Keywords: hepatocytes موش; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
مقالات ISI hepatocytes موش (ترجمه نشده)
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Keywords: hepatocytes موش; DILI; drug-induced liver injury; Mrp2; multidrug resistant protein 2; HCI; high content imaging; High content imaging; Rat hepatocytes; Hepatotoxicity; In vitro model; Long-term culture; Safety profiling;
Keywords: hepatocytes موش; Trichloroethylene; Metabolism; Interactions; Inhibition; Rat liver microsomes; Rat hepatocytes; Metabolic clearance; Trichloroethanol; Trichloroacetate; Drugs; Pharmaceuticals;
Metabolism of the synthetic cannabinoid 5F-PY-PICA by human and rat hepatocytes and identification of biliary analytical targets by directional efflux in sandwich-cultured rat hepatocytes using UHPLC-HR-MS/MS
Keywords: hepatocytes موش; AAUC; Area under the curve; CB; Cannabinoid receptors; CDFDA; 5-(6)-carboxy-2â²,7â²-dichlorofluorescein diacetate; DMEM; Dulbecco's modified Eagle's medium; EGTA; Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid; FBS; Fetal bovi
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: hepatocytes موش; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling
Keywords: hepatocytes موش; Protein malnutrition; Fatty liver; Insulin; Triglycerides synthesis; Rat hepatocytes;
Biotransformation of the fungal neurotoxin Thomitrem A by primary rat hepatocytes
Keywords: hepatocytes موش; Biotransformation; Rat hepatocytes; Metabolites; Prediction; Thomitrem A; Toxicokinetics;
Nodularin-triggered apoptosis and hyperphosphorylation of signaling proteins in cultured rat hepatocytes
Keywords: hepatocytes موش; Apoptosis; Nodularin; Phosphorylation; Rat hepatocytes; Signalling proteins;
Hepatoprotection of sesquiterpenoids: A quantitative structure-activity relationship (QSAR) approach
Keywords: hepatocytes موش; Hepatoprotection; Lipid peroxidation; Quantitative structure-activity relationship; Rat hepatocytes; Sesquiterpenoids; TBARS;
Evaluation of a Liver Microfluidic Biochip to Predict In Vivo Clearances of Seven Drugs in Rats
Keywords: hepatocytes موش; hepatic clearance; in vitro model; mathematical model; pharmacokinetics; microfluidic biochips; drug metabolism; rat hepatocytes;
Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)
Keywords: hepatocytes موش; Rat hepatocytes; Mitochondrial biogenesis; Mitochondrial respiration; PPAR; mTOR; Hypertrophy;
N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes
Keywords: hepatocytes موش; N-acetylcysteine; Fluoride; Fluorosis; Oxidative stress; Rat hepatocytes
19F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells
Keywords: hepatocytes موش; 19F-heptuloses; GLUT2-expressing cells; Rat hepatocytes; Insulin secretion; Rat pancreatic islets
A new approach on valproic acid induced hepatotoxicity: Involvement of lysosomal membrane leakiness and cellular proteolysis
Keywords: hepatocytes موش; Valproic acid; Cellular proteolysis; Lysosomes; Oxidative stress; Mitochondrial/lysosomal cross-talk; Rat hepatocytes;
Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia
Keywords: hepatocytes موش; Hyperglycemia; Tinospora cordifolia; RINm5F pancreatic β-cell line; Rat hepatocytes;
Primary rat hepatocytes in chemical testing and QSAR predictive applicability
Keywords: hepatocytes موش; Rat hepatocytes; Cell viability; Ureogenesis; QSAR; Aliphatic alcohols; Esters
Effect of cell spot sizes on micropatterned cultures of rat hepatocytes
Keywords: hepatocytes موش; Rat hepatocytes; Micropatterning culture; Collagen; Polyethylene glycol; Liver-specific function; mRNA expression
The toxic effect of thioacetamide on rat liver in vitro
Keywords: hepatocytes موش; TAA, thioacetamide; TMRM, tetramethylrhodamine methyl ester; CM-H2DCFDA, 5- and 6-chloromethyl-2’7’-dichlorodihydrofluorescein diacetate; MMP, mitochondrial membrane potentialThioacetamide; Rat hepatocytes; Oxidative stress; Mitochondria; ROS
Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes
Keywords: hepatocytes موش; DCHF-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DCNP; 2,6-dichloro-4-nitrophenol; DMSO; dimethyl sulfoxide; GSH; glutathione; GSSG; glutathione disulfide; HEPES; N-(2-hydroxyethyl)-piperazine-N-(2-ethanesulfonic acid); MDA; malondialdehyde; MPT;
Doxorubicin induces ceramide and diacylglycerol accumulation in rat hepatocytes through independent routes
Keywords: hepatocytes موش; Doxorubicin; Ceramide; Sphingomyelin metabolism; Diacylglycerol acyltransferase; Rat hepatocytes
Microchip electrophoresis with chemiluminescence detection for assaying ascorbic acid and amino acids in single cells
Keywords: hepatocytes موش; Microchip electrophoresis; Chemiluminescence detection; Single cell analysis; Ascorbic acid; Tryptophan; Rat hepatocytes
Primary throughput screening of protectants for hypothermic preservation of bioartificial liver in gel entrapped hepatocytes
Keywords: hepatocytes موش; Hypothermic preservation; Rat hepatocytes; Bioartificial liver (BAL); Gel entrapment culture; Chinese herbal medicine; Glycyrrhizic acid (GA)
Morphological and functional studies of rat hepatocytes on a hydrophobic or hydrophilic polydimethylsiloxane surface
