Identification of novel mPGES-1 inhibitors through screening of a chemical library
Keywords: mPGES-1; Screening; Inhibitors; Anti-inflammatory drug; Modeling;
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Immunohistochemical Expression of COX-2, mPGES and EP2 Receptor in Normal and Reactive Canine Bone and in Canine Osteosarcoma
Keywords: canine osteosarcoma; COX-2; EP2 receptor; mPGES-1;
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors
Keywords: Triazole-based inhibitors; In silico screening; mPGES-1; 5-Lipoxygenase;
A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold
Keywords: Inflammation; Arachidonic acid cascade; SAR; mPGES-1; 5-LO
Trisubstituted ureas as potent and selective mPGES-1 inhibitors
Keywords: mPGES-1; PGE synthase; Inflammation; Prostaglandins; Trisubstituted urea
Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells
Keywords: RhoA GTPase; mPGES-1; Epithelial cancer cells
Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice
Keywords: mPGES-1; Metastatic bone cancer; Bone destruction; Bone cancer pain
The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model
Keywords: Prostaglandin E2; MPGES-1; COX-2; Endometriosis; Angiogenesis
Microsomal Prostaglandin E Synthase-1 Inhibits PTEN and Promotes Experimental Cholangiocarcinogenesis and Tumor Progression
Keywords: Cancer Cell Signaling; Biliary Tract Cancer; Bile Duct; LiverBrdU, bromodeoxyuridine; CHIP, chromatin immunoprecipitation; COX, cyclooxygenase; EGR-1, early growth response-1; EGFR, epidermal growth factor receptor; GFP, green fluorescent protein; mPGES-1
Prostaglandin E2 Signaling and Bacterial Infection Recruit Tumor-Promoting Macrophages to Mouse Gastric Tumors
Keywords: Stomach Cancer; Tumor Promotion; Bacterial Infection; COX-2; cyclooxygenase-2; Gan; Gastric neoplasia; GF; germfree; IL-1β; interleukin-1β; IL-6; interleukin-6; LPS; lipopolysaccharide; mPGES-1; microsomal prostaglandin E synthase-1; NF-κB; nuclear fac
Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1
Keywords: mPGES-1; Inhibitor; Biarylimidazole; PGE2; Inflammation
mPGES-1 as a target for cancer suppression : A comprehensive invited review “Phospholipase A2 and lipid mediators”
Keywords: mPGES-1; Inflammation; PGE2; Cancer; mPGES-1 inhibitor
mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice
Keywords: mPGES-1; Anginogenesis; Cancer; Bone marrow derived cells
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models
Keywords: Prostaglandin E synthase; mPGES-1; Knockout mice; PGE2; Inflammation
Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages
Keywords: AA; arachidonic acid; ChIP; chromatin immunoprecipitation; COX; cyclooxygenase; Egr-1; early growth response 1; LUC; luciferase; PG; prostaglandin; mPGES-1; microsomal Prostaglandin E synthase 1; cPGES; cytosolic Prostaglandin E synthase; PGHS; Prostaglan
Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway
Keywords: N-Arachidonoyl-dopamine; COX-2; p38 MAPK; mPGES-1; Endothelial cells
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors
Keywords: mPGES-1; Inhibitors; Phenanthrene imidazole; Activity; Pharmacokinetic
Pharmacoinformatics approach for mPGES-1 in anti-inflammation by 3D-QSAR pharmacophore mapping
Keywords: Inflammation; mPGES-1; Azaphenanthrenone derivatives; HypoGen technique; Pharmacophore;
Expression of cyclooxygenase-1/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE2 in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells
Keywords: microglia; hypoxia; COX-1/-2; mPGES-1; EP2 receptor antagonist; PGE2; AA; arachidonic acid; AMC; amoeboid microglial cells; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; COX-1; cyclooxygenase-1; COX-2; cyclooxygenase-2; cPGES; cytosol
mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice
Keywords: Prostaglandins; COX-2; mPGES-1; Hypothalamus; Brainstem
Microsomal prostaglandin E synthase-1 and blood pressure regulation
Keywords: mPGES-1; blood pressure; collecting duct; nitric oxide; angiotensin II
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
Keywords: mPGES-1; PGE2; Inflammation; Prostanoid
Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages
Keywords: LXR; mPGES-1; PGE2; LPS; Macrophages;
Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation
Keywords: Cyclooxygenase; mPGES-1; Carrageenin pleurisy; Parathymic lymph node; Leukocyte transmigration
Clinical significance of prostaglandin E synthase expression in gastric cancer tissue
Keywords: COX-2; cPGES; Gastric cancer; mPGES-1; mPGES-2
c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1)
Keywords: c-Fos; mPGES-1; COX-2; PGE2; LPS; Inflammation; Sickness behavior; Nucleus tractus solitarius; Hypothalamus; Amygdala
IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer
Keywords: NSCLC; IL-4; COX-2; PGE2; mPGES-1; 15-PGDH
Carcinogenesis in Mouse Stomach by Simultaneous Activation of the Wnt Signaling and Prostaglandin E2 Pathway
Keywords: APC; adenomatous polyposis coli; BrdU; bromodeoxyuridine; COX-2; cyclooxygenase-2; mPGES-1; microsomal prostaglandin E synthase-1; MVD; microvessel density; PGE2; prostaglandin E2; PPARδ; peroxisome proliferator-activated receptor δ; SPEM; spasmolytic p
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis
Keywords: Prostaglandin; PGE2; mPGES-1; Protein structure; Molecular modeling; Mutagenesis; Binding affinity;
IL-1β Treatment Does not Co-ordinately Up-regulate mPGES-1 and COX-2 mRNA Expression, but Results in Higher Degree of Cellular and Intracellular Co-localization of their Immunoreactive Proteins in Human Placenta Trophoblast Cells
Keywords: COX-2; mPGES-1; PGE2; Cytokines; Parturition; Trophoblast
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts
Keywords: mPGES-1; PGE2; PPARγ; PGF2α; PKC; p38 MAP kinase; Gingival fibroblasts; Inflammatory mediators
Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases
Keywords: Prostaglandin; PGE2; COX; PGES; mPGES-1; mPGES-2; cPGES; Inflammation; Arthritis
Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues
Keywords: PLA2; phospholipase A2; sPLA2; secretory PLA2; PGE2; prostaglandin E2; COX; cyclooxygenase; mPGES-1; microsomal PGE synthase-1; RT-PCR; recerse transcriptase-polymerase chain reaction; VSMC; vascular smooth muscle cells; Phospholipase A2; Immunohistochemi
On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens
Keywords: Carbaprostacyclin; Co-localization; Hydroxyprostaglandin; Immunohistochemistry; Real-time PCR; Liquid chromatography-mass spectrometry; COX; cyclooxygenase; CYP; cytochrome P450; ER; endoplasmic reticulum; 6,9α-Methylene-PGI2; carbaprostacyclin; 9α,11α