Keywords: MHC، زنجیره سنگین میوزین; ATMP, advanced therapy medicinal product; CM, cardiomyocyte; cTNT, cardiac Troponin T; CVP, cardiovascular progenitor; EB, embryoid body; GMP, good manufacturing practice; hPSC, human pluripotent stem cell; MHC, myosin heavy chain; RI, ROCK inhibitor; SA,
مقالات ISI MHC، زنجیره سنگین میوزین (ترجمه نشده)
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Keywords: MHC، زنجیره سنگین میوزین; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Skeletal muscle; Ragged-red fibers; MitochondriaMS, multiple sclerosis; ETC, electron transport chain; MHC, myosin heavy chain; EAE, experimental autoimmune encephalomyelitis; MOG, myelin olig
Keywords: MHC، زنجیره سنگین میوزین; ESCs, embryonic stem cells; EBs, embryoid bodies; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; MHC, myosin heavy chain; MLC, myosin light chain; ANP, atrium natriuretic peptideStatin; Myogenesis; Transcription; Cholesterol synthesis; S
Keywords: MHC، زنجیره سنگین میوزین; cTnT, cardiac troponin-T; CM, cardiomyocyte; EB, embryoid body; hESC, human embryonic stem cells; hiPSC, HUMAN induced pluripotent stem cells; MC, microcarrier; MHC, MYOSIN heavy chain
Effect of acute and chronic eccentric exercise on FOXO1 mRNA expression as fiber type transition factor in rat skeletal muscles
Keywords: MHC، زنجیره سنگین میوزین; FoxO, Forkhead box O; MHC, Myosin heavy chain; SVL, Super vastus lateralis; GAPDH, Glyceraldehyde-3-phosphate dehydrogenase; TOS, Total oxidative status; MDA, MalondialdehydeEccentric exercise; Fiber-type transition; Skeletal muscle; Gene expression
Ethanol extract of Cyclolepis genistoides D. Don (palo azul) induces formation of myotubes, which involves differentiation of C2C12 myoblast cells
Keywords: MHC، زنجیره سنگین میوزین; Differentiation; Palo azul; Myoblasts; Myogenin; Myosin heavy chain; MyotubeDMSO, dimethyl sulfoxide; FBS, fetal bovine serum; IGF-1, insulin-like growth factor-1; MHC, myosin heavy chain; OA, oleanolic acid; Palo, ethanol extract of palo azul; PPARγ, per
The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy
Keywords: MHC، زنجیره سنگین میوزین; calcium; cardiomyopathy; L-type calcium channel; mitochondria[Ca2+]i, intracellular calcium; HCM, hypertrophic cardiomyopathy; ICa-L, L-type Ca2+ channel; MHC, myosin heavy chain; VDAC, voltage-dependent anion channel; Ψm, mitochondrial membrane potential
A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila
Keywords: MHC، زنجیره سنگین میوزین; RCM, restrictive cardiomyopathy; HCM, hypertrophic cardiomyopathy; IFM, indirect flight muscles; MHC, myosin heavy chain; RT-PCR, reverse transcription-polymerase chain reaction; RLC, regulatory light chainmyofibril; motility; electron microscopy; contrac
Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease
Keywords: MHC، زنجیره سنگین میوزین; ATP, adenosine triphosphate; Ca2 +, calcium; CTER, calmodulin, troponin C, essential and regulatory light chains of myosin; E, embryonic day; FHC, familial hypertrophic cardiomyopathy; MHC, myosin heavy chain; MLC-1, myosin light chain-1; MYL2/MLC-2, myos
A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells
Keywords: MHC، زنجیره سنگین میوزین; GFP, green fluorescence protein; GPA, β-guanidinopropionic acid; IGF1, insulin-like growth factor-1; LLC, Lewis lung carcinoma; MAFbx, Muscle Atrophy F-Box; MHC, myosin heavy chain; MuRF1, Muscle RING-finger-1; TAZ, transcriptional coactivator with PDZ bi
Ectopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation
Keywords: MHC، زنجیره سنگین میوزین; msx2, msh (muscle segment homeodomain) homeobox homolog 2; msx1, msh homeobox homolog 1; MHC, myosin heavy chain; Mrf4, muscle regulatory factor 4; Ptgs2, prostaglandin-endoperoxide synthase 2; Ptger4, prostaglandin E receptor 4; TSA, trichostatin A; BMP4
