Keywords: Akt; protein kinase B; ATP; adenosine triphosphate; CK-MB; creatine kinase; EPO; erythropoietin; I/R; ischemia/reperfusion; IPC; ischemic preconditioning; IPOC; ischemic postconditioning; LDH; lactate dehydrogenase; LY294002; PI-3K inhibitor; mito KATP; m
مقالات ISI (ترجمه نشده)
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Keywords: 5-Aminolevulinic acid; Photodynamic therapy; Esophageal carcinoma; AG1478; LY294002; EGFR;
Keywords: AC; adenylate cyclase; Ace; acetophenone; 2-APB; 2-aminoethoxydiphenyl borate; Ben; benzaldehyde; [Ca2+]i; intracellular calcium; CC; chelerythrine chloride; cH; cis-4-heptenal; CNG; cyclic nucleotide-gated; DAG; diacylglycerol; DMSO; dimethyl sulfoxide;
Selenizing astragalus polysaccharide attenuates PCV2 replication promotion caused by oxidative stress through autophagy inhibition via PI3K/AKT activation
Keywords: Selenizing astragalus polysaccharide; PCV2; Oxidative stress; Autophagy; PI3K/AKT; LY294002;
Crosstalk between mAChRM3 and β2AR, via acetylcholine PI3/PKC/PBEP1/Raf-1 MEK1/2/ERK1/2 pathway activation, in human bronchial epithelial cells after long-term cigarette smoke exposure
Keywords: CSE; Cigarette Smoke Extract; ChAT; choline acetyltransferase; ACh; acetylcholine; mAChRs; Muscarinic Acetylcholine receptors; β2ARs; β2 Adrenergic receptors; PEBP1; phosphatidylethanolamine binding protein 1; ROS; Reactive oxigen species; NOX-4; NADPH
Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway
Keywords: Hyperoxia; Hydrogen; AECIIs; LY294002; PI3K/Akt/FoxO3a pathway;
Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line
Keywords: Manganese; STHdh; Neurotoxicity; Manganese transport; PI3K; p53; LY294002; NU7441; KU55933; KU60019;
New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection
Keywords: AMN082; Glia; Staurosporine; Doxorubicin; Glutamate; U0126; LY294002;
Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma
Keywords: ESCC; PI3K; mTOR; PERK; LY294002; GSK2656157; Activating transcription factor 4; ATF4; Esophageal adenocarcinoma; EAC; Esophageal squamous cell carcinoma; ESCC; eukaryotic translation initiation factor 2-alpha; elF2α; phosphorylated elF2α; p-elF2α; Ove
Pancreatic differentiation of induced pluripotent stem cells in activin A-grafted gelatin-poly(lactide-co-glycolide) nanoparticle scaffolds with induction of LY294002 and retinoic acid
Keywords: iPS; Pancreatic islet cell; Differentiation; Insulin; Activin A; LY294002; Retinoic acid; Gelatin-PLGA NP scaffold;
T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation
Keywords: AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; BSA; bovine serum albumin; CQ; chloroquine; EC; endothelial cell; eIF2α; eukaryotic translation initiation factor 2α; ER; endoplasmic reticulum; Erk1/2; extracellular signal-regulated kinase;
Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription
Keywords:  + S; With serum;  â S; Without serum; CHX; Cycloheximide; DMEM; Dulbecco's modified Eagle's medium; ECL; Enhanced chemiluminescence; ETS; Externally transcribed spacer; Exp; Exponentially growing cells; FBS; Fetal bovine serum; h; Hour; LY; LY29400
Lucidone Promotes the Cutaneous Wound Healing Process via Activation of the PI3K/AKT, Wnt/β-catenin and NF-κB Signaling Pathways
Keywords: CDK; cyclin dependent kinase; COX; cyclooxygenase; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; GSK3β; glycogen synthase kinase 3 beta; ICAM; intercellular adhesion molecule; iNOS; inducible nitric oxide synthase; LY294002; (4-morph
