Keywords: مهار مبتنی بر مکانیسم; Myeloperoxidase; Neutrophils; Oxidative stress; Suicide inhibitor; Mechanism-based inhibition; Oxidative modification;
مقالات ISI مهار مبتنی بر مکانیسم (ترجمه نشده)
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Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach
Keywords: مهار مبتنی بر مکانیسم; Cytochrome P450; Drug-drug interactions; Degradation rate constant; Human hepatocytes; Mechanism-based inhibition; Physiologically-based pharmacokinetic modelling; Small-interfering RNA; Half-life; Time-dependent inhibition;
Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation
Keywords: مهار مبتنی بر مکانیسم; Cytochrome P450 2D6; Methylenedioxyphenyl compounds; Time-dependent inhibition; 3,4-methylenedioxymethamphetamine; Mechanism-based inhibition;
Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method
Keywords: مهار مبتنی بر مکانیسم; bioavailability; cytochrome P450; drug interaction; dynamic simulation; first pass metabolism; hepatic clearance; intestinal metabolism; pharmacokinetics; simulations; parallel tube model; Ae (Ae,oral); dose fractions of urinary excreted unchanged drug af
Imidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes
Keywords: مهار مبتنی بر مکانیسم; Antitumor agent; C-1311; Drug–drug interactions; Cytochrome P450 isoenzymes; Mechanism-based inhibition
Underlying mechanism of drug–drug interaction between pioglitazone and gemfibrozil: Gemfibrozil acyl-glucuronide is a mechanism-based inhibitor of CYP2C8
Keywords: مهار مبتنی بر مکانیسم; Gemfibrozil; Pioglitazone; Mechanism-based inhibition; Acyl-glucuronide; CYP2C8UGT, UDP-glucuronosyltransferase; HPLC, high performance liquid chromatography; CYP, cytochrome P450; AUC, area under the concentration/time curve; HLM, human liver microsomes;
Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2
Keywords: مهار مبتنی بر مکانیسم; MBI; mechanism-based inhibition; RMs; reactive metabolites; CYPs; cytochrome P450 enzymes; GSH; reduced glutathione; HLMs; human liver microsomes; NADPH; β-nicotinamide adenine dinucleotide 2'-phosphate reduced tetrasodium salt; MI complex; metabolite
Identification and characterization of potent CYP2D6 inhibitors in lotus leaves
Keywords: مهار مبتنی بر مکانیسم; Nelumbo nucifera; Cytochrome P450; Herb–drug interactions; Mechanism-based inhibition
Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol
Keywords: مهار مبتنی بر مکانیسم; CBD, cannabidiol; CBDHQ, CBD-hydroxyquinone; CBDM, CBD-2′-monomethyl ether; CBDD, CBD-2′,6′-dimethyl ether; CBDV, cannabidivarin; CYP, cytochrome P450; EROD, 7-ethoxyresorufin O-deethylaseCannabidiol; CYP1A1; Inactivation; Mechanism-based inhibition; Stru
Mechanism-based Inactivation of Cytochrome P450 2A6 and 2A13 by Rhinacanthus nasutus Constituents
Keywords: مهار مبتنی بر مکانیسم; CYP2A; human CYP enzymes; mechanism-based inhibition; NADPH cytochrome P450 reductase
Assessment of drug–drug interactions caused by metabolism-dependent cytochrome P450 inhibition
Keywords: مهار مبتنی بر مکانیسم; Metabolism-dependent inhibition; Mechanism-based inhibition; Reactive metabolites; Drug–drug interaction; Cytochrome P450; Reversibility
A mechanism based protein crosslinker for acyl carrier protein dehydratases
Keywords: مهار مبتنی بر مکانیسم; Mechanism-based inhibition; Polyketide biosynthesis; Fatty acid biosynthesis; Dehydratase; Protein–protein interaction
Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-c
Keywords: مهار مبتنی بر مکانیسم; Multiple drug–drug interactions; Metabolite kinetics; Mechanism-based inhibition; Simulation; Diltiazem
Echinacea metabolism and drug interactions: The case for standardization of a complementary medicine
Keywords: مهار مبتنی بر مکانیسم; Echinacea; Alkylamides; Alkamides; Isobutylamides; Cytochrome P450; Drug interactions; Herbal medicines; Mechanism-based inhibition
Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition
Keywords: مهار مبتنی بر مکانیسم; Mechanism-based inhibition; Enzyme inactivation; Drug interactions; Simulation; Genetic algorithm
Inhibition of CYP2B4 by the mechanism-based inhibitor 2-ethynylnaphthalene: Inhibitory potential of 2EN is dependent on the size of the substrate
Keywords: مهار مبتنی بر مکانیسم; Cytochrome P450; CYP2B4; Mechanism-based inhibition; Enzyme kinetics; 2-Ethynylnaphthalene
Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants
Keywords: مهار مبتنی بر مکانیسم; CYP, cytochrome P450; CYP3A4, cytochrome P450 3A4; CYP2D6, cytochrome P450 2D6; NADPH, nicotinamide adenine dinucleotide phosphate; HLM, human liver microsomesIndonesian medicinal plants; Mechanism-based inhibition; Cytochrome P450; CYP3A4; CYP2D6
Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs
Keywords: مهار مبتنی بر مکانیسم; Sulfatase; Inhibition; Mechanism-based inhibition; Proteomics
Kinetic values for mechanism-based enzyme inhibition: Assessing the bias introduced by the conventional experimental protocol
Keywords: مهار مبتنی بر مکانیسم; Mechanism-based inhibition; Enzyme inactivation; Drug-drug interactions; Simulation;
Metabolite-cytochrome P450 complex formation by methylenedioxyphenyl lignans of Piper cubeba: Mechanism-based inhibition
Keywords: مهار مبتنی بر مکانیسم; Piper cubeba; Indonesian medicinal plant; (–)-Clusin; (–)-Dihydroclusin; Mechanism-based inhibition; CYP3A4; Methylenedioxyphenyl lignan
Mechanism-Based Inactivation of Human Liver Microsomal CYP3A4 by Rutaecarpine and Limonin from Evodia Fruit Extract
Keywords: مهار مبتنی بر مکانیسم; Herbal medicines; Evodia fruit; CYP3A4; mechanism-based inhibition; inactivation;