Keywords: MCAO، انسداد شریان مغزی میانی; ACA, anterior cerebral artery; MCA, middle cerebral artery; PCA, posterior cerebral artery; ICA, internal carotid artery; ECA, external carotid artery; VA, vertebral artery; BA, basilar artery; MCAo, middle cerebral artery occlusion; pMCAo, permanent midd
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Keywords: MCAO، انسداد شریان مغزی میانی; MK, midkine; MCAO, middle cerebral artery occlusion; CCA, common carotid artery; ECA, external carotid artery; ICA, internal carotid artery; TTC, 2,3,5-triphenyltetrazorlium chloride; NT, nitrotyrosinePreconditioning exercise; Stroke; Neuroprotection; Mid
Keywords: MCAO، انسداد شریان مغزی میانی; HI, hypoxia–ischemia; HIE, hypoxic-ischemic encephalopathy; LAMP2, lysosome-associated membrane protein 2; LC3BI/II, microtubule-associated proteins 1A/1B light chain 3B; MCAO, middle cerebral artery occlusion; MQC, mitochondrial quality control; PN, post
Keywords: MCAO، انسداد شریان مغزی میانی; EtOH, ethanol; Glut1, glucose transporter 1; Glut3, glucose transporter 3; LDH, lactate dehydrogenase; MCA, middle cerebral artery; MCAO, middle cerebral artery occlusion; NBO, normobaric oxygen; PFK-1, phosphofructokinase1; rCBF, regional cerebral blood
Keywords: MCAO، انسداد شریان مغزی میانی; EDTA, ethylenediaminetetraacetic acid; MCAO, middle cerebral artery occlusion; MCTs, monocarboxylate transporters; PBS, phosphate-buffered saline; rCBF, regional cerebral blood flow; TBS, Tris-Buffered-Salineastrocyte; neuron; microvessel; monocarboxylate
Keywords: MCAO، انسداد شریان مغزی میانی; NBO, normobaric hyperoxia; pO2, pressure of oxygen; TPEN, N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine; MCAO, middle cerebral artery occlusion; TTC, 2,3,5-triphenyltetrazolium chloride; DMSO, dimethyl sulfoxide; NG, Newport Green; MTG, Mito Tracker
Keywords: MCAO، انسداد شریان مغزی میانی; RSSW, a standardized extract of RenSheng ShouWu; CNS, central nervous system; MCAO, middle cerebral artery occlusion; 4-VO, four-vessel occlusion; I/R, ischemia and reperfusion; AD, Alzheimer׳s disease; ROS, reactive oxygen species; MTT, 3-(4,5-dimethyl-t
Keywords: MCAO، انسداد شریان مغزی میانی; MCAO, middle cerebral artery occlusion; EA, ellagic acid; TTC, 2,3,5-triphenyltetrazolium chloride; MDA, malondialdehyde; LDH, lactate dehydrogenase; SOD, superoxide dismutase; MCA, middle cerebral artery; BBB, blood brain barrierAnimal model; Ellagic aci
Keywords: MCAO، انسداد شریان مغزی میانی; AP, alkaline phosphatase; MCAO, middle cerebral artery occlusion; NCCa-ATP channel, Ca2+-activated; [ATP]i, sensitive nonspecific cationchanne1; PBS, Phosphate-buffered saline; RT-PCR, reverse transcription-polymerase chain reaction; SUR, sulfonylurea rec
Keywords: MCAO، انسداد شریان مغزی میانی; SVZ, subventricular zone; MCAO, middle cerebral artery occlusion; NSCs, neural stem cells; RMS, rostral migratory stream; DG, dentate gyrus; OB, olfactory bulb; GFAP, glial fibrillary acidic protein; DCX, doublecortinSubventricular zone; Neurogenesis; Str
Keywords: MCAO، انسداد شریان مغزی میانی; BR, bradykinin; DG, dentate gyrus; CA1, cornu Ammonis 1 layer of hippocampus; CAT, catalase; FJ B, Fluoro-Jade B; MCA, middle cerebral artery; MCAO, middle cerebral artery occlusion; SOD, superoxide dismutase; CuZnSOD, copper–zinc dependent superoxide dis
Keywords: MCAO، انسداد شریان مغزی میانی; CKLF1, chemokine-like factor 1; MCAO, middle cerebral artery occlusion; TTC, 2,3,5-triphenyltetrazolium chloride; 18F-FDG, 18F-Ffluorodeoxy-d-glucose; PET, positron emission tomography; P-Akt, phosphorylated Akt; Bcl-2, B cell lymphoma-2 protein; Bax, Bcl
