Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist

► First description of LY541850 on native mGlu2/3 receptors. ► LY541850 is an orthosteric mGlu2 agonist and mGlu3 antagonist. ► Both mGlu2 and mGlu3 receptors inhibit hippocampal synapses. ► LY541850 mimics the action of mixed mGlu2/3 agonists in models of schizophrenia.