Collagen represses canonical Notch signaling and binds to Notch ectodomain
Keywords: MHC، زنجیره سنگین میوزین; EGF, epidermal growth factor; DDR, discoidin domain receptor; HES, hairy enhancer of split; SMA, smooth muscle actin; MHC, myosin heavy chain; DAPT, N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester; RNA, ribonucleic acidCollagen; Notc
Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity
Keywords: MHC، زنجیره سنگین میوزین; DM, differentiation medium; GM, growth medium; MHC, myosin heavy chain; MRFs, myogenic regulatory factorsNek5; Muscle differentiation; Caspase-3; C2C12 myoblast
Distinct effects of methamphetamine on autophagy–lysosome and ubiquitin–proteasome systems in HL-1 cultured mouse atrial cardiomyocytes
Keywords: MHC، زنجیره سنگین میوزین; MAP, methamphetamine; GFP, green fluorescent protein; LC3, microtubules-associated protein light chain3; LAMP1, lysosome-associated membrane protein1; Nrf2, nuclear factor erythroid-2 related factor; HO-1, heme oxygenase-1; MHC, myosin heavy chain; MuRF1,
Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation
Keywords: MHC، زنجیره سنگین میوزین; EPO, erythropoietin; EpoR, erythropoietin receptor; PGC-1α, Peroxisome proliferator-activated receptor gamma coactivator-1 alpha; AMPK, AMP-activated protein kinase; SDH, succinic dehydrogenase; MHC, myosin heavy chain; WT, wild type; IDH3α, dehydrogenase
miR-128 regulates non-myocyte hyperplasia, deposition of extracellular matrix and Islet1 expression during newt cardiac regeneration
Keywords: MHC، زنجیره سنگین میوزین; BrdU, bromodeoxyuridine; dpi, days post injury; LNA, Locked Nucleic Acid; MHC, myosin heavy chain; miRNA, microRNA; UTR, untranslated regionHeart; Hyperplasia; Islet1; miR-128; Newt; Regeneration
Right Heart Adaptation to Pulmonary Arterial Hypertension : Physiology and Pathobiology
Keywords: MHC، زنجیره سنگین میوزین; echocardiography; heart failure; MRI; myocardium; pulmonary artery hypertension; right ventricleBNP, B type natriuretic peptide; CO, cardiac output; Ea, arterial elastance; Ees, ventricular elastance; LV, left ventricular; MHC, myosin heavy chain; MPAP, m
Severe atrophy of slow myofibers in aging muscle is concealed by myosin heavy chain co-expression
Keywords: MHC، زنجیره سنگین میوزین; MHC, myosin heavy chain; Gas, gastrocnemius muscle; Sol, soleus muscle; SEN, senescence; YA, young adult; MAFbx, muscle atrophy F-boxSarcopenia; Fast twitch; Hybrid fiber; Fiber type; MAFbx
Over-expression of PKGIα inhibits hypoxia-induced proliferation, Akt activation, and phenotype modulation of human PASMCs: The role of phenotype modulation of PASMCs in pulmonary vascular remodeling
Keywords: MHC، زنجیره سنگین میوزین; PASMCs, pulmonary artery smooth muscle cells; PKG, cGMP-dependent protein kinase; Ad-PKGIa, adenovirus containing the full-length cDNA of PKGIa; SM-α-actin, smooth muscle α-actin; MHC, myosin heavy chain; PVR, pulmonary vascular remodeling; AH, pulmonary
Cardiovascular and Systemic MicrovascularEffects of Anti-Vascular Endothelial Growth Factor Therapy for Cancer
Keywords: MHC، زنجیره سنگین میوزین; contrast echocardiography; VEGF; ventricular hypertrophyCEU, contrast-enhanced ultrasound; LV, left ventricle/ventricular; mAb, monoclonal antibody; MBF, microvascular blood flow; MBV, microvascular blood velocity; MHC, myosin heavy chain; PAS, periodic a
Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system
