Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)

► We investigated mechanisms of mitochondrial regulation in rat hepatocytes. ► Tetradecylthioacetic acid (TTA) was employed to activate mitochondrial oxidation. ► Mitochondrial biogenesis and respiration were induced. ► It was confirmed that PPAR target genes were induced. ► The mechanism involved activation mTOR.