Phosphoinositide 3-kinase inhibitor LY294002 ameliorates the severity of myosin-induced myocarditis in mice
Keywords: PI3K; LY294002; Myosin-induced myocarditis
Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia-Reperfusion Injury in Diabetic Rats
Keywords: AAR; area at risk; antimiR; antimicroRNA; C; control; DR; diabetic rat; GLUT4; glucose transporter type 4; IGF-1R; insulinlike growth factor-1 receptor; InsR; insulin receptor; IS; infarct size; L; lentivirus vectors with let-7 antimiR; LY; LY294002; miRN
Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells
Keywords: RSV; resveratrol; NLG; protein N-linked glycosylation; UPR; unfolded protein responses; ER; endoplasmic reticulum; G.F; glucose free media; TM; tunicamycin; PBMC; peripheral blood mononuclear cells; RBC; red blood cells; PERK; protein kinase RNA-like ER k
Tanshinone IIA protects against myocardial ischemia reperfusion injury by activating the PI3K/Akt/mTOR signaling pathway
Keywords: Tanshinone IIA; Myocardial ischemia reperfusion injury; PI3K/Akt/mTOR signaling pathway; Cardiomyocytes; LY294002; Area of necrosis;
Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C
Keywords: aPKC; Atypical protein kinase C; Par6; Partitioning defective-6; EMT; Epithelial-mesenchymal transition; PC; Pancreatic cancer; CS; Cigarette smoking; nAChR; Nicotine acetylcholine receptor; PI3K; Phosphatidylinositol 3-kinase; MCA; Mecamylamine hydrochlo
Intranasal delivery of bFGF with nanoliposomes enhances in vivo neuroprotection and neural injury recovery in a rodent stroke model
Keywords: BBB; blood-brain barrier; bFGF; basic fibroblast growth factor; bFGF-NL; bFGF encapsulated nanoliposomes; CCA; common carotid artery; CNS; central nervous system; ECA; external carotid artery; ICA; internal carotid artery; I/R; ischemia-reperfusion; N
Effect of LIF-withdrawal on acetylcholine synthesis in the embryonic stem cell line CGR8 is not mediated by STAT3, PI3Ks or cAMP/PKA pathways
Keywords: ACh; acetylcholine; HPLC; high pressure liquid chromatography; DMSO; dimethylsulfoxide; FCS; fetal calf serum; FLLL31; (E,E)-1,7-Bis(3,4-dimethoxy-phenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione; H89; N-[2-(p-Bromocin-amino) ethyl]-5-isoquinolinesulfonamide
Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling
Keywords: Chemo-sensitization; PI3K; LY294002; Mitochondria; Sab; JNK;
Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3â²,4â²-dihydroxyflavonol
Keywords: Flavonol; Myocardial ischemia/reperfusion injury; Oxidative stress; Survival kinases; ERK1/2; Akt; PD98059; LY294002;
PI3K/Akt/p53 pathway inhibits reovirus infection
Keywords: CHT; α-Chymotrypsin; LY; LY294002; Wort; Wortmannin; p-Akt; phosphorylated Akt; p-MDM2; phosphorylated MDM2; Reovirus; PI3K/Akt; p53; MDM2; Replication;
Comparison between endothelial and tumor cells in the response to verteporfin-photodynamic therapy and a PI3K pathway inhibitor
Keywords: Photodynamic therapy (PDT); Verteporfin; Phosphatidylinositol 3-kinase (PI3K) inhibitor; LY294002; Apoptosis;
Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells
Keywords: Curcumin; Breast cancer; Apoptosis; PI3K; LY294002
Gastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanisms
Keywords: CCK; COOH-terminal octapeptide of cholecystokinin; TPA; 12-O-tetradecanoylphorbol-13-acetate; PAKs; p21-activated kinases; SFK; Src family of kinases; PKC; protein kinase C; PYK2; proline-rich tyrosine kinase 2; FAK; focal adhesion kinase; PKD; protein ki
Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways
Keywords: APL; acute promyelocytic leukemia; ATO; arsenic trioxide; ATRA; all-trans retinoic acid; DQA; dequalinium; GSH; glutathione; NB4; human acute promyelocytic leukemia derived cell line; PML; promyelocytic leukemia; ROS; reactive oxygen species; Dequalinium;
Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2
Keywords: Dynasore; PD98059; BFA; SecinH3; LY294002; QS11; PBP10ARF, ADP-ribosylation factor; PI, phosphatidylinositol; PI3K, PI 3-kinase; PIP2, PI 4,5-bisphosphate; PIP3, PI 3,4,5-trisphosphate; ERK, extracellular-signal regulated kinase; MAPKK, mitogen-activated
Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells
Keywords: DHE; dihydroethidium; DHR; dihydrorodamine 123; HG; high glucose; LY; LY294002; LPO; lipid peroxidation; NBT; nitrotetrazolium blue; PC; protein carbonylation; U1; PD98059; U2; U0126; WT; wortmannin; Glial cells; Hyperglycemia; Oxidative-nitrosative stres
The effect of PI3 kinase inhibitor LY294002 on voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
Keywords: LY294002; Voltage-dependent K+ channel; Coronary artery;
Arachidonic acid enhances TPA-induced differentiation in human leukemia HL-60 cells via reactive oxygen species-dependent ERK activation
Keywords: AA; Arachidonic acid; AML; Acute myeloid leukemia; BCIP; 5-bromo-4-chloro-3-indolyl phosphate; DMSO; Dimethyl sulfoxide; ERK; Extracellular regulated kinase; LY; LY294002; NAC; N-acetyl-cysteine; NBT; Nitroblue tetrazolium; JNK; c-Jun N-terminal kinase; P
Increase of oxidative stress by a novel PINK1 mutation, P209A
Keywords: AD; Alzheimer disease; ERK; extracellular signal-regulated kinase; MTT; 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolum bromide; HO-1; heme oxygenase-1; LDH; lactate dehydrogenase; LY294002; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; MEM; mini
Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells
Keywords: MOR; mu opioid receptor; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein/extracellular signal-regulated kinase; NF-κB; nuclear factor-kappaB; DP; distal promoter; PP; proximal promoter; Oct-1; octame
Switching from MAPK-dependent to MAPK-independent repression of the sodium-iodide symporter in 2D and 3D cultured normal thyroid cells
Keywords: EGF; epidermal growth factor; EMT; epithelial to mesenchymal transition; ERK1/2; extracellular-signal regulated kinase 1/2; FBS; fetal bovine serum; IGF-1; insulin-like growth factor-1; LY294002; PI3K inhibitor; MAPK; mitogen-activated protein kinase; MEK
Adenosine A1 receptor stimulation enhances osteogenic differentiation of human dental pulp-derived mesenchymal stem cells via WNT signaling
Keywords: ADA; adenosine deaminase; A1R; adenosine A1 receptors; A2AR; adenosine A2A receptors; A2BR; adenosine A2B receptors; A3R; adenosine A3 receptors; ALP; alkaline phosphatase; ARS; Alizarin Red S staining; CCPA; 2-chloro-N6-cyclopentyladenosine; CGS21680; 2-
PI3 k/akt inhibition induces apoptosis through p38 activation in neurons
Keywords: AKT; LY294002; p38 MAPK; BH3 only proteins; Dp5; Bim; Neurons
Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases
Keywords: PI3Ks; phosphatidylinositol 3-kinases; PIP3; phosphatidylinositol 3,4,5-triphosphate; QPLD; Quantum-Polarized Ligand Docking; PI3K; Docking; Pharmacophore modeling; Apoptosis; LY294002; GSK2126458;
C-peptide induces human renal mesangial cell proliferation in vitro, activating Src-kinase, PI-3 kinase and ERK1/2