Keywords: MHC، زنجیره سنگین میوزین; EMB, embryonic body wall muscle isoform of myosin heavy chain; Mhc, myosin heavy chain; S1, proteolytic subfragment-1 of myosin; TEV, tobacco etch virusMyosin; Drosophila melanogaster; Histidine tag; Transgenic expression; Indirect flight muscles
The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes
Keywords: MHC، زنجیره سنگین میوزین; DZ, dizygotic; GEE, generalised estimating equation; MHC, myosin heavy chain; MZ, monozygotic; OGTT, oral glucose tolerance test; PGC, peroxisome proliferator-activated receptor γ coactivators; Rd, glucose disposal rate; SNP, single-nucleotide polymorphis
Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis
Keywords: MHC، زنجیره سنگین میوزین; PAP, phosphatidic acid phosphatase; LPP, lipid phosphate phosphatase; PPAR, peroxisome proliferator-activated receptor; PGC-1α, PPARγ coactivator 1α; ERR, estrogen related receptor; TG, triglyceride; FAO, fatty acid oxidation; MHC, myosin heavy chain; rtT
MicroRNAs in cardiac disease
Keywords: MHC، زنجیره سنگین میوزین; Dgcr8, DiGeorge syndrome critical region 8; LVAD, left ventricular assist device; MHC, myosin heavy chain; PTU, propyl-thiouracil; miR, microRNA; pre-miR, precursor miR; pri-miR, primary nuclear miR; RISC, RNA-induced silencing complex
A Proteomic Study of Myosin II Motor Proteins during Tumor Cell Migration
Keywords: MHC، زنجیره سنگین میوزین; MHC, myosin heavy chain; CK-II, casein kinase II; RLC, regulatory light chain; PKC, protein kinase C; EGF, epidermal growth factor; siRNA, small inhibitory RNA; LC-MS/MS, liquid chromatography–tandem mass spectrometry; EIC, extracted ion chromatogram; CIP
Stability of major allergen tropomyosin and other food proteins of mud crab (Scylla serrata) by in vitro gastrointestinal digestion
Keywords: MHC، زنجیره سنگین میوزین; DAB, 3,3′-diaminobenzindin tetrahydrochloride; GI, gastrointestinal; HRP, horseradish peroxidase; MHC, myosin heavy chain; SDS–PAGE, SDS–polyacrylamide gel electrophoresis; SIF, simulated intestinal fluid; SGF, simulated gastric fluid; TBST, Tris-buffered
Skeletal muscle: Energy metabolism, fiber types, fatigue and adaptability
Keywords: MHC، زنجیره سنگین میوزین; AMPK, AMP-dependent protein kinase; [Ca2+]i, cytosolic free Ca2+ concentration; Cr, creatine; MAPK, mitogen-activated protein kinase; MHC, myosin heavy chain; PCr, phosphocreatine; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α; P
Myocardial Remodeling Is Controlled by Myocyte-Targeted Gene Regulation of Phosphodiesterase Type 5
Keywords: MHC، زنجیره سنگین میوزین; cyclic GMP; heart failure; phosphodiesterase-5; pressure overload; protein kinase G; transgenic mouse modelscGMP, cyclic guanosine monophosphate; DOX, doxycycline; ECM, extracellular matrix; LV, left ventricular; MHC, myosin heavy chain; PDE, phosphodiest
Advanced age-related denervation and fiber-type grouping in skeletal muscle of SOD1 knockout mice
Keywords: MHC، زنجیره سنگین میوزین; AChR, acetylcholine receptor; ATB, anterior tibialis muscle; COX, cytochrome c oxidase; EDL, extensor digitorum longus muscle; GPX, glutathione peroxidase; GTN, gastrocnemius muscle; MHC, myosin heavy chain; MT, metallothionein; MTF-1, metal-induced trans
Regulatory mechanisms in lymphatic vessel contraction under normal and inflammatory conditions
Keywords: MHC، زنجیره سنگین میوزین; SM, smooth muscle; MHC, myosin heavy chain; MLC, myosin light chain; MLCK, myosin light chain kinase; MLCP, myosin light chain phosphatase; TM, tropomyosin; CaD, caldesmon; ERK, extracellular regulated kinase; Tn, troponin; TXA2, thromboxane A2; PAR2, pro
FAK regulates cardiomyocyte survival following ischemia/reperfusion