Keywords: MCAO، انسداد شریان مغزی میانی; ANOVA, analysis of variance; Bdnf, brain-derived neurotrophic factor; CUMS, chronic unpredictable mild stress; GABA, γ-aminobutyric acid; FST, forced swim test; MCAo, middle cerebral artery occlusion; Npas4, neuronal PAS domain-containing protein 4; OFT,
Keywords: MCAO، انسداد شریان مغزی میانی; 4-VO, 4-vessel occlusion; ACSF, artificial cerebrospinal fluid; BSA, bovine serum albumin; ECL, enhanced chemiluminescence; HRP, horseradish peroxidase; IA, A-type K+ currents; Kv, voltage-dependent K+ currents; MCAO, middle cerebral artery occlusion; PBS
Icariside II protects against cerebral ischemia–reperfusion injury in rats via nuclear factor-κB inhibition and peroxisome proliferator-activated receptor up-regulation
Keywords: MCAO، انسداد شریان مغزی میانی; Icariside II; Cerebral ischemia; Inflammation; Peroxisome proliferator-activated receptor; Nuclear factor κBIRS, Icariside II; MCAO, middle cerebral artery occlusion; IL-1β, interleukin-1β; TGF-β1, transforming growth factor-β1; IκB, inhibitory κB; NF-κB,
Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke
Keywords: MCAO، انسداد شریان مغزی میانی; Epigenetics; Stroke; Neuronal repairHDAC, histone deacetylase; MCAO, middle cerebral artery occlusion; SAHA, suberoylanilide hydroxamic acid; pNFH, phosphorylated neurofilament heavy chain; MBP, myelin basic protein; CREB, cAMP responsive element binding
Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats
Keywords: MCAO، انسداد شریان مغزی میانی; BBB, blood–brain barrier; BMSCs, bone marrow stromal cells; DM, diabetes mellitus; HMGB1, high-mobility group box 1; MCAo, middle cerebral artery occlusion; mNSS, modified neurological severity score; OGD, oxygen glucose deprivation; PBS, phosphate-buffer
The aqueous extract of rhizome of Gastrodia elata Blume attenuates locomotor defect and inflammation after traumatic brain injury in rats
Keywords: MCAO، انسداد شریان مغزی میانی; CSF, Cerebrospinal fluid; CCI, Controlled cortical impact; COX, Cyclooxygenase; GE, Gastrodia elata Blume; IL-6, Interleukin-6; LPS, Lipopolysaccharide; MCAO, Middle cerebral artery occlusion; NO, Nitric oxide; OGD, Oxygen-glucose deprivation; TBI, Trauma
Glibenclamide enhances the effects of delayed hypothermia after experimental stroke in rats
Keywords: MCAO، انسداد شریان مغزی میانی; HT, hypothermia; MCAO, middle cerebral artery occlusion; SUR1, Sulfonylurea receptor 1; COX-2, cyclooxygenase 2; TNF-α, tumor necrosis factor alpha; IL-1β, interleukin-1 beta; BBB, blood brain barrier; CNS, central nervous system; SUR1-TRPM4, Sulfonylurea
Post-ischemic treatment of WIB801C, standardized Cordyceps extract, reduces cerebral ischemic injury via inhibition of inflammatory cell migration
Keywords: MCAO، انسداد شریان مغزی میانی; A3AR, A3 adenosine receptor; APP, amyloid precursor protein; BBB, blood-brain barrier; CBF, cerebral blood flow; EB, evans blue; MBP, myelin basic protein; MCAO, middle cerebral artery Occlusion; MCP-1, monocyte chemoattractant protein-1; PFA, paraformald
Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat
Keywords: MCAO، انسداد شریان مغزی میانی; AL, Ad libitum; CR, caloric restriction; SIRT1, Sirtuin 1; NAD, nicotinamide adenine dinucleotide; MCAO, middle cerebral artery occlusion; siRNA, small interfering RNA; scr RNA, scrambled control RNA; CBF, cerebral blood flow; TTC, 2,3,5-triphenyltetrazol
Recombinant T-cell receptor ligand RTL1000 limits inflammation and decreases infarct size after experimental ischemic stroke in middle-aged mice
