Role of extracellular matrix and YAP/TAZ in cell fate determination
Keywords: مکانیک انتقال; Extracellular matrix; Mechanotransduction; Hippo signaling; Wnt; YAP/TAZ;
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Matrix rigidity regulates spatiotemporal dynamics of Cdc42 activity and vacuole formation kinetics of endothelial colony forming cells
Keywords: مکانیک انتقال; Endothelial colony forming cells (ECFCs); Rho family GTPases; Fluorescence resonance energy transfer (FRET); Live cell imaging; Matrix stiffness; Mechanotransduction;
Integrin αv in the mechanical response of osteoblast lineage cells
Keywords: مکانیک انتقال; Osteoblast; Integrin αv; Mechanotransduction; p130Cas; YAP/TAZ;
Vascular analysis as a proxy for mechanostransduction response in an isogenic, irradiated murine model of mandibular distraction osteogenesis
Keywords: مکانیک انتقال; Head and neck cancer; Distraction osteogenesis; Tissue engineering; Vasculogenesis; Angiogenesis; Radiation therapy; Mechanotransduction; Isogenic
Ovariectomy enhances mechanical load-induced solute transport around osteocytes in rat cancellous bone
Keywords: مکانیک انتقال; Osteoporosis; Osteocyte; Canaliculi; Interstitial fluid; Perilacunar remodeling; Mechanotransduction;
Maintenance of undifferentiated state of human induced pluripotent stem cells through cytoskeleton-driven force acting to secreted fibronectin on a dendrimer-immobilized surface
Keywords: مکانیک انتقال; Human induced pluripotent stem cells; Undifferentiation; Mechanotransduction; Cell–cell interaction; Dendrimer surface
Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix
Keywords: مکانیک انتقال; Primary cilia; Finite element analysis; Mechanotransduction; Tensile strain; Ciliary membrane; Mechanobiology; Ciliary pocket; Adipose derived stem cells;
Temporal phosphoproteomics to investigate the mechanotransduction of vascular smooth muscle cells in response to cyclic stretch
Keywords: مکانیک انتقال; Vascular smooth muscle cells; Mechanotransduction; Phosphoproteomics; Cyclic stretch
Candidate mediators of chondrocyte mechanotransduction via targeted and untargeted metabolomic measurements
Keywords: مکانیک انتقال; Chondrocyte; Osteoarthritis; Mechanotransduction; Metabolomics; Joint biology; Cartilage
The structure and function of the pericellular matrix of articular cartilage
Keywords: مکانیک انتقال; Chondron; Type II collagen; Type VI collagen; Perlecan; Aggrecan; Osteoarthritis; Territorial matrix; Decorin; Mechanobiology; Mechanotransduction
Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4-MyD88 dissociation
Keywords: مکانیک انتقال; Chemokines; Lipopolysaccharide (LPS); Mechanotransduction; Osteoblasts; Toll-like receptors (TLR);
LIM proteins in actin cytoskeleton mechanoresponse
Keywords: مکانیک انتقال; mechanotransduction; stress fiber; zyxin; LIM domain; focal adhesion
A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons
Keywords: مکانیک انتقال; 3D culture; Self-assembling peptide; Alzheimer's disease; Mechanotransduction; iPSCs; Neuron;
Megakaryocytes are mechanically responsive and influence osteoblast proliferation and differentiation
Keywords: مکانیک انتقال; MK; megakaryocyte; LCM; laser capture microdissection; ECM; extracellular matrix; PMA; phorbol 12-myristate 13-acetate; UT; untouched; BGP; β-glycerophosphate; Osx; osterix; OCN; osteocalcin; BSP; bone sialoprotein; Megakaryocyte; Fluid shear; Mechanotra
Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats
Keywords: مکانیک انتقال; A fiber; C fiber; Electrophysiology; Hyperalgesia; Mechanotransduction; Nerve injury; Neuropathic; Nociceptor; Optogenetics; Pain; Sensory neuron; Withdrawal;
Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells
Keywords: مکانیک انتقال; Mechanotransduction; Flow; Bioenergetics; Fission; Peroxiredoxins;
Matrix density alters zyxin phosphorylation, which limits peripheral process formation and extension in endothelial cells invading 3D collagen matrices
Keywords: مکانیک انتقال; EC, endothelial cell; SDF, stromal-derived factor; TPA, phorbol ester; 3D, three-dimensional; VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor; S1P, sphingosine 1-phosphateCollagen; Matrix density; Angiogenesis; Mechanotransduction;
Involvement of N-cadherin/β-catenin interaction in the micro/nanotopography induced indirect mechanotransduction
Keywords: مکانیک انتقال; Micro/nanotopography; MC3T3-E1; Mechanotransduction; N-cadherin; β-catenin;
Sorting out a promiscuous superfamily: towards cadherin connectomics
Keywords: مکانیک انتقال; adhesion; neuronal connectivity; hearing; mechanotransduction; cancer; brain development.
Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy
Keywords: مکانیک انتقال; FRET; FLIM; FCS; Mechanotransduction; Paxillin; Focal adhesion kinase;
Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures
Keywords: مکانیک انتقال; CREB; cAMP response element binding protein; DMMB; dimethylmethylene blue; ECM; extracellular matrix; ERK; extracellular signal-regulated kinase; Epac; exchange protein directly regulated by cAMP; FBS; foetal bovine serum; GAG; glycosaminoglycan; HAS; hya
Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts
Keywords: مکانیک انتقال; Fluorescence resonance energy transfer (FRET); MC3T3-E1; Mechanical loading; Mechanotransduction; Rho family GTPases; TCF/LEF;
Focal adhesion kinase mediates β-catenin signaling in periodontal ligament cells
Keywords: مکانیک انتقال; Tooth movement; COX-2; Nitric oxide; Mechanotransduction; Akt signaling; Prostaglandin E2; β-catenin signaling; Periodontal ligament cell;
Mesenchymal stem cells ability to generate traction stress in response to substrate stiffness is modulated by the changing extracellular matrix composition of the heart during development
Keywords: مکانیک انتقال; Extracellular matrix; Mesenchymal stem cells; Traction stress; Mechanotransduction;
Shear stress-induced Ang II AT1 receptor activation: G-protein dependent and independent mechanisms
Keywords: مکانیک انتقال; Shear stress; Mechanotransduction; Ang II AT1 receptor; Cell signaling;
A genomics approach in determining nanotopographical effects on MSC phenotype
Keywords: مکانیک انتقال; Mesenchymal stem cells (MSCs); Nanotopography; Mechanotransduction; Gene expression; Cell signalling; Molecular biology;
Original Full Length ArticleRegulation of PTHrP expression by cyclic mechanical strain in postnatal growth plate chondrocytes
Keywords: مکانیک انتقال; Mechanical strain; Parathyroid hormone-related protein (PTHrP); Growth plate; Chondrocyte; F-actin; Mechanotransduction;
Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells
Keywords: مکانیک انتقال; trabecular meshwork; glaucoma; biophysical cues; substratum compliance; extracellular matrix; mechanotransduction;
Inactivation of Lrp5 in osteocytes reduces Young's modulus and responsiveness to the mechanical loading
Keywords: مکانیک انتقال; Lrp5; low-density-lipoprotein receptor-related protein 5; Dmp1; dentin matrix acidic phosphoprotein 1; Cre; Cre recombinase; BMD; bone mineral density; BMC; bone mineral content; Lrp5; Osteocytes; Mechanotransduction; Young's modulus; Osteoporosis;
Original Full Length ArticleCyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro
Keywords: مکانیک انتقال; Hydrostatic pressure; Bone development; Chick foetal femur; Mechanotransduction; Bioreactor; Dynamic pressure;
Beyond gap junctions: Connexin43 and bone cell signaling
Keywords: مکانیک انتقال; Connexin43; Osteoblast; Osteocyte; Apoptosis; Bisphosphonates; Mechanotransduction;
Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβ
Keywords: مکانیک انتقال; Strain; Mechanotransduction; Transforming Growth Factor β; Metalloproteinase; Tendon;
What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease
Keywords: مکانیک انتقال; biophysical cueing; mechanotransduction; YAP; TAZ; hippo; TGFβ; Wnt;
Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flow
Keywords: مکانیک انتقال; Osteocyte; Fluid flow; Mechanotransduction; Cytoskeleton