Keywords: CDK4; cyclin-dependent kinase 4; DAPI; 4â²,6-diamidino-2-phenylindole; ERK1/2; extracellular-signal-regulated kinases; LY294002; PI-3 kinase inhibitor; MC; mesangial cells; PD98059; MAP/ERK kinase inhibitor; PDGF; platelet derived growth factor; PP2; pro
FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells
Keywords: AA; Activin A; Cyclo; KAAD-cyclopamine; DE; definitive endoderm; F; FGF2; HBPI; hepatocyte blockade and pancreas induction stage; hESCs; human embryonic stem cells; LY; LY294002; NG; Noggin; PNP; PDX1- and NKX6.1-positive pancreatic progenitor; PPP; PDX1-
PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter
Keywords: ABC, ATP-binding cassette; PI3K, phosphatidylinositol 3-kinase; mTOR, mammalian target of rapamycin; MDR, multidrug resistanceABCG2; PI3-kinase/Akt/mTOR signaling; LY294002; Wortmannin; Rapamycin
Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cells
Keywords: UDCA; ursodeoxycholic acid; TUDCA; tauroursodeoxycholic acid; YS; Yoo's solution; SNP; sodium nitroprusside; ROS; reactive oygen species; RNS; reactive nitrogen species; NO; nitric oxide; PD; Parkinson's disease; PI3K; phosphatidylinositol-3-kinase; PKA;
Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway
Keywords: BK; large (big) conductance Ca2+-activated K+ channels; DPCPX; 1,3-dipropyl-8-cyclopentylxanthine; GUO; guanosine; GSK-3β; glycogen synthase kinase 3β; H2DCFDA; 2â²,7â²-dichlorofluorescein diacetate; HO-1; heme oxygenase-1; LY294002; 2-(4-morpholinyl)
Anti-amnesic effect of neurosteroid PREGS in Aβ25-35-injected mice through Ï1 receptor- and α7nAChR-mediated neuroprotection
Keywords: Pregnenolone sulfate (PREGS); β-Amyloid (Aβ); α7 nicotinic acetylcholine receptor (α7nAChR); Sigma-1 receptor (Ï1R); AD; Alzheimer's disease; Aβ; β-amyloid; DMXB; 3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride; LY294002; 2-(4-morpholinyl)-
The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells
Keywords: CRC; colorectal cancer; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescence; ESI; electrospray ionization; FCS; fetal calf serum; HRP; horse-radish peroxidase; IC50; half maximal inhibitory concentration; IEF; isoelectric focusing; IPG; immobilized
Redox control of cytosolic Akt phosphorylation in PTEN null cells
Keywords: AMS; 4-acetamido-4-maleimidylstilbene-2, 2-disulfonic acid; DDC; diethyldithiocarbamate; DMSO; dimethyl sulfoxide; DPI; diphenyleneiodonium; MEFWT; wild-type mouse embryonic fibroblasts; MEFPTENâ/â; PTEN knockout mouse embryonic fibroblasts; O2â¢â;
Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
Keywords: Doxorubicin; DNA polymerase eta (pol eta); XPV; XPA; LY294002; DNA repair;
Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons
Keywords: CGNs; cerebellar granule neurons; S/K; serum potassium deprivation; CDK; cyclin-dependent kinase; JNK; c-Jun N-terminal kinase; GSK3β; glycogen synthase kinase 3β; PI3K; phosphatidylinositol-3 kinase; IGF-1; insulin-like growth factor-I; CDK5/p25; LY294
Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-κB pathways
Keywords: PI3K/Akt pathway; Apoptosis; LY294002; NF-κB; PKHD1;
Activation of a non-genomic Pim-1/Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells
Keywords: AR; androgen receptor; Bad; Bcl-xL; LY294002; Pim-1; Prostate cancer;
Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells
Keywords: AKT/PKB; protein kinase B; BrDU; 5-bromo-2â²-deoxyuridine; CRC; colorectal cancer; DCFH; 2â²,7â²-dichlorofluorescin diacetate; DTT; dithiothreitol; EC; epicatechin; ECG; epicatechin gallate; EGCG; epigallocatechin-3-gallate; ERK; extracellular regulate