
Keywords: SSc; systemic sclerosis; SRC; scleroderma renal crisis; PAH; pulmonary arterial hypertension; SMR; standardized mortality ratio; DNMTs; DNA methyltransferases; SAM; S-adenosyl-methionine; 5mC; 5-methylcytosine; MBD; methyl-CpG-binding domain; Tet; ten-e