Keywords: MHC، زنجیره سنگین میوزین; AKT, RAC-alpha serine/threonine-protein kinase; ERK1/2, extracellular signal-regulated kinase 1/2; FN, fibronectin; GFP, green fluorescent protein; IκBα, NF-kappa-B inhibitor alpha; MHC, myosin heavy chain; MLC2V, myosin light chain-2V; NF-κB, nuclear fac
Contribution of cathepsins B, L and D to muscle protein profiles correlated with texture in rainbow trout (Oncorhynchus mykiss)
Keywords: MHC، زنجیره سنگین میوزین; DMSO, dimethyl sulfoxide; DTT, dithiothreitol; EDTA, ethylenediaminetetraacetic acid; GP, glycogen phosphorylase; MALDI–ToF, matrix-assisted laser desorption ionisation–time of flight; MHC, myosin heavy chain; MLC, myosin light chain; MS, mass spectrometr
Genomics, Transcriptional Profiling, and Heart Failure
Keywords: MHC، زنجیره سنگین میوزین; genomics; transcription; heart failureDNA, deoxyribonucleic acid; EMB, endomyocardial biopsy; GWAS, genome-wide association studies; HF, heart failure; MHC, myosin heavy chain; miRNA, microribonucleic acid; mRNA, messenger ribonucleic acid; RNA, ribonucle
Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics
Keywords: MHC، زنجیره سنگین میوزین; FHC, Familial hypertrophic cardiomyopathy; RLC, Regulatory light chain; MHC, Myosin heavy chain; Tg, Transgenic; NTg, Non-transgenic.Motility assay; ATPase; RLC; Optical trapping; FHC; Calcium binding site
Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia
Keywords: MHC، زنجیره سنگین میوزین; cyt b, cytochrome b; GFP, green fluorescent protein; HkEC, sublethal heat-killed Escherichia coli; LPS, lipopolysaccharide; NF-κB, nuclear factor-κB; MHC, myosin heavy chain; NO, nitric oxide; NOS, nitric oxide synthase; NRF, nuclear respiratory factors;
CELF-mediated alternative splicing is required for cardiac function during early, but not later, postnatal life
Keywords: MHC، زنجیره سنگین میوزین; CUG-BP1, CUG binding protein 1; ETR-3, ELAV-type RNA binding protein 3; CELF, CUG-BP and ETR-3-like factor; MHC, myosin heavy chain; cTNT, cardiac troponin T; CaMK, Ca2+/calmodulin-dependent kinase; LVESD, left ventricular end systolic dimension; PWS, pos
The Role of the N-Terminus of the Myosin Essential Light Chain in Cardiac Muscle Contraction
Keywords: MHC، زنجیره سنگین میوزین; ELC, essential light chain; Tg, transgenic; Tg-WT, human ventricular ELC wild type; Tg-Δ43, 43-amino-acid N-terminal truncation mutant; MHC, myosin heavy chain; MLC, myosin light chain; RLC, regulatory light chain; huELCv, human ventricular ELC; FHC, fami
The DH-PH Region of the Giant Protein UNC-89 Activates RHO-1 GTPase in Caenorhabditis elegans Body Wall Muscle
Keywords: MHC، زنجیره سنگین میوزین; GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; MBP, maltose-binding protein; MHC, myosin heavy chain; GFP, green fluorescent proteinC. elegans; muscle; GEF; rho; UNC-89
Sexual dimorphism of murine masticatory muscle function
Keywords: MHC، زنجیره سنگین میوزین; ADM, anterior deep masseter; DAPI, 4′-6-diamidino-2-phenylindole; dP/dt, rate of force generation; FSHD, facioscapularhumeral muscular dystrophy; Lo, optimum muscle length; MHC, myosin heavy chain; Po, maximum isometric tetanic force; Pt, maximum isometri
Cardiac Contractility Modulation Electrical Signals Improve Myocardial Gene Expression in Patients With Heart Failure
Keywords: MHC، زنجیره سنگین میوزین; CCM, cardiac contractility modulation; DNA, deoxyribonucleic acid; HF, heart failure; MHC, myosin heavy chain; MLHFQ, Minnesota Living with Heart Failure Questionnaire; RNA, ribonucleic acid; SERCA-2a, sarcoplasmic reticulum calcium adenosine triphosphata
Myocardial Gene Expression in Heart Failure Patients Treated With Cardiac Resynchronization Therapy: Responders Versus Nonresponders
