Keywords: میکروسوم های کبدی موش; AIDS; acquired immunodeficiency syndrome; AUC; area under the plasma concentration versus time curve of NVP in absence of NT; AUCI; area under the plasma concentration versus time curve of NVP in presence of NT; AUCratio; ratio between AUCI and AUC (AUCI/
مقالات ISI میکروسوم های کبدی موش (ترجمه نشده)
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Keywords: میکروسوم های کبدی موش; AD; Alzheimer's disease; Aβ; amyloid β peptide; APP; amyloid precursor protein; BACE1; β-amyloid cleavage enzyme 1, β-secretase 1; GSM; gamma secretase modulator; LHS; left hand side; NSAID; non-steroidal anti-inflammatory drug; SAR; structure activ
Keywords: میکروسوم های کبدی موش; CLint; Intrinsic hepatic clearance; HLM; Human liver microsomes; LC/MS/MS; Liquid chromatography tandem mass spectrometry; LC/UV/RAD; Liquid chromatography/ultraviolet/radioactive detection; MRM; Multiple reaction monitoring; NADPH; Nicotinamide adenine d
Keywords: میکروسوم های کبدی موش; UPLC; ultra-performance liquid chromatography; A; aloe-emodin; R; rhein; E; emodin; CP; chrysophanol; PS; physcion; AG; aloe-emodin-8-O-β-D-glucopyranoside; EG; emodin-8-O-β-D-glucopyranoside; RG; rhein-8-O-glucopyranoside; DMSO; dimethyl sulfoxide; CE;
Keywords: میکروسوم های کبدی موش; Phthalate; Hydrolytic metabolism; Carboxylesterase; Rat liver microsomes; Rat small-intestinal microsomes; Substrate specificity;
Keywords: میکروسوم های کبدی موش; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
Keywords: میکروسوم های کبدی موش; PM; plasmepsin; SPP; signal peptide peptidase; HIV; human immunodeficiency virus; SAR; structure-activity relationships; BACE; beta-site APP cleaving enzyme 1 or beta-secretase; TCAMS; Tres Cantos Antimalarial Set; RBC; red blood cells; CatD; cathepsin
Keywords: میکروسوم های کبدی موش; AcAlaPNA; N-Acetyl-l-alanyl-p-nitroanilide; AChE; acetylcholinesterase; APH; acylpeptide hydrolase; αNB; alpha-naphthyl butyrate; BChE; butyrylcholinesterase; BTC; S-butyrylthiocholine iodide; CBDP; [2-(o-cresyl)-4H-1,3,2-benzodioxaphosphoran-2-one]; CES
Keywords: میکروسوم های کبدی موش; Trichloroethylene; Metabolism; Interactions; Inhibition; Rat liver microsomes; Rat hepatocytes; Metabolic clearance; Trichloroethanol; Trichloroacetate; Drugs; Pharmaceuticals;
Keywords: میکروسوم های کبدی موش; cocktail; cytochrome P450; inhibition; rat liver microsomes; Reduning Injection
Investigation of metabolic stability of the novel ALK inhibitor brigatinib by liquid chromatography tandem mass spectrometry
Keywords: میکروسوم های کبدی موش; Brigatinib; Quantification; Rat liver microsomes; LC-MS/MS; Human plasma; Metabolic stability estimation;
Investigation of metabolic degradation of new ALK inhibitor: Entrectinib by LC-MS/MS
Keywords: میکروسوم های کبدی موش; Entrectinib; Quantification; LC-MS/MS; Human plasma; Metabolic degradation assessment; Rat liver microsomes;
Food-drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat
Keywords: میکروسوم های کبدی موش; APC; 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxy-camptothecin; AUC; Area under the plasma concentration-time curve; CAP; Capsaicin; CES; Carboxylesterase; CPT; Camptothecin; CPT-11; Irinotecan; CYP; cytochrome P450; DMEs; Drug-meta
Sulfotransferase-catalyzed biotransformation of liguzinediol and comparison of its metabolism in different species using UFLC-QTOF-MS
Keywords: میکروسوم های کبدی موش; LZDO; liguzinediol; Cys; cysteine; NAC; N-acetylcysteine; GSH; glutathione; 2-NAC-LZDO; 2-N-acetylcysteine-LZDO; 2-Cys-LZDO; 2-cysteine-LZDO; 2-GSH-LZDO; 2-glutathione-LZDO; HLC; human liver cytosol; HLM; human liver microsomes; RLC; rat liver cytosol; RL
Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of sinomenine in rats through cytochrome P450-mediated pathways
Keywords: میکروسوم های کبدی موش; RA; rheumatoid arthritis; CV; cardiovascular; CYP enzyme; cytochrome P450 enzyme; DDI; drug-drug interaction; RLMs; rat liver microsomes; IS; internal standard; Sinomenine (PubChem CID: 5459308); Simvastatin (PubChem CID: 54454); Lovastatin (PubChem CID:
Untargeted screening of phase I metabolism of combretastatin A4 by multi-tool analysis
Keywords: میکروسوم های کبدی موش; Rat liver microsomes; Electrochemistry; LC-HRMS; Solid phase microextraction; In silico; Drug metabolism; Combretastatin A4;
Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats
Keywords: میکروسوم های کبدی موش; AD; alzheimer's disease; AUCINF; area under the concentration time curve from time zero to the last sampling time plus the extrapolated area (i.e., the last concentration divided by the elimination rate constant); AUClast; area under the concentration t
Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes
Keywords: میکروسوم های کبدی موش; Estradiol (PubChem CID: 5757); Chenodeoxycholic acid (PubChem CID: 10133); Serotonin (PubChem CID: 5202); Propofol (PubChem CID: 4943); Zidovudine (PubChem CID: 35370); CYP; cytochrome P450; UGT; UDP-glucuronosyltransferases; DDI; drug-drug interactions;
In vitro effect of mPEG2k-PCLx micelles on rat liver cytochrome P450 enzymes
Keywords: میکروسوم های کبدی موش; Ahr; aryl hydrocarbon receptor; Car; constitutive androstane receptor; Pxr; pregnane X receptor; mPEG2k-PCLx micelles; Cytochrome P450 enzymes; Inhibition; Induction; Rat liver microsomes; Primary rat hepatocytes;
Metabolism profiling of nevadensin in vitro and in vivo by UHPLC-Q-TOF-MS/MS
Keywords: میکروسوم های کبدی موش; Nevadensin; UHPLC-Q-TOF-MS/MS; In vitro and in vivo; Metabolism; KFI; Rat liver microsomes;
Comprehensive characterization of in vitro and in vivo metabolites of 2â²,3â²,5â²âtriâOâacetylâN6â(3âhydroxyphenyl) adenosine and study of the metabolites distribution in rats by combined methods of HPLC-DAD, off-line cryoNMR, and HPLC-QTOF
Keywords: میکروسوم های کبدی موش; RLMs; rat liver microsomes; HPLC-DAD; high-performance liquid chromatography coupled to a diode array detector; cryoNMR; cryogenically cooled probe nuclear magnetic resonance; UPLC-QTOFMS; ultra-performance LC-quadrupole TOF MS; AMPK; AMP-activated protei
Bioactivation of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene, by rat liver microsomes
Keywords: میکروسوم های کبدی موش; Metabolism; Rat liver microsomes; 1-chloro-2-hydroxy-3-butene; 1-chloro-3,4-epoxy-2-butanol; 1-chloro-3-buten-2-one; 1,3-butadiene; ADH; alcohol dehydrogenase; BD; 1,3-butadiene; BDD; 3-buten-1,2-diol; BI; 1-benzylimidazole; CBO; 1-chloro-3-buten-2-one; C
A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine
Keywords: میکروسوم های کبدی موش; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: میکروسوم های کبدی موش; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
A validated LC-MS/MS method for the estimation of glimepiride and pitavastatin in rat plasma: Application to drug interaction studies
Keywords: میکروسوم های کبدی موش; Glimepiride; Pitavastatin; LC-MS/MS; Drug interaction; Rat liver microsomes;
In silico and in vitro inhibition of cytochrome P450 3A by synthetic stilbenoids
Keywords: میکروسوم های کبدی موش; CYP; cytochrome P450; P450s; cytochrome P450 enzymes; RLM; rat liver microsomes; CYP3A4; Resveratrol; Nitrostilbene; Di-methoxy-nitrostilbene; Microsomes; Docking;
Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception
Keywords: میکروسوم های کبدی موش; Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;
Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine
Keywords: میکروسوم های کبدی موش; Experimental colitis; Dextran sulfate sodium; CYPs; Rat liver microsomes; Rat renal microsomes; Rat intestinal microsomes;
Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups
Keywords: میکروسوم های کبدی موش; S1P1 receptor agonist; Immunomodulator; Lymphocyte count; Aminomethyl pyridine; Aminomethyl benzene; Aminomethyl thiophene; Phototoxicity; BuLi; n-butyl lithium; CC; column chromatography; DCM; dichloromethane; DIPEA; diisopropylethylamine; DEAD; diethyl
In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes
Keywords: میکروسوم های کبدی موش; l-Corydalmine; Metabolism; Hepatic microsomes; Cytochrome P450s; Interspecies difference; CyLM; cynomolgus monkey liver microsomes; CYP450; cytochrome P450; DLM; dog liver microsomes; HLM; human liver microsomes; HPLC; high-performance liquid chromatograp
Mechanism-based inactivation of cytochrome P450 2B6 by isoimperatorin
Keywords: میکروسوم های کبدی موش; CE; collision energy; DMSO; dimethyl sulfoxide; EPI; enhanced product ion; GSH; glutathione; IDA; information-dependent acquisition; IIMP; isoimperatorin; LC; liquid chromatography; LC-MS/MS; liquid chromatography coupled to tandem mass spectrometry; MR
6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-14C] 6:2 fluorotelomer alcohol
Keywords: میکروسوم های کبدی موش; 6:2 Fluorotelomer iodide (6:2 FTI); 6:2 Fluorotelomer alcohol (6:2 FTOH); 5:3 Acid; Perfluorocarboxylic acids (PFCAs); In vitro metabolism; Rat liver microsomes;
Biotransformation of isoimperatorin by rat liver microsomes and its quantification by LC-MS/MS method
Keywords: میکروسوم های کبدی موش; Isoimperatorin; Metabolism; Rat liver microsomes; LC-QqQ-MS; Qualitative analysis; Quantitative analysis;
In vitro metabolism of cis- and trans-permethrin by rat liver microsomes, and its effect on estrogenic and anti-androgenic activities
Keywords: میکروسوم های کبدی موش; trans-Permethrin; cis-Permethrin; 3-Phenoxybenzyl alcohol; Rat liver microsomes; Estrogenic activity; Anti-androgenic activity;
Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride
Keywords: میکروسوم های کبدی موش; Dipfluzine hydrochloride; Metabolism; Rat liver microsomes; CYP450 enzymes
Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes
Keywords: میکروسوم های کبدی موش; TP; triptolide; TWHF; Tripterygium wilfordii Hook. F.; CYP; cytochrome P450; RLM; rat liver microsomes; SCRH; sandwich-cultured rat hepatocytes; LDH; lactate dehydrogenase; AST; aspartate transaminase; ALT; alanine aminotransferase; MDA; malondialdehyde;
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins
Keywords: میکروسوم های کبدی موش; AαBA; 3-acetyl-α-boswellic acid; AβBA; 3-acetyl-β-boswellic acid; AKBA; 3-acetyl-11-keto-β-boswellic acid; BA; boswellic acid; αBA; α-boswellic acid; βBA; β-boswellic acid; BSE; Boswellia serrata gum resin extract; HLM; human liver microsomes; KB
Concentration-dependent inhibitory effects of baicalin on the metabolism of dextromethorphan, a dual probe of CYP2D and CYP3A, in rats
Keywords: میکروسوم های کبدی موش; S. baicalensis; Scutellaria baicalensis; CYP; cytochrome P450; CYP2D; cytochrome P450 2D; CYP3A; cytochrome P450 3A; DXM; dextromethorphan; BG; baicalin; RLMs; rat liver microsomes; Km; substrate concentration at half-maximal product formation rate; Ki; i
Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases
Keywords: میکروسوم های کبدی موش; CD; Choline-deficient; CYP; Cytochrome P450; ESI; Electrospray ionization; FDA; Food and Drug Administration; IACUC; Institutional Animal Care and Use Committee; IS; Internal standard; HPLC; High-performance liquid chromatography; LC-MS/MS; Liquid chromat
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites
Keywords: میکروسوم های کبدی موش; DTNB; 5,5â²-dithiobis(2-nitrobenzoic acid); GSH; reduced glutathione; GTP; guanosine-5â²-triphosphate; HLM; human liver microsomes; NAC; N-acetyl-L-cysteine; NEM; N-ethyl-maleimide; MEM; minimal essential medium; MTT; (3-(4,5-dimethylthiazol-2-yl)-2,5-d
In vitro metabolism of alisol A and its metabolites' identification using high-performance liquid chromatography-mass spectrometry
Keywords: میکروسوم های کبدی موش; Alisol A; Metabolism; HPLC-QTOF MS; Rat liver microsomes; Human liver microsomes;
In vitro metabolism study of the promising anticancer agent the lignan (−)-grandisin
Keywords: میکروسوم های کبدی موش; Grandisin; In vitro metabolism; Method validation; CYP450; Rat liver microsomes; Dihydro-grandisin metabolite
Optimized proteomic analysis of rat liver microsomes using dual enzyme digestion with 2D-LC–MS/MS
Keywords: میکروسوم های کبدی موش; Membrane proteins; Rat liver microsomes; Dual enzyme digestion; Quadrupole-time-of-flight (QqTOF); Solubilizing agents; Strong cation exchange
Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
Keywords: میکروسوم های کبدی موش; DTT; dithiothreitol; HLM; human liver microsomes; HRN; Hepatic Reductase Null mouse; POR; NADPH-P450 oxidoreductase; RLM; rat liver microsomes; WT; wild type; Antitumour agents; Capridine β; C-1748; Hypoxia; Metabolism; 1-Nitroacridines;
Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism
Keywords: میکروسوم های کبدی موش; Antioxidant; Cytochrome P450; Fe3+/ascorbate; Melatonin; Rat liver microsomes; Reactive oxygen species
Assay of labile estrogen o-quinones, potent carcinogenic molecular species, by high performance liquid chromatography–electrospray ionization tandem mass spectrometry with phenazine derivatization
Keywords: میکروسوم های کبدی موش; Liquid chromatography–electrospray ionization tandem mass spectrometry; o-Quinone; Immobilized iodoxybenzoic acid; Phenazine derivative; Tyrosinase; Rat liver microsomes
The mechanism of the rat liver cytochrome P4502E1 inhibition by the synthetic prostanoids of A-type
Keywords: میکروسوم های کبدی موش; Prostaglandin A2 analogs; Cytochrome P4502E1; Cytoprotection; Rat liver microsomes;
Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1â²-hydroxylation and 4-hydroxylation of midazolam
Keywords: میکروسوم های کبدی موش; SMI; Shenmai injection; MDZ; midazolam; 1â²-OH MDZ; 1â²-hydroxymidazolam; 4-OH MDZ; 4-hydroxymidazolam; TG; total ginsenoside; OTS; ophiopogon total saponins; OTF; ophiopogon total flavone; KTZ; ketoconazole; RLM; rat liver microsomes; HLM; human liver
Fatty acid profiles in hepatic membranes of rats with different levels of circulating estrogen and prolactin
Keywords: میکروسوم های کبدی موش; Prolactin; 17β-estradiol; Bromocriptine; Polyunsaturated fatty acids; Rat liver microsomes; Unsaturation index;
Normal-phase HPLC and HPLC-MS studies of the metabolism of a cytosolic phospholipase A2α inhibitor with activated ketone group by rat liver microsomes
Keywords: میکروسوم های کبدی موش; Metabolism; Rat liver microsomes; Activated ketone; Hydrate; Normal-phase chromatography; Cyano-phase;