Keywords: لاین; Huang-Lian-Jie-Du extract; Atopic dermatitis; Degranulation; MAPKs; NF-κB; Lyn
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Keywords: لاین; AP1; Activator protein 1; cAMP; Cyclic adenosine monophoshate; CXCR; Cytokine receptors; CRTH2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; DAMPs; Damage-associated molecular pattern; EtBr; Ethidium Bromide; IgE; Immunoglobulin E;
Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn
Keywords: لاین; Vibsanin A; Tyrosine kinase inhibitor; Differentiation; Protein kinase C; Lyn;
Decreased intracellular chloride promotes ADP induced platelet activation through inhibition of cAMP/PKA instead of activation of Lyn/PI3K/Akt pathway
Keywords: لاین; Chloride; ACI; Lyn; Gαi2; cAMP; PKA;
Long-chain glucosylceramides crosstalk with LYN mediates endometrial cell migration
Keywords: لاین; Cer; ceramide; GlcCer; glycosylceramide; HESC; human endometrial stromal cell; GCS; glucosylceramide synthase; LC-MS/MS; liquid chromatography-tandem mass spectrometry; SDF-1α; stromal cell-derived factor 1alpha; CXCR4; CXC chemokine receptor 4; Glycosyl
ATF3 and PRAP1 play important roles in cisplatin-induced damages in microvascular endothelial cells
Keywords: لاین; GO; Gene Ontology; KEGG; Kyoto Encyclopedia of Genes and Genomes; DEGs; differentially expressed genes; CDDP; cisplatin; CVD; cardiovascular disease; ATF3; Activating Transcription Factor 3; PRAP1; proline-rich acidic protein 1; HMEC-1; human microvascula
Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway
Keywords: لاین; Lymphoma; Anti-cancer; Lyn; ERK; Triptonide;
Protein profiling and angiogenic effect of hypoxia-cultured human umbilical cord blood-derived mesenchymal stem cells in hindlimb ischemia
Keywords: لاین; ABL; abelson murine leukemia viral oncogene homolog; BCL-XL; B-cell lymphoma-extra large; Cy; Cyanine; DAVID; Database for annotation visualization and integrated discovery; DNA-PK; DNA-activated protein kinase; 4E-BP1; eukaryotic initiation factor 4E-bin
Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Syk activation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C
Keywords: لاین; 8-Formyl-7-hydroxy-4-methylcoumarin; 4μ8C; Mast cells; Allergy; Anaphylaxis; Lyn; Fyn; BMMC; Bone marrow-derived mast cell; RBL; Rat basophilic leukemia; PCA; Passive cutaneous anaphylaxis; ITAM; Immunoreceptor tyrosine-based activation motif; DNP-BSA; D
A novel homolog of protein tyrosine kinase Fyn identified in Lampetra japonica with roles in the immune response
Keywords: لاین; Fyn; Proto-oncogene tyrosine-protein kinase Fyn; Lja-Fyn; Fyn-like of Lampetra japonica; RACE; Rapid Amplification of cDNA Ends; qPCR; Real-time quantitative PCR detecting system; Src; Proto-oncogene tyrosine-protein kinase Src; Yes; Yamaguschi sarcoma vi
Grouper (Epinephelus coioides) BCR signaling pathway was involved in response against Cryptocaryon irritans infection
Keywords: لاین; Epinephelus coioides; Cryptocaryon irritans; CD79; LYN; SYK
Micronome revealed miR-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma
Keywords: لاین; OSCC; Oral Squamous Cell Carcinoma; miRNA; MicroRNA; NGS; Next Generation Sequencing; STRING; Search Tool for Retrieval of Interacting Genes/Proteins; ACTREC; Advanced Centre for Treatment Research and Education in Cancer; HNOCDB; Head Neck Oral Cancer Da
Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells
Keywords: لاین; 6His; hexahistidine tag; aa; amino acids; Bcl-2; apoptosis regulator B-cell CLL/lymphoma 2; cAMP; cyclic adenosine monophosphate; CCNC; cyclin C; CCPG1; cell cycle progression protein 1; CDK6; cyclin-dependent kinase 6; cDNA; coding DNA; CXCR4; chemokine
GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation
Keywords: لاین; Retinoic acid; Leukemia; Resistance; Inhibitors; c-Raf; Lyn
The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils
Keywords: لاین; BSA; bovine serum albumin; cAMP; cyclic AMP; DPI; diphenyliodonium; ELISA; enzyme-linked immune-sorbent assay; ERK; extracellular signal-regulated kinase; FLPEP; N-formyl-nor-leucyl-leucyl-phenylalanyl-norleucyl-throsyl-lysine-fluorescein; fMLP; N-formyl-
Epstein-Barr virus Latent Membrane Protein 2A (LMP2A)-mediated changes in Fas expression and Fas-dependent apoptosis: Role of Lyn/Syk activation
Keywords: لاین; B cells; Epstein-Barr virus; Latency Membrane Protein 2A (LMP2A); B cell receptor (BCR); Lyn; Syk; Fas (CD95); Apoptosis; PARP;
Regulation of alkaline ceramidase activity by the c-Src-mediated pathway
Keywords: لاین; Ceramidase; Sphingolipid metabolism; c-Src; Lyn; Vanadate
A crucial role for Lyn in TIMP-1 erythroid cell survival signalling pathway
Keywords: لاین; TIMP-1; Erythroleukemic cell; Cell survival; Lyn;
Effect of endocannabinoids on IgE-mediated allergic response in RBL-2H3 cells
Keywords: لاین; 2-AG; 2-arachidonoyl glycerol; 5-LO; 5-lipoxygenase; Akt; protein kinase B; CB; cannabinoid; COX-2; cyclooxygenase-2; cPLA2; cytosolic phospholipase A2; ERK1/2; extracellular signal-regulated kinase 1/2; FAAH; fatty acid amide hydrolase; Gab2; GRB2-associ
Molecular identification and expression of Lyn tyrosine kinase isoforms in marsupials
Keywords: لاین; Immune signalling; Lyn; Marsupial; Protein tyrosine kinase; Wallaby
Formation of BCR oligomers provides a mechanism for B cell affinity discrimination
Keywords: لاین; Antigen; B cell receptor; Lymphocyte signaling; Lyn; Monte Carlo;
Treatment with TNFα blockers induces phenotypical and functional aberrations in peripheral B cells
Keywords: لاین; Anti-TNFα; Lyn; CD20; SLE; Autoimmunity; B cells; CD5
A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells
Keywords: لاین; Akt; IL-6; Lyn; Myeloma; PI 3-kinase; Proliferation
Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: Implications for regulation of IgE-mediated degranulation
Keywords: لاین; Spleen tyrosine kinase (Syk); Lyn; RBL-2H3; IgE; FcɛRI; R406; BAY61-3606; Degranulation
Structural basis for the inhibitor recognition of human Lyn kinase domain
Keywords: لاین; Lyn; Src family; Kinase; Structure; Inhibitor
Lyn inhibits osteoclast differentiation by interfering with PLCγ1-mediated Ca2+ signaling
Keywords: لاین; Osteoclast; Lyn; RANKL
Association between reduced levels of total serum IgE and FcεRI expression in non-releaser basophils
Keywords: لاین; Basophils; Histamine non-releasers; IgE; FcεRI; Lyn; Syk
Requirement of the SH4 and tyrosine-kinase domains but not the kinase activity of Lyn for its biosynthetic targeting to caveolin-positive Golgi membranes
Keywords: لاین; Golgi caveolin; Kinase domain; Lipid modification; Lyn; Src-family tyrosine kinase; Targeting;
The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling
Keywords: لاین; Epstein–Barr virus (EBV); Latent membrane protein 2A (LMP2A); c-Cbl; Lyn; Syk; Ubiquitin; Lytic replication
Protein purification and preliminary crystallographic analysis of human Lyn tyrosine kinase
Keywords: لاین; Lyn; Src family; Tyrosine kinase; Crystallization; Phosphorylation
Kit- and FcÉRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells
Keywords: لاین; Mast cells; FcÉRI; Kit; NTAL; Lyn; Syk; Signaling; Adaptor molecules;
Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity
Keywords: لاین; Src-family tyrosine kinases; Lyn; Lipid modification; Nucleocytoplasmic transport; Leptomycin B; Nuclear export; Tyrosine kinase activity
Role of Src-family kinases in formation of the cortical actin cap at the dorsal cell surface
Keywords: لاین; Src-family tyrosine kinase; Cortical actin cap; Lyn; c-Src; Actin filaments; Protein-tyrosine phosphatase; Tyrosine phosphorylation; Csk; Cdc42;
Infections, B cell receptor activation and autoimmunity: Different check-point impairments lead to autoimmunity, clonal B cell expansion and fibrosis in different immunological settings