Gap junction and hemichannel functions in osteocytes
Keywords: مکانیک انتقال; Gap junctions; Hemichannels; Connexin 43; Osteocytes; Mechanotransduction
One load to rule them all: Mechanical control of the musculoskeletal system in development and aging
Keywords: مکانیک انتقال; Musculoskeletal system; Mechanobiology; Mechanoregulation; Mechanotransduction; Skeletogenesis
Mechanosensation and transduction in osteocytes
Keywords: مکانیک انتقال; Mechanosensation; Mechanotransduction; Osteocytes; Osteoblasts; Osteoclasts; Fluid flow
Emerging role of primary cilia as mechanosensors in osteocytes
Keywords: مکانیک انتقال; Bone; Mechanotransduction; Mechanosensation; Osteocytes; Primary cilia
Peyronie's Disease and Mechanotransduction: An In Vitro Analysis of the Cellular Changes to Peyronie's Disease in a Cell‐Culture Strain System
Keywords: مکانیک انتقال; Peyronie's Disease; Mechanotransduction; Penile Traction Therapy; Cellular Strain Model; Plaque Remodeling; Penile Curvature and Length
From tissue mechanics to transcription factors
Keywords: مکانیک انتقال; Mechanotransduction; Mechanosensing; Substrate stiffness; Mechanical stress
Neuronal differentiation on anisotropic substrates and the influence of nanotopographical noise on neurite contact guidance
Keywords: مکانیک انتقال; Mechanotransduction; Neurite; Focal adhesion; Cell contractility; Contact guidance; Noise
Integrating actin dynamics, mechanotransduction and integrin activation: The multiple functions of actin binding proteins in focal adhesions
Keywords: مکانیک انتقال; Actin; Mechanotransduction; Integrins; Focal adhesions
Perturbations of mechanotransduction and aneurysm formation in heritable aortopathies
Keywords: مکانیک انتقال; Aorta; Aneurysm; Mechanotransduction; Gene; Mutation
Mechanotherapy: revisiting physical therapy and recruiting mechanobiology for a new era in medicine
Keywords: مکانیک انتقال; mechanotherapy; mechanobiology; mechanotransduction; wound healing
Biological effects of cellular stretch on human dermal fibroblasts
Keywords: مکانیک انتقال; Pathological scars; Cellular stretching; Human dermal fibroblast; Mechanotransduction
Ultrasound can Modulate Neuronal Development: Impact on Neurite Growth and Cell Body Morphology
Keywords: مکانیک انتقال; Ultrasound; Neuronal development; Repulsive cue; Neurite retraction; Cell body shrinkage; Cell body displacement; Mechanotransduction;
Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions
Keywords: مکانیک انتقال; Actomyosin; Lung adenocarcinoma cell; NF-κB; Mechanotransduction; Substrate stiffness
Fluid flow forces and rhoA regulate fibrous development of the atrioventricular valves
Keywords: مکانیک انتقال; Cardiac development; RhoA signaling; Mechanotransduction; Fibrous development; Hemodynamics
Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering
Keywords: مکانیک انتقال; Tissue engineering; Stem cells; Nanomaterials; Scaffold; Bone tissue engineering; Cartilage tissue engineering; Neural engineering; Mechanotransduction; Surface characteristics; Stiffness
Blood flow and arterial endothelial dysfunction: Mechanisms and implications
Keywords: مکانیک انتقال; Endothelial cells; Atherosclerosis; Mechanotransduction; Cytoskeleton; Blood flow; MechanosensorsCellules endothéliales; Athérosclérose; Mécanotransduction; Cytosquelettte; Écoulement sanguin; Mécanosenseurs