CX3CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model
Keywords: Rett syndrome; MeCP2; Microglia; CX3CR1;
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Effects of chronic exposure to low dose THIP on brainstem neuronal excitability in mouse models of Rett syndrome: Evidence from symptomatic females
Keywords: Mecp2; Female mouse model; THIP; Electrophysiology; Neuronal excitability; Locus coeruleus;
Structural Basis of MeCP2 Distribution on Non-CpG Methylated and Hydroxymethylated DNA
Keywords: MeCP2; methyl-CpG binding protein 2; mCG; 5-methylcytosines in CpG; mCH; non-CG methylated sites; hmC; hydroxymethylcytosine; mCA; methylated CpA; hmCA; hydroxymethylated CpA; MBD; methyl-CpG-binding domain; ITC; isothermal titration calorimetry; CSP; che
A Potential Life-Threatening Reaction to Glatiramer Acetate in Rett Syndrome
Keywords: brain-derived neurotrophic factor (BDNF); immediate postinjection response (IPIR); MECP2; autonomic nervous system;
The L1 adhesion molecule normalizes neuritogenesis in Rett syndrome-derived neural precursor cells
Keywords: MeCP2; L1CAM; RTT syndrome; iPSCs; Neuritogenesis; RTT; Rett Syndrome; MeCP2; methyl-CpG-binding protein-2; iPSC; induced pluripotent stem cell; RTT NPC; RTT iPSC-derived neural precursorcell; TRE; tetracycline response element; CAG; chicken beta-actin pr
Functional integration of complex miRNA networks in central and peripheral lesion and axonal regeneration
Keywords: AAV(s); adeno-associated virus(es); ADAM; a disintegrin and metalloprotease; AGO(2); argonaut (2); AKT; protein kinase B; APC; adenomatous polyposis coli; ASO(s); antisense oligonucleotide(s); ATF3; activating transcription factor 3; BBB; blood brain barr
Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Keywords: CDKL5; DYRK1A; Protein phosphorylation; Rett syndrome; Down syndrome; Amph1; amphiphysin 1; CDKL5; cyclin-dependent kinase-like 5; Dnmt1; DNA methyltransferase 1; DYRK1A; dual specificity tyrosine-phosphorylation-regulated kinase 1A; GST; glutathione S-tr
Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis
Keywords: 24S-OHC; 24(S)-hydroxycholesterol; Apoe; apolipoprotein E; CNS; central nervous system; Cyp27a1; cholesterol 27-hydroxylase; Cyp46a1; cholesterol 24-hydroxylase; Hmgcr; 3-hydroxy-3-methylglutaryl-CoA reductase; Mecp2; methyl CpG-binding protein 2; SC4mol;
EZH2 regulates spinal neuroinflammation in rats with neuropathic pain
Keywords: EDTA; ethylenediaminetetraacetic acid; EZH2; enhancer of zeste homolog-2; H3K27; histone H3 on K27; H3K27TM; tri-methylated H3K27; MeCP2; methyl-CpG-binding protein 2; PRC2; polycomb complex 2; pSNL; partial sciatic nerve ligation; nociception; cytokine;
Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder (ASD) subjects
Keywords: 5fC; 5-formylcytosine; 5caC; 5-carboxycytosine; 5mC; 5-methylcytosine; 5hmC; 5-hydroxymethylcytosine; ACTB; b-actin; ASD; autism spectrum disorder; BA; Brodmann area; BDNF; brain derived neurotrophic factor; BDNF-IV; BDNF-promoter 4; BDNF-IX; BDNF-promote
Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization
Keywords: miRNA/miR; microRNA; MRTF; myocardin related transcription factor; SMC; smooth muscle cell; HCASMC; human coronary artery smooth muscle cell; mAoSMC; mouse aortic smooth muscle cell; G-actin; globular actin; F-actin; filamentous actin; SRF; serum response
Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST)
Keywords: ENCODE; encyclopedia of DNA elements; HDAC; histone deacetylase; MeCP2; methyl CpG binding protein 2; miRNA; micro-RNA; NRSF; neuron-restrictive silencing factor; REST; repressor element-1 silencing transcription; Epigenetics; Neuropathic pain; NRSF/REST;
In silico analysis of nsSNPs in human methyl CpG binding protein 2
Keywords: MECP2; methyl CpG binding protein 2; SNP; single nucleotide polymorphism; SIFT; sorting intolerant from tolerant; PolyPhen; phenotype polymorphism; nsSNP; non synonymous single nucleotide polymorphism; OMIM; online Mendelian inheritance in man; MUSTER; mu
Caretaker Quality of Life in Rett Syndrome: Disorder Features and Psychological Predictors
Keywords: Rett syndrome; MECP2; SF-36v2; ANCOVA; general linear model
Melatonin treatment during the incubation of sensitization attenuates methamphetamine-induced locomotor sensitization and MeCP2 expression
Keywords: Melatonin; Methamphetamine; Incubation; Sensitization; Nucleus accumbens; MeCP2;
