Modulation of trichloroethylene in vitro metabolism by different drugs in rats

► Nine out 14 tested drugs interfere with TCE metabolism in rat hepatocytes. ► Naproxen causes partial competitive inhibition of TCOH glucuronidation.. ► Gliclazide and vaproate cause partial non competitive inhibition of TCE oxidation.. ► Some inhibition constant values are within range of plasma levels during treatment.