کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5508288 1537693 2017 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition
چکیده انگلیسی
41 genes in gene cluster 1 and 14 genes in cluster 2 were significantly differentially methylated in dependency of NAFLD and hepatic fibrosis. We detect new genes significantly changed in methylation, including APO family members (lipid transport), NPC1L1, STARD (cholesterol transport) and GRHL (energy homeostasis). Our results allow novel insights into the hepatic epigenetic regulation of genes important for lipid and vitamin D balance in NAFLD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1862, Issue 3, March 2017, Pages 314-323
نویسندگان
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