Keywords: MCAO، انسداد شریان مغزی میانی; CBF, cortical blood flow; CCA, common carotid artery; ECA, external carotid artery; MCA, middle cerebral artery; MCAO, middle cerebral artery occlusion; MHC, major histocompatibility complex; MOG, myelin oligodendrocyte glycoprotein; RTL1000, recombinant
Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke
Keywords: MCAO، انسداد شریان مغزی میانی; CNS, central nervous system; ECM, extracellular matrix; MCAO, middle cerebral artery occlusion; PDGFRβ, platelet-derived growth factor receptor βCollagen; Extracellular matrix; Fibroblast; Fibronectin; Fibrosis; Ischemic stroke; Pericyte; Platelet-derived
Internalization of GluA2 and the underlying mechanisms of cognitive decline in aged rats following surgery and prolonged exposure to sevoflurane
Keywords: MCAO، انسداد شریان مغزی میانی; PI3K, phosphoinositide-3-kinase; MCAO, middle cerebral artery occlusion; AMPAR, a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; GluA2, glutamate receptor subunit 2; MEF2, Myocyte enhancer factor 2; Arc, activity-regulated cytoskeleton-assoc
Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia
Keywords: MCAO، انسداد شریان مغزی میانی; BrdU, 5-bromo-2′-deoxyuridine; CNS, central nervous system; DCX, doublecortin; E2, 17β-estradiol; ER, estrogen receptor; MCAO, middle cerebral artery occlusion; NPCs, neural progenitor cells; PBS, phosphate buffered saline; SERM, selective estrogen recept
Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK
Keywords: MCAO، انسداد شریان مغزی میانی; ACSF, artificial cerebro-spinal fluid; AMPK, adenosine 5′-monophosphate (AMP)-activated protein kinase; ER stress, endoplasmic reticulum stress; MCAO, middle cerebral artery occlusion; ROS, reactive oxygen species; TG, thapsigargin; TTC, 2,3,5-triphenylte
Inhibition of thioredoxin-1 with siRNA exacerbates apoptosis by activating the ASK1-JNK/p38 pathway in brain of a stroke model rats
Keywords: MCAO، انسداد شریان مغزی میانی; Trx1, thioredoxin-1; MCAO, middle cerebral artery occlusion; I/R, ischemia/reperfusion; siRNA, small interfering RNA; ASK1, apoptosis signal-regulating kinase-1; P-ASK1, phosphorylation of apoptosis signal-regulating kinase-1; JNK, c-Jun N-terminal kinase
Isoflurane suppresses cortical spreading depolarizations compared to propofol — Implications for sedation of neurocritical care patients
Keywords: MCAO، انسداد شریان مغزی میانی; CSD, cortical spreading depression; ICU, intensive care unit; CBF, cerebral blood flow; MCAo, middle cerebral artery occlusion; DC, direct current; LSF, laser speckle flowmetry; ROI, region of interestIsoflurane; Propofol; Stroke; Cortical spreading depre
Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion through downregulation of aquaporin 4 expression
Keywords: MCAO، انسداد شریان مغزی میانی; ANOVA, analysis-of-variance; AQP4, aquaporin-4; BBB, blood–brain barrier; EB, Evans blue; MCAO, middle cerebral artery occlusion; OD, optical density; PCR, polymerase chain reaction; rt-PA, recombinant tissue plasminogen activatorStroke; Ginsenoside Rg1;
Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats
Keywords: MCAO، انسداد شریان مغزی میانی; I/R, ischemia/reperfusion; MCAO, middle cerebral artery occlusion; PI3K, phosphoinositide 3-kinases; GSK3β, glycogen synthase kinase 3β; TMP, Tetramethylpyrazine; TUNEL, transferase biotin-dUTP nick end labeling; NS, normal salineTetramethylpyrazine analo
Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
Keywords: MCAO، انسداد شریان مغزی میانی; Nrf2, nuclear factor erythroid 2-related factor 2; HO-1, heme oxygenase 1; SOD1, superoxide dismutase 1; MDA, malondialdehyde; I/R, ischemia/reperfusion; pMCAO, permanent middle cerebral artery occlusion; MCAO, middle cerebral artery occlusion; By, bicycl
Histone deacetylase expression in white matter oligodendrocytes after stroke
