Interplay between I308 and Y310 residues in the third repeat of microtubule-binding domain is essential for tau filament formation
Keywords: Tau; Microtubule-binding domain; Tyrosine residue; Isoleucine residue; Filament formation; C–H⋯π interaction3RMBD, three-repeated MBD; 4RMBD, four-repeated MBD; AD, Alzheimer’s disease; CD, circular dichroism; His, histidine; EM, electron microscopy; MBD,