کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9402434 1288540 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
VEGF-Mediated Survivin Expression in Neuroblastoma Cells
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
VEGF-Mediated Survivin Expression in Neuroblastoma Cells
چکیده انگلیسی
VEGF has been shown to up-regulate a number of survival signals in endothelial cells. We have found that exposure of human neuroblastoma cells to exogenous VEGF results in an increased expression of survivin protein and phosphorylated Akt, and inhibition of PI3-kinase abrogates those effects. It appears that VEGF is important for promotion of neuroblastoma cellular survival through the up-regulation of survival proteins, and not only through its angiogenic properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 127, Issue 1, 1 July 2005, Pages 21-28
نویسندگان
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