
Downregulation of HIF-1a sensitizes U251 glioma cells to the temozolomide (TMZ) treatment
Keywords: TMZ, temozolomide; HIF-1α, hypoxia inducible factor 1α; MTT, 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; MGMT, O6-methylguanine DNA methyltransferase; PFS, progression-free-survival; GBM, glioblastoma multiforme; HREs, hypoxia response