Keywords: لاین; B cell receptor; Inhibiting kinases; Activating kinases; Lyn; Syk; Chronic lymphocytic leukaemia; Hepatitis C; SLE; RA; SSc
Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives
Keywords: لاین; Kinase; Inhibitor; Abl; Lyn; Tyrosine kinase; X-ray; Molecular modeling; QSAR
Histamine releasibility and expression of Lyn and Syk kinases in Indian subjects and role of less potent IL-3 in non-releaser basophils
Keywords: لاین; Basophils; Histamine non-releasers; IgE; IL-3; Lyn; Syk
Identification of the flavoprotein of succinate dehydrogenase and aconitase as in vitro mitochondrial substrates of Fgr tyrosine kinase
Keywords: لاین; COX, cytochrome c oxidase; FpSDH, flavoprotein of succinate dehydrogenase; RBM, rat brain mitochondriaMitochondria; Tyrosine kinase; Fgr; Lyn; Substrate
Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells
Keywords: لاین; Src-family tyrosine kinase; c-Src; c-Yes; Lyn; Fyn; Cdc2; Mitosis; M phase; Phosphorylation; Electrophoretic mobility
Nonreceptor Tyrosine Kinases in Prostate
Keywords: لاین; Nonreceptor tyrosine kinase; prostate cancer; Src; FAK; ETK; Abl; v-Abl Abelson murine leukemia viral oncogene homolog; At; androgenindependent; Aid; v-akt murine thymoma viral oncogene homolog 1; AR; androgen receptor; ARG; Abelson-related gene; Bcr; bre
Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes
Keywords: لاین; c-Src; Cytosol; Golgi apparatus; Focal adhesion; Late endosome/lysosome; Lyn; Non-vesicular transport; Palmitoylation; Photobleaching; Trafficking
In vivo antiproliferative effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on leukemic cells harbouring Abl kinase domain mutations
Keywords: لاین; NS-187; Bcr-Abl; Lyn; Chronic myeloid leukemia; Imatinib
CrkL plays a role in SDF-1-induced activation of the Raf-1/MEK/Erk pathway through Ras and Rac to mediate chemotactic signaling in hematopoietic cells
Keywords: لاین; CrkL; SDF-1; Lyn; Chemotaxis; Rac; Ras; Rap1; Erk
The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules
Keywords: لاین; Pancreas; src; src kinase; lyn; Cholecystokinin; Pancreatic secretion; Pancreatic growth; Pancreatic growth factor
Molecular regulation of mast cell activation
Keywords: لاین; FcɛRI; Lyn; Fyn; IgE; mast cell; degranulationAkt/PKB, Protein kinase B; BMMC, Bone marrow–derived mast cell; Btk, Bruton's tyrosine kinase; Csk, COOH-terminal Src kinase; DAG, Diacylglycerol; ERK, Extracellular signal-regulated kinase; Gab2, Grb2-associa
Involvement of Golgi-associated Lyn tyrosine kinase in the translocation of annexin II to the endoplasmic reticulum under oxidative stress
Keywords: لاین; Annexin II; Endoplasmic reticulum (ER); Golgi; HeLa; Hydrogen peroxide; Lyn; Signal transduction; Src-family kinases; Trafficking; Tyrosine phosphorylation
Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells
Keywords: لاین; Kit; Stem cell factor; Lyn; Tyrosine kinases; Signal transduction; Hematopoiesis;
Syk and Lyn phosphorylation induced by FcγRI and FγRII crosslinking is determined by the differentiation state of U-937 monocytic cells
Keywords: لاین; Fc receptors; Lyn; Syk; Monocyte differentiation; Signal transduction;
Protein phosphatase 1α is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr
Keywords: لاین; Peroxynitrite; Serine/threonine protein phosphatase; Src family tyrosine kinase; K-Cl cotransport; Tyrosine phosphorylation; Oxidative stress; Red blood cell; fgr; feline Gardner-Rasheed; hck; hematopoietic cell kinase; lyn; lck/yes-related novel tyrosine
Signaling by Kit protein-tyrosine kinase-The stem cell factor receptor
Keywords: لاین; Akt; APS; Bad; Cancer; Cbl; Dok1; Erk; Fyn; Grb2; Grb7; Hematopoiesis; Leukemia cell lines; Lyn; MAP kinase; Mast cell; Oncogene; Piebaldism; Protein kinase; Protein phosphatase; Proto-oncogene; Ras; Shp1; Shp2; Src family kinase;