tibetan pig liver; YKL; Yorkshire pig liver; qPCR; quantitative real-time PCR; Stem-loop qPCR; stem-loop quantitative real-time PCR; Sirt1; Sirtuin type 1; PKM2; M2 isoform of pyruvate kinase; LXRα; Liver X receptor α; SR-BI; s
Platelet-activating factor and hydrogen peroxide exert a dual modulatory effect on the transcription of LXRα and its target genes in human neutrophils
Keywords: LXRα; liver X receptor; PAF; platelet-activating factor; H2O2; hydrogen peroxide; ABCA1; ATP-binding cassette transporter A1; ABCG1; ATP-binding cassette transporter G1; SREBP1c; sterol regulatory element-binding protein 1c; NF-κB; nuclear factor κB; R
High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a High-Fat Fish-Oil Diet in C57BL/6 Mice
Keywords: ACC1; acetyl-CoA carboxylase-1; CPT1a; carnitine palmitoyltransferase 1a; ChREBP; carbohydrate response element binding protein; FASN; fatty acid synthase; FFA; free fatty acid; LPL; lipoprotein lipase; LXRα; liver-X-receptor; MTTP; microsomal triglyceri
Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1
Keywords: Cortisol; Cortisone; 11β-hydroxysteroid dehydrogenase 1; 11β-hydroxysteroid dehydrogenase 2; THP1 macrophages; Foam cells; EMR1; epidermal growth factor like module-containing mucin-like hormone receptor-like1; CD163; Cluster of Differentiation 163; MMR
miR-28-5p Involved in LXR-ABCA1 Pathway is Increased in the Plasma of Unstable Angina Patients
Keywords: miR-28-5p; Unstable angina; ABCA1; LXRα; Circulation;
Acanthoic acid ameliorates lipopolysaccharide-induced acute lung injury
Keywords: Acanthoic acid; LPS; Acute lung injury; NF-κB; LXRα;
Red bayberry extract prevents high-fat diet-induced metabolic disorders in C57BL/6 mice
Keywords: Red bayberry; Metabolic syndrome; High-fat diet; LXRα; PPARα; Myricitrin (PubChem CID: 5281673); Isoquercitrin (PubChem CID: 5280804); Quercitrin (PubChem CID: 5280459); Myricetin (PubChem CID: 5281672); Quercetin (PubChem CID: 5280343); Gallic acid (Pu
Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice
Keywords: PPARγ; peroxisome proliferator-activated receptor γ; LXRα; liver X receptor α; OB/OB; normal genetic background; ob/ob; obese genetic background; PparγWT; wild-type PPARγ; PparγÎH; hepatocyte-specific PPARγ knockout; Liver X receptor α; Peroxiso
22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder
Keywords: Cholesterosis; 22(R)-hydroxycholesterol; Pioglitazone; ABCA1; PPARγ; LXRα;
Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis
Keywords: ASXL; additional sex comb-like; LXRα; liver X receptor alpha; WB; Western blotting; Luc; luciferase; shRNA; small hairpin RNA; KD; knockdown; ChIP; chromatin immunoprecitation; HFD; high fat diet; Liver X receptor; ASXL1; ASXL2; Lipogenesis; Liver;
7-Ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages
Keywords: 7-Ketocholesteryl-9-carboxynonanoate; PPARγ; LXRα; ABCA1; Cholesterol efflux;
Adipose tissue and liver metabolic responses to different levels of dietary carbohydrates in gilthead sea bream (Sparus aurata)
Keywords: eF1α; elongation factor 1α; F; fiber; FAS; fatty acid synthase; FFA; free fatty acids; GK; glucokinase; G6Pase; glucose 6-phosphatase; G6PDH; glucose-6-phosphate dehydrogenase; HSI; hepatosomatic index; HSL; hormone sensitive lipase; L; lipids; LPL; lip
Identification of a novel partial agonist of liver X receptor α (LXRα) via screening
Keywords: ABC; ATP-binding cassette; ApoE; apolipoprotein E; DRIP205; vitamin D receptor-interacting protein 205; FAS; fatty acid synthase; GAPDH; glyceraldehyde-phosphate dehydrogenase; HDL; high-density lipoprotein; LBD; ligand-binding domain; LXR; liver X recept
Quercetin-3-O-glucuronide induces ABCA1 expression by LXRα activation in murine macrophages
Keywords: ABCA1; ATP-binding cassette, subfamily A, member 1; HDL; high density lipoprotein; HDLC; high density lipoprotein-cholesterol; LXRα; liver X receptor alpha; NNE; Nelumbo nucifera leaf extracts; Q3GA; quercetin-3-O-glucuronide; RCT; reverse cholesterol tr
Quercetin up-regulates expressions of peroxisome proliferator-activated receptor γ, liver X receptor α, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line
Keywords: ABCA1; ATP binding cassette transporter A1; apoA1; apolipoprotein A1; DMSO; dimethyl sulfoxide; HDL; high density lipoprotein; LDL; low-density lipoprotein; LXRα; liver X receptor α; mRNA; messenger RNA; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltet
Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice
Keywords: HFD; high-fat diet; FFA; free fatty acid; ALT; alanine aminotransferase; AST; aspartate aminostransferase; AdipoR1; adiponectin receptor-1; AdipoR2; adiponectin receptor-2; AMPK; AMP-activated protein kinase; CPT1; carnitine palmitoyltransferase 1; CD36;
HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes
Keywords: CBS; C/EBPα binding site; C/EBPs; CCAAT/enhancer binding proteins; ChIP; chromatin immunoprecipitation assay; Co-IP; co-immunoprecipitation; CYP7A1; cholesterol 7α-hydroxylase; FAS; fatty acid synthase; HDAC; histone deacetylase; HFD-MetS; high-fat-diet
Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation
Keywords: LDL; low-density lipoprotein; DPPH; 1,1-Diphenyl-2-picrylhydrazyl; TBARS; thiobarbituric acid reactive substances; REM; relative electrophoretic mobility; ox-LDL; oxidized LDL; acLDL; acetylated LDL; SR-As; class A scavenge receptors; PPARs; peroxisome pr
Panax notoginseng saponins attenuate atherosclerosis via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression
Keywords: AS; atherosclerosis; PNS; Panax notoginseng saponins; LXRα; liver X receptor α; ABCA1; ATP-binding cassette transporter A1; ABCG1; ATP-binding cassette transporter G1; NF-κB; nuclear factor-kappa B; IL-6; Interleukin 6; MCP-1; macrophage chemoattractan
Piperine, an LXRα antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat diet
Keywords: AMPK; AMP-activated protein kinase; LXRα; liver X receptor α; CD36; CD36 antigen; SREBP1c; sterol regulatory element binding protein 1c; ChREBPα; carbohydrate response element binding protein α; ER; endoplasmic reticulum; HFD; high fat diet; BIP; bind
Platelet lysate suppresses the expression of lipocalin-type prostaglandin D2 synthase that positively controls adipogenic differentiation of human mesenchymal stromal cells
Keywords: L-PGDS; Lipocalin-type prostaglandin D2 synthase; MSCs; Mesenchymal stromal cells; PL; Platelet lysate; FCS; Fetal calf serum; PPARγ; Peroxisome proliferator-activated receptor gamma; CEBPα; CCAAT/enhancer binding protein alpha; FABP4; Fatty acid bindin