The ERK and PI3K signaling pathways mediate inhibition of insulin-like growth factor-1 receptor mRNA expression by somatostatin
Keywords: Akt; MAPK; U0126; LY294002; Rainbow trout
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A novel diffusion cell model for the in vitro assessment of transcutaneous breast cancer therapeutics: Effect of permeants on MCF-7 cells cultured within the receptor compartment
Keywords: Breast cancer; Topical drug delivery; 4-Hydroxytamoxifen; EGFR inhibitors; PD98059; LY294002; Eicosapentaenoic acid; Cyclopore track etched membrane; Franz diffusion cell; Skin; Composite model
MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: Synergistic action with LY294002, an inhibitor of phosphatidylinositol 3′-kinase
Keywords: MK591; 5-Lipoxygenase; LY294002; Apoptosis
Participation of the phosphatidylinositol 3-kinase/Akt pathway in Junín virus replication in vitro
Keywords: Junín virus; Phosphatidylinositol 3-kinase; Akt; Ly294002; Argentine hemorrhagic fever
LPS-stimulated MUC5AC production involves Rac1-dependent MMP-9 secretion and activation in NCI-H292 cells
Keywords: AG; AG1478; DPI; diphenyleneiodonium; EGFR; epidermal growth factor receptor; GM; GM6001; LPS; lipopolysaccharides; LY; LY294002; MMP; matrix metalloproteinase; MUC5AC; mucin 5AC; NAC; N-acetylcysteine; NADPH; nicotinamide adenine dinucleotide phosphate;
Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K–PDK1 signaling
Keywords: PKB/Akt, protein kinase B; FCS, fetal calf serum; HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid; LY294002, PI3K inhibitor; PI3K, phosphatidylinositol 3-kinaseK+ channel; Cell membrane potential; PI3K; LY294002
Macrophage inflammatory protein-1β induced cell adhesion with increased intracellular reactive oxygen species
Keywords: AngII; angiotensin II; CAMs; cell adhesion molecules; CVD; cardiovascular disease; DCFHDA; 2â²7â²-dichlorofluorescein-diacetate; DPI; diphenyleneiodonium; ECs; endothelial cells; FBS; fetal bovine serum; GTP; guanosine triphosphate; HIV; human immunodef
Cell migration and activated PI3K/AKT-directed elongation in the developing rat Müllerian duct
Keywords: Müllerian duct; Cell migration; Duct elongation; PI3K/AKT pathway; LY294002; Phosphorylated AKT; Wolffian duct; Coelomic epithelium; Tubulerization
LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway
Keywords: LY294002; Egr-1; Leukemia; Invasion; PI3K
Detailed molecular analysis of the induction of the L-PK gene by glucose
Keywords: L-type pyruvate kinase; LY294002; LY303511; Insulin-independent; Glucose signaling; Hepatocytes; Chromatin immunoprecipitation; Gene promoter
Radiosensitization of cervical cancer cells via double-strand DNA break repair inhibition
Keywords: LY294002; PI3K; H2AX; Cervical cancer; DSB; HeLa; DNA-PK
Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation
Keywords: Hypoxia; Akt; Erk; PD98059; LY294002; SDF-1; CXCR4; Transmigration; HL-60
Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells
Keywords: Mouse ES cells; Cell cycle; PI3 kinase; LY294002; Serum withdrawal;
Activation of Telomerase by Ionizing Radiation: Differential Response to the Inhibition of DNA Double-Strand Break Repair by Abrogation of Poly(ADP-ribosyl)ation, by LY294002, or by Wortmannin
Keywords: Telomerase; Irradiation; Double-strand breaks; LY294002; Wortmannin;
Inhibition of phosphatidylinositol 3-kinase causes cell death in rat osteoblasts through inactivation of Akt
Keywords: Osteoblasts; LY294002; PI3-kinase/Akt pathway
Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k–Akt signaling pathway
Keywords: Notch intracellular domain; RBP-Jk; Zinc; Phosphatidylinositol 3-kinase; Akt; Cytoplasmic retention; Wortmannin; LY294002
Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-β1–stimulated primary human fibroblasts
Keywords: TIMP-1; real-time PCR; Smad; dominant negative Smad-2; -3; PI3K-Akt; LY294002; MEK-ERK; U0126DN, Dominant-negative; ERK, Extracellular signal-regulated kinase; MAPK, Mitogen-activated protein kinase; MEK, Mitogen-activated protein kinase kinase; MMP, Matr
Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor
Keywords: MDCK; pIgR; Transcytosis; Retromer; Vps35; Sorting-nexin; Phosphoinositide; Phosphatidylinositol; LY294002; Receptor
PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells
Keywords: Endoplasmic reticulum stress; PI3K-Akt pathway; LY294002; Wortmannin; PD98059; CHOP
Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner
Keywords: PI3 kinase/Akt pathway; LY294002; Doxorubicin; Apoptosis; Combination therapy; p53
PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation
Keywords: Extracellular signal-regulated kinase 1 and 2; Phosphatidylinositol 3-kinase; Insulin; Epidermal growth factor; Ras; Akt; Wortmannin; LY294002; Protein kinase C; Phorbol 12-myristate 13-acetate
LY294002 inhibits LPS-induced NO production through a inhibition of NF-κB activation: independent mechanism of phosphatidylinositol 3-kinase
Keywords: Nitric oxide (NO); Inducible nitric oxide synthase (iNOS); LY294002; Phosphatidylinositol 3-kinase (PI3K); NF-κB; Lipoploysaccharide;
Involvement of extracellular signal-regulated kinases 1/2 and (phosphoinositide 3-kinase)/Akt signal pathways in acquired resistance against neurotoxin of 6-hydroxydopamine in SH-SY5Y cells following cell-cell interaction with astrocytes
Keywords: signal pathways; neuroblastoma; neuroprotection; CREB; cAMP response element binding protein; ERK1/2; extracellular signal-regulated kinases 1 and 2; FBS; fetal bovine serum; LDH; lactate dehydrogenase; LY294002; 2-(4-morpholino)-8-phenyl-4H-1-benzopyran-
Co-induction of cell death and survival pathways by phosphoinositide 3-kinase
Keywords: PI3K; phosphoinositide 3-kinase; SW; serum withdrawal; ROS; reactive oxygen species; SAPK/JNK; stress-activated protein kinase/c-Jun N-terminal kinase; IκB-M; dominant-negative mutant of IκB; PI3K-M; dominant-negative mutant of PI3K; Akt-M; dominant-neg
VEGF-Mediated Survivin Expression in Neuroblastoma Cells
Keywords: neuroblastoma; IMR-32; survivin; VEGF; Akt; LY294002; pediatric tumors;
Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo
Keywords: GSKβ; phospho-ser/thr-Akt substrate; HDI; histone deacetylase inhibitor; LY; LY294002; NF-κB; nuclear factor-κB; NSCLC; non-small cell lung cancer; PI3K; phosphatidylinositol 3-kinase; RT-PCR; reverse transcriptase-polymerase chain reaction; TUNEL; t
Serum withdrawal kills U937 cells by inducing a positive mutual interaction between reactive oxygen species and phosphoinositide 3-kinase
Keywords: ROS; reactive oxygen species; PI3K; phosphoinositide 3-kinase; LY; LY294002; SW; serum withdrawal; SAPK/JNK; stress-activated protein kinase/c-Jun N-terminal kinase; DPI; diphenyleneiodonium; PI3K-M; dominant-negative mutant of the p85 subunit of PI3K; DC
The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation
Keywords: Disorders of the nervous system; Ischemia; Cerebral ischemia/reperfusion (I/R); Akt1; Phosphatidylinositol 3-kinase (PI3K); JNK1/2; c-Jun; Bcl-2; Caspase-3; LY294002; Insulin; Hippocampus;
TG1019/OXE, a Gαi/o-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis
Keywords: 5-Oxo-ETE; TG1019; OXE; Chemotaxis; PI3K; Phospholipase C; ERK; Calcium mobilization; U73122; LY294002; GPCR; Lipid mediator;
Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes
Keywords: AG; AG1478; ASM; acidic sphingomyelinase; ca; constitutively active; CD533; dominant negative ERBB1; DCA; deoxycholic acid; dn; dominant negative; EGF; epidermal growth factor; ERK; extracellular regulated kinase; FADD; FAS associating death domain protei
D-3 phosphoinositides of the ciliate Tetrahymena: Characterization and study of their regulatory role in lysosomal enzyme secretion
Keywords: PtdIns; phosphatidylinositol; PI; phosphoinositide; PtdInsP; phosphatidylinositol phosphate; PtdInsP2; phosphatidylinositol bisphosphate; PtdIns(3)P; phosphatidylinositol 3-phosphate; PtdIns(4)P; phosphatidylinositol 4-phosphate; PtdIns(3,5)P2; phosphatid
PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells
Keywords: K-Cl cotransport; Platelet-derived growth factor; Signal transduction; Phosphoinositide 3-kinase (PI 3-K); Protein phosphatase-1 (PP-1); Wortmannin; LY294002; Vascular smooth muscle;
Adjuvant-induced survival signaling in clonally expanded T cells is associated with transient increases in pAkt levels and sustained uptake of glucose
Keywords: Cytokine; Glucose; Hypoxia; LPS; LY294002; PI3-kinase/pAkt; Superantigen; T cells;