Keywords: MHC، زنجیره سنگین میوزین; BNP, brain natriuretic peptide; CRT, cardiac resynchronization therapy; HF, heart failure; LV, left ventricle/ventricular; MHC, myosin heavy chain; mRNA, messenger ribonucleic acid; Nt-proBNP, N-terminal part of the pro-brain natriuretic peptide; PLN, pho
Blockade of NF-κB Using IκBα Dominant-Negative Mice Ameliorates Cardiac Hypertrophy in Myotrophin-Overexpressed Transgenic Mice
Keywords: MHC، زنجیره سنگین میوزین; NF-κB, nuclear factor-κB; HF, heart failure; MHC, myosin heavy chain; LV, left ventricular; TNF-α, tumor necrosis factor-alpha; WT, wild type; FSh, fractional shortening; ANF, atrial natriuretic factor; MLC2, myosin light chain 2; IL, interleukin; MCP-1,
Tumor necrosis factor-α exerts pro-myogenic action in C2C12 myoblasts via sphingosine kinase/S1P2 signaling
Keywords: MHC، زنجیره سنگین میوزین; TNFα, tumor necrosis factor-α; SphK, sphingosine kinase; S1P, sphingosine 1-phosphate; MHC, myosin heavy chain; siRNA, short interfering RNA; SKI, sphingosine kinase inhibitor; WTSphK1, wild-type SphK1; DNSphK1, catalytically inactive SphK1Tumor necrosis
Phenotypic behavior of C2C12 myoblasts upon expression of the dystrophy-related caveolin-3 P104L and TFT mutants
Keywords: MHC، زنجیره سنگین میوزین; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; HS, horse serum; MHC, myosin heavy chain; NFATC, nuclear factor of activated T-cells; IL-4, Interleukin 4Caveolin 3; Dystrophy; AKT; Follistatin; NFATC2; IL-4; Murf-1; Atrogin
Recipient Age Determines the Cardiac Functional Improvement Achieved by Skeletal Myoblast Transplantation
Keywords: MHC، زنجیره سنگین میوزین; EF, ejection fraction; FAC, fractional area change; FS, fractional shortening; MHC, myosin heavy chain; MI, myocardial infarction; SCF, stem cell factor; SKMC, skeletal myoblast
An Unusual Transduction Pathway in Human Tonic Smooth Muscle Myosin
Keywords: MHC، زنجیره سنگین میوزین; CD, circular dichroism; Dc, Dictyostelium discoideum; DOPE, discrete optimized protein energy; ELC, essential light chain of myosin; kET, electron transfer rate; KSV, Stern-Volmer quenching constant; MHC, myosin heavy chain; MYH11, human smooth muscle myo
EAST and Chromator control the destruction and remodeling of muscles during Drosophila metamorphosis
Keywords: MHC، زنجیره سنگین میوزین; Chro, Chromator; GFP, green fluorescent protein; APF, after puparium formation; PPT, prepupal–pupal transition; MHC, myosin heavy chain; DEOM, dorsal external oblique muscle; DIOM, dorsal internal oblique muscle; TDIOM, temporary dorsal internal oblique m
A Variable Domain near the ATP-Binding Site in Drosophila Muscle Myosin Is Part of the Communication Pathway between the Nucleotide and Actin-binding Sites
Keywords: MHC، زنجیره سنگین میوزین; MHC, myosin heavy chain; EMB, embryonic body wall muscle; IFI, indirect flight muscle isoform; IFM, indirect flight muscle; eda-deac ADP, coumarin ADP; cATP, caged ATP; S1, subfragment 1muscle; myosin; Drosophila; kinetics; nucleotides
Alternative S2 Hinge Regions of the Myosin Rod Differentially Affect Muscle Function, Myofibril Dimensions and Myosin Tail Length
Keywords: MHC، زنجیره سنگین میوزین; MHC, myosin heavy chain; IFM, indirect flight muscle; TDT, tergal depressor of the trochanter; S1, myosin subfragment 1; S2, myosin subfragment 2; LMM, light meromyosin; HMM, heavy meromyosin; IFI-15b, indirect flight muscle isoform of MHC with embryonic
Heterogeneous PrPC metabolism in skeletal muscle cells
Keywords: MHC، زنجیره سنگین میوزین; CJD, Creutzfeldt–Jacob disease; CNS, central nervous system; DIV, days in vitro; DMEM, Dulbecco-modified Eagle’s medium; GPI, glycosylphosphatidylinositol; IB, inclusion-body; Mab, monoclonal antibody; MHC, myosin heavy chain; Pab, polyclonal antibody; PB