Redox control of cytosolic Akt phosphorylation in PTEN null cells

► A redox-dependent regulation of Akt phosphorylation in PTEN null cells. ► Redox imbalance in PTEN null cells increases intracellular reducing capacity. ► Reduced cytosolic milieu in PTEN null cells prevents Akt Thr308 dephosphorylation. ► Decrease in superoxide favors dephosphorylation of cytosolic Akt by PP2A.