Keywords: ترخیص متابولیک; clinical pharmacokinetics; distribution; hepatic clearance; in vitro-in vivo correlations (IVIVC); metabolic clearance; oral absorption; physiological model; preclinical pharmacokinetics; protein binding; simulations;
مقالات ISI ترخیص متابولیک (ترجمه نشده)
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Keywords: ترخیص متابولیک; CYP450; Metabolic clearance; Drug-drug interactions; Abiraterone; Enzalutamide; Prostate cancer;
Keywords: ترخیص متابولیک; Trichloroethylene; Metabolism; Interactions; Inhibition; Rat liver microsomes; Rat hepatocytes; Metabolic clearance; Trichloroethanol; Trichloroacetate; Drugs; Pharmaceuticals;
In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis
Keywords: ترخیص متابولیک; daphnetin; glucuronidation; methyl substitution; structural modification; metabolic stability; phase II enzymes; glucuronosyl-transferases; human liver microsomes; enzyme kinetics; metabolic clearance;
Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies
Keywords: ترخیص متابولیک; distribution; hepatocytes; liver; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Disposition of ON 01210.Na (Ex-RAD(R)), a Novel Radioprotectant, in the Isolated Perfused Rat Liver: Probing Metabolic Inhibition to Increase Systemic Exposure
Keywords: ترخیص متابولیک; metabolic clearance; disposition; drug interactions; hepatic metabolism; glutathione-S-transferases; preclinical pharmacokinetics;
Development of a Hybrid Physiologically Based Pharmacokinetic Model with DrugâSpecific Scaling Factors in Rat to Improve Prediction of Human Pharmacokinetics
Keywords: ترخیص متابولیک; ADME; in vitroâin vivo extrapolation (IVIVE); metabolic clearance; modeling and simulation; PBPK modeling; pharmacokinetics; physiological model; prediction of human pharmacokinetics; simulations; translational research;
Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs
Keywords: ترخیص متابولیک; In vitro/in vivo; Hepatocytes; Metabolic clearance; Permeability; Diffusion
Effect of Intestinal First-Pass Hydrolysis on the Oral Bioavailability of an Ester Prodrug of Fexofenadine
Keywords: ترخیص متابولیک; absorption; intestinal absorption; bioavailability; intestinal metabolism; pharmacokinetics; prodrugs; oral drug delivery; metabolic clearance; first-pass metabolism; intestinal secretion/transport
In Vitro-In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods
Keywords: ترخیص متابولیک; disposition; microsomes; hepatic clearance; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes
Keywords: ترخیص متابولیک; hepatic clearance; hepatic metabolism; hepatocytes; metabolic clearance; CYP enzymes; cytochrome P450; clearance; flavin monooxygenases (FMO);
Interspecies Scaling in Pharmacokinetics: A Novel Whole-Body Physiologically Based Modeling Framework to Discover Drug Biodistribution Mechanisms in vivo
Keywords: ترخیص متابولیک; nonlinear pharmacokinetics; whole-body physiologically based pharmacokinetic model; cyclosporin; scaling; biodistribution; animal model; metabolic clearance; drug transport; preclinical pharmacokinetics; individualized drug therapy;
Update on the Pharmacokinetics and Redox Properties of Protein-Bound Uremic Toxins
Keywords: ترخیص متابولیک; albumin; antioxidants; metabolic clearance; free radicals; protein binding; membrane transport; organic anion transporters; pharmacokinetics; protein binding; renal transport
Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes
Keywords: ترخیص متابولیک; distribution; microsomes; clearance; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Interstrain Differences of In Vitro Metabolic Stability and Impact on Early Drug Discovery
Keywords: ترخیص متابولیک; ADME; high-performance/pressure liquid chromatography (HPLC); microsomes; mass spectrometry; in vitro models; metabolic clearance; cytochrome P450; phase I metabolism;
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes
Keywords: ترخیص متابولیک; hepatic metabolism; enzyme kinetics; phase II enzymes; glucuronosyltransferases (UGT); metabolic clearance;
Extrapolating In vitro Metabolic Interactions to Isolated Perfused Liver: Predictions of Metabolic Interactions between R-Bufuralol, Bunitrolol, and Debrisoquine
Keywords: ترخیص متابولیک; metabolism in vitro; in vitro-in vivo extrapolation; IVIVE; drug interaction; DDI; microsomes; liver model; isolated perfused liver; metabolic clearance; PBPK modeling;
Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats
Keywords: ترخیص متابولیک; BBR; pharmacokinetics; metabolic clearance; microsomes; enzyme kinetics; CYPs; UGTs;
Assessment of Presystemic and Systemic Intestinal Availability of Orally Administered Drugs Using In Vitro and In Vivo Data in Humans: Intestinal Sulfation Metabolism Impacts Presystemic Availability Much More Than Systemic Availability of Salbutamol, SUL
Keywords: ترخیص متابولیک; intestinal metabolism; metabolic clearance; bioavailability; firstâpass metabolism; phase II metabolism;
Prediction of Plasma Protein Binding Displacement and its Implications for Quantitative Assessment of Metabolic Drug-Drug Interactions from In Vitro Data
Keywords: ترخیص متابولیک; protein binding; displacement; drug interaction; metabolic clearance; prediction; metabolically based drug-drug interactions; pharmacokinetics; simulations;
Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition
Keywords: ترخیص متابولیک; oltipraz; protein-calorie malnutrition; cysteine; CYP enzymes; metabolic clearance; pharmacokinetics; rats;