Keywords: MCAO، انسداد شریان مغزی میانی; Ac-HH, acetylated histone H; APC, adenomatous polyposis coli; BrdU, bromodeoxyuridine; DAPI, 4,6’-diamidino-2-phenylindole; HDAC, histone deacetylase; MBP, myelin basic protein; MCAO, middle cerebral artery occlusion; NG2, chondroitin sulfate proteoglycan
A dose–response study of thymosin β4 for the treatment of acute stroke
Keywords: MCAO، انسداد شریان مغزی میانی; Tβ4, thymosin beta 4; EAE, experimental autoimmune encephalomyelitis; OPCs, oligodendrocyte progenitor cells; SVZ, subventricular zone; MCAo, middle cerebral artery occlusion; OL, mature oligodendrocytes; rt-PA, recombinant tissue plasminogen activator; C
Social isolation after stroke leads to depressive-like behavior and decreased BDNF levels in mice
Keywords: MCAO، انسداد شریان مغزی میانی; MCAO, middle cerebral artery occlusion; ST, stroke surgery; SH, sham surgery; BDNF, Brain Derived Neurotrophic Factor; SI or ISO, social isolation; PH, pair-housed; PSD, post-stroke depression; PSA, post-stroke anxietySocial isolation; Middle cerebral art
PTEN degradation after ischemic stroke: A double-edged sword
Keywords: MCAO، انسداد شریان مغزی میانی; ACSF, artificial cerebral-spinal fluid; DMEM, Dulbecco modified Eagle medium; EGTA, ethylene glycol tetraacetic acid; FBS, fetal bovine serum; HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; MCAO, middle cerebral artery occlusion; NEM, N-ethylm
IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice
Keywords: MCAO، انسداد شریان مغزی میانی; I/R, ischemia/reperfusion; ICV, intracerebroventricle; IL-17A, interleukin (IL)-17A; mAb, monoclonal antibody; MCAO, middle cerebral artery occlusion; MS, multiple sclerosis; rIL-17A, recombinant mouse-IL-17A; RT-PCR, real-time PCR; SBDP145, aII-spectrin
Pre-ischemic treadmill training alleviates brain damage via GLT-1-mediated signal pathway after ischemic stroke in rats
Keywords: MCAO، انسداد شریان مغزی میانی; CCA, common carotid artery; DW, dry weight; EAAT, excitatory amino acids transporter; ECA, external carotid artery; ERK1/2, event-related kinase 1/2; ICA, internal carotid artery; MCA, middle cerebral artery; MCAO, middle cerebral artery occlusion; mGluR5
Motor skills training promotes motor functional recovery and induces synaptogenesis in the motor cortex and striatum after intracerebral hemorrhage in rats
Keywords: MCAO، انسداد شریان مغزی میانی; ICH, intracerebral hemorrhage; ADL, activities of daily living; CIMT, constraint-induced movement therapy; CNS, central nervous system; MST, motor skills training; MCAO, middle cerebral artery occlusion; PSD, postsynaptic density; MDS, motor deficit score
Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke
Keywords: MCAO، انسداد شریان مغزی میانی; ANOVA, analysis of variance; CBF, cerebral blood flow; GDNF, glial cell line-derived neurotrophic factor; HIE, hypoxic–ischemic encephalopathy; hUCB, human umbilical cord blood; HuNu, anti-human nuclei antibody; MCAO, middle cerebral artery occlusion; MNC
Impact of microRNA-134 on neural cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by targeting HSPA12B
Keywords: MCAO، انسداد شریان مغزی میانی; miRNAs, MicroRNAs; MCAO, Middle cerebral artery occlusion; OGD, Oxygen glucose deprivation; siRNAs, Short interfering RNAs; HSPA12B, Heat shock protein A12B; HSPA5, Heat shock protein A5; N2A, Mouse neuroblastoma N2a cells; MTT, 3-(4,5-Dimethylthiazol-2-y
Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway
Keywords: MCAO، انسداد شریان مغزی میانی; CCA, common carotid artery; ECA, external carotid artery; H/I, hypoxic/ischemic; HIE, hypoxia/ischemia encephalopathy; I/R, ischemia/reperfusion; MCAO, middle cerebral artery occlusion; TTC, 2,3,5-triphenyltetrazolium chlorideApelin-36; PI3K/Akt; Cerebral
Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance
Keywords: MCAO، انسداد شریان مغزی میانی; BBB, blood-brain barrier; CBF, cerebral blood flow; EB, Evans Blue dye; HLV, hemispheric lesion volume; HPC, hypoxic preconditioning; HT, hemorrhagic transformation; IL-6, interleukin-6; LDF, laser Doppler flow; MCAO, middle cerebral artery occlusion; STC
Nitrogen dioxide (NO2) pollution as a potential risk factor for developing vascular dementia and its synaptic mechanisms
Keywords: MCAO، انسداد شریان مغزی میانی; NO2, Nitrogen dioxide; VaD, Vascular dementia; TEM, Transmission electron microscope; MCAO, Middle cerebral artery occlusion; SYP, Synaptophysin; PSD-95, Postsynaptic density protein 95; LTP, Long-term potentiation; CVD, Cerebrovascular disease; AMPA, α-a
Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion
Keywords: MCAO، انسداد شریان مغزی میانی; ATF4, activating transcription factor 4; CAST, calpastatin; CHOP, C/EBP homologous protein; CPN, calpain; eif, eukaryotic initiation factor; MCAO, middle cerebral artery occlusion; MetAP2, methionine aminopeptidase 2; PERK, PKR-like endoplasmic reticulum
Low-speed treadmill running exercise improves memory function after transient middle cerebral artery occlusion in rats
Keywords: MCAO، انسداد شریان مغزی میانی; MCAO, middle cerebral artery occlusion; MAP2, microtubule-associated protein 2; BDNF, brain-derived neurotrophic factor; Low-Ex, low-intensity treadmill exercise; High-Ex, high-intensity treadmill exercise; Non-Ex, non-exercised; CCA, common carotid arter
Alpha-linolenic acid: A promising nutraceutical for the prevention of stroke
Keywords: MCAO، انسداد شریان مغزی میانی; ALA, alpha linolenic acid; ANSES, Agence Nationale pour la Sécurité et la Santé; BDNF, Brain Derived Neurotrophic Factor; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; LA, linoleic acid; MCAO, middle cerebral artery occlusion; PUFA, polyunsaturat
Neuroprotective effect of agmatine in rats with transient cerebral ischemia using MR imaging and histopathologic evaluation
Keywords: MCAO، انسداد شریان مغزی میانی; MCAO, middle cerebral artery occlusion; MRI, magnetic resonance imaging; T2WI, T2-weighted images; DWI, diffusion-weighted images; ADC, apparent diffusion coefficient; CE-T1WI, contrast-enhanced T1-weighted images; TTC, triphenyltetrazolium chloride; BBB,
Activation of estrogen receptor β reduces blood–brain barrier breakdown following ischemic injury
Keywords: MCAO، انسداد شریان مغزی میانی; ANOVA, analysis of variance; AQP4, aquaporin 4; BBB, Blood–brain barrier; CBF, cerebral blood flow; DPN, diarylpropionitrile; ERs, estrogen receptors; HIF-1α, hypoxia-inducible factor 1α; IgG, immunoglobulin G; MCAO, middle cerebral artery occlusion; MMPs
Post-stroke infections exacerbate ischemic brain injury in middle-aged rats: Immunomodulation and neuroprotection by progesterone
Keywords: MCAO، انسداد شریان مغزی میانی; ANOVA, analysis of variance; BDNF, brain-derived neurotrophic factor; CBF, cerebral blood flow; HPA, hypothalamo–pituitary–adrenal; IL-1β, interleukin-1β; IL-6, interleukin-6; LPS, lipopolysaccharide; MCAO, middle cerebral artery occlusion; P4, progestero
Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate
Keywords: MCAO، انسداد شریان مغزی میانی; BSA, bovine serum albumin; cdk5, cyclin-dependent kinase 5; cGMP, cyclic guanosine monophosphate; Cyt c, cytochrome c; DG, dentate gyrus; LDH, lactate dehydrogenase; MCAo, middle cerebral artery occlusion; MDL28170, carbobenzoxy-valinyl-phenyl-alaninal; M