OxInflammation in Rett syndrome
Keywords: Rett syndrome; MECP2; Oxidative stress; Inflammation; Cytokines;
Research ArticleHepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape
Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; aHSC; activated hepatic stellate cells; ALD; alcoholic liver disease; DNMT; DNA methyltransferase; HSC; hepatic stellate cells; MeCP2; methyl-CpG binding protein 2; NHL; normal human liver; PSC; prim
Original ArticlesPhenotype Differentiation of FOXG1 and MECP2 Disorders: A New Method for Characterization of Developmental Encephalopathies
Keywords: FOXG1; MECP2; developmental encephalopathy; autism; intellectual disability; quantitative phenotyping; natural history; DEI; Developmental Encephalopathy Inventory;
The impact of next-generation sequencing on the DNA methylation-based translational cancer research
Keywords: BS; bisulfite sequencing; DMR; differentially methylated region; HGOSC; high-grade ovarian serous carcinoma; MBD; methyl-binding domain; 5-mC; 5-methylcytosine; MeCP2; methyl CpG binding protein 2; NGS; next-generation sequencing; NSCLC; non-small cell lu
Expression of nuclear Methyl-CpG binding protein 2 (Mecp2) is dependent on neuronal stimulation and application of Insulin-like growth factor 1
Keywords: Mecp2; MethylCpG-binding protein 2; IGF1; insulin-like growth factor 1; Activity-dependent plasticity; Rett syndrome; Feedforward and feedback mechanisms of plasticity; Insulin-like growth factor 1 (IGF1);
Rett Syndrome Turns 50: Themes From a Chronicle
Keywords: Rett syndrome; life story; history of neurology; MECP2; humanism;
MECP2 impairs neuronal structure by regulating KIBRA
Keywords: MECP2; Methyl-CpG-binding protein 2; RTT; Rett syndrome; MDS; MECP2 duplication syndrome; hMECP2; human MECP2; 5â²Mc; 5-mehtylcytosine; MBD; methyl binding domain; hR106W; human MECP2 variant R106W; qRT-PCR; quantitative real-time polymerase chain reacti
Prenatal stress and early life febrile convulsions compromise hippocampal genes MeCP2/REST function in mid-adolescent life of Sprague-Dawley rats
Keywords: Prenatal stress; Febrile seizures; Epigenetics; MeCP2; REST; Cognitive function;
Applying the ethoexperimental approach to neurodevelopmental syndrome research reveals exaggerated defensive behavior in Mecp2 mutant mice
Keywords: MECP2; Rett syndrome; Ethoexperimental approach; Autism; Defense; Fear
Methyl CpG binding protein 2 deficiency enhances expression of inflammatory cytokines by sustaining NF-κB signaling in myeloid derived cells
Keywords: NF-κB; MeCP2; TNFα; Peripheral blood mononuclear cells; p65; Acetylated histone;
Age of Diagnosis in Rett Syndrome: Patterns of Recognition Among Diagnosticians and Risk Factors for Late Diagnosis
Keywords: Rett syndrome; MECP2; early diagnosis; risk factors; prognosis;
Is it possible to diagnose Rett syndrome before classical symptoms become obvious? Review of 24 Danish cases born between 2003 and 2012
Keywords: Rett syndrome (RTT); MECP2; Regression; Intellectual disability (ID); Early diagnosis; Symptoms
Geniposide alleviates inflammation by suppressing MeCP2 in mice with carbon tetrachloride-induced acute liver injury and LPS-treated THP-1 cells
Keywords: Geniposide (GP); Acute liver injury (ALI); Inflammation; MeCP2; Hedgehog pathway (Hh);
Perinatal nicotine exposure suppresses PPARγ epigenetically in lung alveolar interstitial fibroblasts
Keywords: α-SMA; Alpha smooth muscle actin; ATII; Alveolar epithelial type II; Aza-CdR; 5-Aza-2â²-deoxycytidine; ChIP; Chromatin immunoprecipitation; DMSO; Dimethyl sulfoxide; DNMT1; DNA methyltransferase 1; LIFs; Lipofibroblasts; MSP; Methylation-specific-PCR; M
Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome
Keywords: Mecp2; Auditory processing; Speech therapy; Plasticity; Rett syndrome; Cortex;
MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells
Keywords: iPS cell disease models; Rett syndrome; MeCP2;
ReviewSchizophrenia: Evidence implicating hippocampal GluN2B protein and REST epigenetics in psychosis pathophysiology
Keywords: BDP; psychotic bipolar disorder; CK1; casein kinase 1; DG; dentate gyrus; HC; healthy controls; HDACs; histone deacetylases; MeCP2; methyl CpG binding protein 2; MR; magnetic resonance; NMDA; N-methyl-d-aspartate; NMDAR; NMDA receptor; PcG; polycomb group
Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala
Keywords: Amygdala; Gadd45b; Methylation; Epigenetics; Social play; Reelin; MeCP2; Adra2a; Cytokines; Development;
Specificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2
Keywords: Autoantibodies; Autoimmunity; Dense fine speckles; DFS70; LEDGFp75; MeCP2;
Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder
Keywords: CDKL5; cyclin-dependent kinase-like 5; GCLC; glutamate-cysteine ligase catalytic subunit; HNE; 4-hydroxy-2-nonenal; HNE-PA; HNE-protein adduct; iNOS; inducible NO synthase; MECP2; methyl-CpG binding protein 2; Nrf2; nuclear factor erythroid 2-relate
Bases moleculares del síndrome de Rett, una mirada actual
Keywords: Síndrome de Rett; MECP2; CDKL5; FOXG1; Trastorno del neurodesarrollo; Epilepsia precozRett syndrome; MECP2; CDKL5; FOXG1; Neurodevelopmental disorder; Early epilepsy
Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT
Keywords: Circadian rhythms; MeCP2; Rett syndrome (RTT); Sleep; Suprachiasmatic nucleus (SCN); VIP
VEGF overexpression enhances the accumulation of phospho-S292 MeCP2 in reactive astrocytes in the adult rat striatum following cerebral ischemia
Keywords: VEGF; vascular endothelial growth factor; MeCP2; methyl-CpG-binding protein 2; pS292; phospho-serine 292; NSCs; neural stem cells; BBB; blood-brain barrier; MCAO; middle cerebral artery occlusion; RTT; Rett syndrome; PPTase; alkaline phosphatase; phVEGF
Epigenetics of idiopathic pulmonary fibrosis
Keywords: α-SMA; α-smooth muscle actin; DNMT; DNA methyltransferase; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; HDAC; histone deacetylase; IPF; idiopathic pulmonary fibrosis; MeCP2; methyl CpG binding protein 2; miRNA; micro-RNA; MMP; matr
Ethanol deregulates Mecp2/MeCP2 in differentiating neural stem cells via interplay between 5-methylcytosine and 5-hydroxymethylcytosine at the Mecp2 regulatory elements
Keywords: 5hmC; 5-hydroxymethylcytosine; 5mC; 5-methylcytosine; bFGF; basic fibroblast growth factor; Ct; threshold cycle values; DAPI; 4â²,6-diamidino-2-phenylindole; D; day; DMEM/F12; Dulbecco's Modified Eagle Medium: Nutrient Mixture F-12; E; embryonic day; EDT
Prenatal diagnosis of foetuses with congenital abnormalities and duplication of the MECP2 region
Keywords: MECP2; the methyl CpG binding protein 2; XCI; X-chromosome inactivation; CMA; Chromosome microarray analysis; FGR; foetal growth restriction; CVS; chorionic villus sampling; AF; amniocentesis; RT-PCR; real-time polymerase chain reaction; VM; ventriculomeg
Novel mutation in Forkhead box G1 (FOXG1) gene in an Indian patient with Rett syndrome
Keywords: RTT, Rett syndrome; MECP2, Methyl CpG Binding Protein 2; CDKL5, Cyclin Dependent Protein Kinase like 5; FOXG1, Forkhead box G1Rett syndrome; FOXG1; Mutation; DNA sequencing; MECP2
DNA methylation in cardiac fibrosis: New advances and perspectives
Keywords: ECM; extracellular matrix; α-SMA; α-smooth muscle actin; EMT; epithelial to mesenchymal transition; ET-1; endothelin-1; DNMT; DNA methyltransferase; MeCP2; methyl-CpG-binding protein 2; MBD; methylcytosine-binding domains; miRNA; microRNAs; SAM; S-adeny
Genomic distribution and possible functions of DNA hydroxymethylation in the brain
Keywords: 5-Hydroxymethylcytosine; TET; DNA methylation; Active DNA demethylation; Brain; MeCP2
Late onset epileptic spasms is frequent in MECP2 gene duplication: Electroclinical features and long-term follow-up of 8 epilepsy patients
Keywords: MECP2; Epileptic spasms; Refractory epilepsy
Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome
Keywords: Rett syndrome; MECP2; Intellectual disability; Growth; Ghrelin; GH; IGF-1
Research ReportMeCP2 regulates GFAP expression within the developing brain
Keywords: MeCP2; GFAP; Development; Sex differences;
An increase in MECP2 dosage impairs neural tube formation
Keywords: Rett syndrome; MECP2; Chicken neurogenesis; Neuroblast proliferation;
MicroRNA-432 contributes to dopamine cocktail and retinoic acid induced differentiation of human neuroblastoma cells by targeting NESTIN and RCOR1 genes
Keywords: RA; retinoic acid; 3â²-UTR; 3â²-untranslated region; DAPI; 4â²,6-diamidino-2-phenylindole; DC; dopamine cocktail; MECP2; methyl CpG binding protein 2; RCOR1; co-repressor 1 or COREST; TUBB3; beta III-tubilin; NES; NESTIN; CNR1; cannabinoid receptor typ
BDNF deregulation in Rett syndrome
Keywords: BDNF; MeCP2; Rett syndrome; Intellectual disability; Mouse models;