Keywords: لیپاز لیزوزوم اسید; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
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Keywords: لیپاز لیزوزوم اسید; Lysosomal acid lipase; Lysosomal acid lipase deficiency; Hepatomegaly; Dyslipidemia; Cholesteryl ester storage disease; Lipasa ácida lisosomal; Deficiencia de lipasa ácida lisosomal; Hepatomegalia; Dislipidemia; Enfermedad por depósito de ésteres de c
Keywords: لیپاز لیزوزوم اسید; Lipasa ácida lisosomal; Deficiencia de lipasa ácida lisosomal; Hepatomegalia; Dislipidemia; Enfermedad por depósito de ésteres de colesterol; Lysosomal acid lipase; Lysosomal acid lipase deficiency; Hepatomegaly; Dyslipidemia; Cholesteryl ester storag
Keywords: لیپاز لیزوزوم اسید; ADA; anti-drug antibodies; AMPK; 5â² adenosine monophosphate-activated protein kinase; aHUS; atypical hemolytic uremic syndrome; AMD; age-related macular degeneration; APC; antigen presenting cells; AT; anaphylatoxin; BTK; Bruton's tyrosine kinase; C1q
Keywords: لیپاز لیزوزوم اسید; Niemann Pick type C; Lysosomal acid lipase deficiency; Osmotic haemolysis; Cholesterol-related lysosomal diseases; Screening test; red blood cells; RBC; lysosomal storage diseases; LSDs; Niemann-Pick type C disease; NPC; lysosomal acid lipase; LAL; lysoso
Keywords: لیپاز لیزوزوم اسید; Lysosomal acid lipase deficiency; Cholesteryl ester storage disease (CESD); Wolman disease; Liver failure; Liver transplantation; Enzyme replacement therapy; Lysosomal storage disease; LAL-D; Lysosomal acid lipase deficiency; LSD; lysosomal storage diseas
Keywords: لیپاز لیزوزوم اسید; 2-AG; 2-arachidonoylglycerol; AADAC; arylacetamide deacetylase; ABHD5/CGI-58; alpha-beta-hydrolase domain containing 5/comparative gene identification-58; ATGL/ PNPLA2; adipose triglyceride lipase; CE; cholesteryl esters; CES/Ces; carboxylesterase; DG; di
Keywords: لیپاز لیزوزوم اسید; ATGL; adipose triglyceride lipase; CE; cholesterol ester; CESD; cholesterol ester storage disease; CMA; chaperone-mediated autophagy; CREB; cAMP response element binding protein; FA; fatty acid; FOXO; forkhead box O proteins; FXR; farsenoid X receptor; HS
Keywords: لیپاز لیزوزوم اسید; APO; apolipoprotein; ACS; acyl-CoA synthetase; ACSL; acyl-CoA synthetase, long chain; ACAT; acyl-CoA:cholesterol acyltransferase; AGPAT; acylglycerophosphate acyltransferase; ATGL; adipocyte triglyceride lipase; 3BHS1; 3-Beta-hydroxysteroid dehydrogenase;
Keywords: لیپاز لیزوزوم اسید; Lysosomal acid lipase; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Metabolic syndrome; Statins
Keywords: لیپاز لیزوزوم اسید; HDL; Atherosclerosis; Cholesteryl ester storage disease; Lipoproteins; Lysosomal acid lipase; Cholesterol efflux capacity; Cholesterol loading capacity;
Keywords: لیپاز لیزوزوم اسید; Lysosomal acid lipase; Lysosomal acid lipase deficiency; DNA mutational analysis; LIPA; Cholesterol; Cholesteryl ester storage disease; Wolman disease;
Keywords: لیپاز لیزوزوم اسید; LAL; lysosomal acid lipase; TG; triglycerides; CE; cholesteryl esters; WD; Wolman disease; CESD; cholesterol ester storage disease; ET; enzyme therapy; rhLAL; recombinant human LAL; 4-MUO; 4-methylumbelliferyloleate; ORO; Oil Red-O; Lysosomal acid lipase;
Keywords: لیپاز لیزوزوم اسید; CESD; cholesteryl ester storage disease; LAL; lysosomal acid lipase; CE; cholesteryl ester; TG; triglyceride; ERT; enzyme replacement therapy; NAFLD; non-alcoholic fatty liver disease; Wolman disease; Cholesteryl ester storage disease; 1H MR spectroscopy;
Keywords: لیپاز لیزوزوم اسید; 1,25(OH)2D; 1,25 dihydroxy vitamin D (calcitriol); 3βHSD; 3β-hydroxysteroid dehydrogenase; ACAT; acyl transferase; ACTH; adrenocorticotropic hormone; ANT; adenine nucleotide transporter; ER; endoplasmic reticulum; CRAC; cholesterol recognition amino aci
