Keywords: CGS 19755; LY354740; Alcohol sensitization; Microdialysis; MK-801; NMDA receptors;
مقالات ISI (ترجمه نشده)
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Keywords: ANOVA; analysis of variance; GABA; γ-aminobutyric acid; SEM; standard error of the mean; NMDA; N-methyl-d-aspartate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; iGluRs; ionotropic glutamate receptors; mGluRs; metabotropic glutamate recep
Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2
Keywords: Metabotropic glutamate receptor; mGlu2; mGlu3; mGluR; Negative allosteric modulators; Positive allosteric modulators; LY354740; LY487379; ECL; extracellular loop; FLIPR; Fluorometric Imaging Plate Reader; GPCR; G-protein coupled receptor; mGluR; metabotro
The neuroprotective effects of orthosteric agonists of group II and III mGluRs in primary neuronal cell cultures are dependent on developmental stage
Keywords: ACPT-I; LY354740; VU0361737; AMN082; Staurosporine; Doxorubicin; Glutamate; Primary neuronal cell cultures
Group II metabotropic glutamate receptor antagonism prevents the antiallodynic effects of R-isovaline
Keywords: ANOVA; analysis of variance; CGP52432; (3-[[[(3,4-dichlorophenyl)methyl]amino]propyl]diethoxymethyl)phosphinic acid; CI; confidence interval; CNS; central nervous system; GABA; γ-aminobutyric acid; GPCRs; G-protein-coupled receptors; l-AP4; l-(+)-2-amino
Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors
Keywords: Mediodorsal thalamus; Metabotropic glutamate receptor; Synaptic inhibition; Burst firing; Schizophrenia; DMSO; dimethyl sulfoxide; GABA; gamma-amino butyric acid; i.p.; intraperitoneal; LY354740; (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic
Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation
Keywords: ACPT-I; LY354740; VU0361737; AZ12216052; AMN082; AIFAIF, apoptosis inducing factor; Dox, doxorubicin; FBS, fetal bovine serum; GABA, γ-aminobutyric acid; GPCRs, G-protein-coupled receptors; iGluRs, ionotropic glutamate receptors; LDH, lactate dehydrogenas
Delayed treatments with pharmacological modulators of pre- and postsynaptic mGlu receptors rescue the hippocampus from kainate-induced neurodegeneration
Keywords: Excitotoxicity; Kainic acid; Hippocampus; MPEP; LY354740; Fluoro-Jade;
Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740
Keywords: Prenatal stress; Schizophrenia; Rab GDI; LY379268; LY354740;
Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state
Keywords: ACPT-I; LY354740; VU0361737; (S)-3,4-DCPG; AZ12216052; AMN082; Necrostatin-1; [3H]MPP(+) uptake; mGluR II/III expression6-OHDA, 6-hydroxydopamine; DAT, dopamine transporter; FBS, fetal bovine serum; GABA, γ-aminobutyric acid; GPCRs, G-protein-coupled rece
Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist
Keywords: Metabotropic glutamate receptors; mGlu2; mGlu3; Temporo-ammonic pathway; Phencyclidine; Amphetamine; Hyperlocomotion; DCG-IV; (2S,2â²R,3â²R)-2-(2â²,3â²-dicarboxycyclopropyl)glycine; LY354740; (1S,2S,5R,6S)-(+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxy
Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; analysis of variance; BSA; bovine serum albumin; DG; dentate gyrus; EAAT1/GLAST; excitatory amino acid transporter 1; KO; knockout; LY354740; (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists
Keywords: Metabotropic glutamate receptors; 1,3-Dihydro-benzo[b][1,4]diazepin-2-one; mGluR2 antagonist; mGluR3 antagonist; LY354740; In vivo activity; Rats; Cognition models
The Intestinal Absorption of a Prodrug of the mGlu2/3 Receptor Agonist LY354740 is Mediated by PEPT1: In Situ Rat Intestinal Perfusion Studies
Keywords: peptide transporters; PEPT1; prodrugs; intestinal absorption; in situ intestinal perfusion; LY544344; LY354740; membrane transport/transporters; active transport; GlyâSar;
Comparison of the mGlu5 receptor positive allosteric modulator ADX47273 and the mGlu2/3 receptor agonist LY354740 in tests for antipsychotic-like activity
Keywords: Prepulse inhibition; Locomotor activity; mGlu5 receptor positive allosteric modulator; mGlu2/3 receptor agonist; ADX47273; LY354740
Metabotropic Glutamate Receptors as Targets for Multipotential Treatment of Neurological Disorders
Keywords: Astrocytes; inflammation; metabotropic glutamate receptors; microglia; neuron; neuroprotection; 4CPG; (S)-4-carboxyphenylglycine; 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid; AIDA; 1-aminoindan-1, 5-dicarboxylic acid; ALS; amyotrophic lateral sclerosis; AM
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists
Keywords: Metabotropic glutamate receptors; mGluR2; LY354740; Non-competitive antagonists; 1,3-Dihydro-benzo[b][1,4]diazepin-2-ones; Excitatory postsynaptic potentials
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists
Keywords: Metabotropic glutamate receptors; 1,3-Dihydro-benzo[b][1,4]diazepin-2-one; mGluR2 antagonist; LY354740; In vivo activity; Mice
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1
Keywords: Metabotrophic glutamate receptors; mGluR2; LY354740; 1,3-Dihydro-benzo[b][1,4]diazepin-2-one; mGluR2/3 antagonists; Non-competitive antagonists
Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
Keywords: Anxiety; Depression; LY354740; mGlu receptors; MPEP; MTEPBehavioral test; 4PT, 4-plate test; CER, conditioned emotional response; CFC, contextual fear conditioning; CFS, conditioned fear stress; CMS, chronic mild stress; EZM, elevated zero maze; FPS, fear
Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus
Keywords: Metabotropic glutamate receptors; Anxiolytic; Antipsychotic; LY354740; Thalamus; Edinger-Westphal nucleus