Keywords: hepatocytes موش; Rat hepatocytes; PDMS; Hydrophobic; Hydrophilic; FBS
Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by 31P NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholines
Keywords: hepatocytes موش; 31P NMR spectroscopy; MALDI-TOF MS; Carbon tetrachloride; Rat hepatocytes; Oxidative stress; Phosphatidylcholine; Lysophosphatidylcholine
Gel entrapment culture of rat hepatocytes for investigation of tetracycline-induced toxicity
Keywords: hepatocytes موش; ATP; adenosine triphosphate; Crat; carnitine acyltransferase; CYP; cytochrome; Dci; dodecenoyl-CoA delta isomerase; DTNB; 5,5-dithiobis(2-nitrobenzoic acid); GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GSH; glutathione; MDA; malondialdehyde; MTT; met
Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes
Keywords: hepatocytes موش; Enzyme induction; mRNA expression; Rat hepatocytes; Human hepatocytes
Potential hepatoprotective effects of new Cuban natural products in rat hepatocytes culture
Keywords: hepatocytes موش; Natural products; Lipid peroxidation; GSH; Rat hepatocytes; Antioxidants; Hepatoprotection
Modulation of P450 enzymes by Cuban natural products rich in polyphenolic compounds in rat hepatocytes
Keywords: hepatocytes موش; Cuban herbal products; Rat hepatocytes; Cytochrome P450; Polyphenols
High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes
Keywords: hepatocytes موش; Antiretroviral drugs; Stavudine; Toxicity; Liver; Rat hepatocytes; Mitochondria; Fatty acid oxidation; Mitochondrial DNA; Steatosis; Steatohepatitis
Modulation of CYP1A1 and CYP2B1 expression upon cell cycle progression in cultures of primary rat hepatocytes
Keywords: hepatocytes موش; C/EBP; CCAAT/enhancer binding protein; CDK1; cyclin-dependent kinase 1; CYP; cytochrome P450; BSA; bovine serum albumin; DSM; differentiation stimulating medium; EGF; epidermal growth factor; EROD; 7-ethoxyresorufin-O-deethylase; FBS; fetal bovine serum;
An in vitro model for long-term hepatotoxicity testing utilizing rat hepatocytes entrapped in micro-hollow fiber reactor
Keywords: hepatocytes موش; Micro-hollow fiber reactor; Hepatocyte monolayer; Rat hepatocytes
Lithium ions increase hepatic glycogen synthase stability through a proteasome-related mechanism
Keywords: hepatocytes موش; Rat hepatocytes; Lithium ions; Glycogen synthase; Protein stability
Determination of reduced and oxidized glutathione in biological samples using liquid chromatography with fluorimetric detection
Keywords: hepatocytes موش; Reduced and oxidized glutathione; Whole blood; Rat hepatocytes; Orthophthalaldehyde; N-Ethylmaleimide
Effects of Mangifera indica L. aqueous extract (Vimang) on primary culture of rat hepatocytes
Keywords: hepatocytes موش; Mangifera indica L; Rat hepatocytes; Cytotoxicity; Cytochrome P450; Lipid peroxidation; GSH
Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes
Keywords: hepatocytes موش; TSA; Rat hepatocytes; Albumin; Cytochrome P450; Differentiation; LETF
Comparative cytotoxicity of alkyl gallates on mouse tumor cell lines and isolated rat hepatocytes
Keywords: hepatocytes موش; Alkyl gallates; Tumor cell respiration; Oxygen consumption; Electron flow; Cytotoxicity; Cell culture growth; Solid tumor growth; Rat hepatocytes; Resistance
Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes
Keywords: hepatocytes موش; Apoptosis; Cytochrome P450 2E1; Reactive oxygen species; Reduced glutathione; S-Adenosyl-l-methionine; Chlormethiazole; Pyrazole; Cycloleucine; Rat hepatocytes
Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid
Keywords: hepatocytes موش; Trichloroethylene; Chloral hydrate; Trichloroethanol; Trichloroacetic acid; Formic acid; Human renal proximal tubule cells; Rat hepatocytes
Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: Implications for fingerprint profiling of cytotoxicity
Keywords: hepatocytes موش; Cytotoxicity; Stress proteins; Metallothionein; Heat shock proteins; Cadmium; Arsenic; Phenotypic anchoring; FGC4 cells; Rat hepatocytes; HepG2 cells
Cadmium-induced apoptosis in rat hepatocytes does not necessarily involve caspase-dependent pathways
Keywords: hepatocytes موش; Cadmium; Rat hepatocytes; Apoptosis; Caspases; Cytochrome c; AIFAIF, apoptosis-inducing factor; DEVD-AMC, Ac-Asp-glu-Val-Asp-(7-amino-4-methylcoumarin); Ac-LEHD-AFC, Ac-Leu-Glu-His-Asp-(7-amino-4-trifluoromethylcoumarin); Z-IETD-AFC, Z-Ile-Glu-Thr-Asp-(7-
Hepatocyte production of modulators of extracellular liver matrix in normal and cirrhotic rat liver
Keywords: hepatocytes موش; Rat hepatocytes; Matrix metalloproteinases; Tissue Inhibitors of matrix metalloproteinases; Extracellular matrix; CCl4-induced liver cirrhosis; Cirrhosis; Normal liver
The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats
Keywords: hepatocytes موش; Salvia officinalis L. infusion; Glutathione status; Antioxidant effects; Rat hepatocytes; Mice; tert-Butyl hydroperoxide;
DNA strand breaking capacity of acrylamide and glycidamide in mammalian cells
Keywords: hepatocytes موش; V79; Caco-2; Rat hepatocytes; Strand breaks; Comet assay; Glutathione; Cytotoxicity;
Differential effect of interleukin-10 on hepatocyte apoptosis
Keywords: hepatocytes موش; Apoptosis; IL-10; NF-κB; Rat hepatocytes; HepG2