Impact of loss of SOAT2 function on disease progression in the lysosomal acid lipase-deficient mouse
Keywords: لیپاز لیزوزوم اسید; CESD; cholesteryl ester storage disease; DKO; double knockout; EC; esterified cholesterol; ERT; enzyme replacement therapy; LAL; lysosomal acid lipase; LCAT; lecithin:cholesterol transferase; SOAT1; sterol O-acyltransferase 1; SOAT2; sterol O-acyltransfer
Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver
Keywords: لیپاز لیزوزوم اسید; ALT; alanine aminotransferase; AST; aspartate aminotransferase; EC; esterified cholesterol; ERT; enzyme replacement therapy; LAL; lysosomal acid lipase; LIPA; gene that encodes LAL; NPC1L1; Niemann-Pick C1-Like1; SI; small intestine; SOAT2; sterol O-acylt
Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter, Niemann-Pick type C1
Keywords: لیپاز لیزوزوم اسید; ABCA1; ATP binding cassette transporter A1; ABCG1; ATP binding cassette transporter G1; bw; body weight; Cav-1; Caveolin-1; EC; esterified cholesterol; CYP27A1; sterol-27 hydroxylase; FVB; Friend Leukemia Virus; LAL; lysosomal acid lipase; Npc1; Niemannâ
Research ArticleSebelipase alfa over 52Â weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency
Keywords: لیپاز لیزوزوم اسید; LAL; lysosomal acid lipase; LAL D; lysosomal acid lipase deficiency; CE; cholesteryl ester; TG; triglycerides; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; MRI; magnetic resonance imaging; MRS; magnetic resonance spectros
Heterozygosity for lysosomal acid lipase E8SJM mutation and serum lipid concentrations
Keywords: لیپاز لیزوزوم اسید; Cholesterol ester storage disease; E8SJM carriers; Lipids; Genetic analysis; Lysosomal acid lipase; CESD; cholesterol ester storage disease; LAL; lysosomal acid lipase; E8SJM; exon 8 splice junction mutation;
The Cholesterol Derivative 27-Hydroxycholesterol Reduces Steatohepatitis in Mice
Keywords: لیپاز لیزوزوم اسید; Metabolic Syndrome; Fatty Liver; NAFLD; Mouse Model; 27HC; 27-hydroxycholesterol (25(R)26 hydroxycholesterol); ALT; alanine aminotransferases; COL1A1; collagenase 1A1; CTX; cerebrotendinous xanthomatosis; HFC; high-fat high cholesterol; IL; interleukin; K
A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2
Keywords: لیپاز لیزوزوم اسید; Lysosomal acid lipase; Dried blood spot; Method; Lalistat 2; Wolman disease; Cholesterol ester storage disease;
Structural bases of Wolman disease and cholesteryl ester storage disease
Keywords: لیپاز لیزوزوم اسید; Wolman disease; Cholesteryl ester storage disease; Lysosomal acid lipase; Structure
Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: A potential contributory factor in diabetes-associated atherosclerosis
Keywords: لیپاز لیزوزوم اسید; Cathepsin; Hyperglycaemia; Lysosomal acid lipase; Lysosomes; Macrophage;
Intracellular sterol dynamics
Keywords: لیپاز لیزوزوم اسید; PM; plasma membrane; ER; endoplasmic reticulum; ERC; endosomal recycling compartment; LE; late endosome; LY; lysosome; LSO; LE/LY-like storage organelle; PC; phosphatidylcholine; SM; sphingomyelin; PS; phosphatidylserine; PE; phosphatidylethanolamine; DO;
Chemical screen to reduce sterol accumulation in Niemann–Pick C disease cells identifies novel lysosomal acid lipase inhibitors
Keywords: لیپاز لیزوزوم اسید; Cholesterol accumulation; Lysosomal storage organelles; Lysosomal acid lipase; Orlistat; NPC
Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages
Keywords: لیپاز لیزوزوم اسید; ACAT-1; acyl CoA cholesterol acyltransferase; BSA; bovine serum albumin; CEH; cholesteryl ester hydrolase; CES1; carboxylesterase 1; CES2; carboxylesterase 2; CPO; chlorpyrifos oxon; CVD; cardiovascular disease; EDTA; ethylenediamine tetraacetetic acid; F