کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2945206 1577125 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Right Heart Adaptation to Pulmonary Arterial Hypertension : Physiology and Pathobiology
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Right Heart Adaptation to Pulmonary Arterial Hypertension : Physiology and Pathobiology
چکیده انگلیسی

Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right ventricular (RV) function. Although pulmonary load is an important determinant of RV systolic function in PAH, there remains a significant variability in RV adaptation to pulmonary hypertension. In this report, the authors discuss the emerging concepts of right heart pathobiology in PAH. More specifically, the discussion focuses on the following questions. 1) How is right heart failure syndrome best defined? 2) What are the underlying molecular mechanisms of the failing right ventricle in PAH? 3) How are RV contractility and function and their prognostic implications best assessed? 4) What is the role of targeted RV therapy? Throughout the report, the authors highlight differences between right and left heart failure and outline key areas of future investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 62, Issue 25, Supplement, 24 December 2013, Pages D22–D33
نویسندگان
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