Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; BHA, butylated hydroxyanisol; DMSO, dimethyl sulfoxide; FITC, fluorescein isothiocyanate; H2O2, hydrogen peroxide; ΔΨm, mitochondrial membrane potential; MPTP, mitochondrial permeability transition pore; NAC, N-acetyl cysteine; NAO, nonyl acridine orange;
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Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ROS, reactive oxygen species; mtDNA, mitochondrial DNA; ETC, electron transport chain; ER, endoplasmic reticulum; MCU, mitochondrial calcium uniporter; mPTP, mitochondrial permeability transition pore; VDAC, voltage dependent anion-selective channel; GA,
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ischemia/reperfusion; myocardial infarction; STEMI; therapyAAR, area at risk; CMR, cardiac magnetic resonance; I/R, ischemia/reperfusion; LVEF, left ventricular ejection fraction; MPTP, mitochondrial permeability transition pore; MVO, microvascular obstru
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; APX, ascorbate peroxidase; AsA, ascorbic acid; CAT, catalase; CsA, cyclosporine A; DHR123, dihydrohodamine123; DPI, diphenyl iodonium; FA, fusaric acid; H2O2, hydrogen peroxide; MDA, malondialdehyde; MPTP, mitochondrial permeability transition pore; NO, n
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; MPTP, mitochondrial permeability transition pore; CYPD, cyclophilin D; HFD, high fat diet; LFD, low fat diet; WT, wild type; KO, knockout; CSA, cyclosporin A; BKA, bongkrekic acid; O2, superoxide; [3H]-2-DOG, [3H]-2-deoxyglucose; Rg′, rate of glucose tran
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; mPTP, mitochondrial permeability transition pore; PKG, protein kinase G; PostC, postconditioning; RIC, remote ischemic conditioning; STEMI, ST-segment elevation acute myocardial infarctionReperfusion injury; Myocardial infarction; Remote ischemic conditio
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; atrophy; COPD; exercise; mitochondria; skeletal muscleCOX, complex IV activity; FoxO, forkhead box class O; GOLD, Global Initiative for Chronic Obstructive Lung Disease; mPTP, mitochondrial permeability transition pore; mtDNA, mitochondrial DNA; mtROS, mi
Identification of EFHD1 as a novel Ca2+ sensor for mitoflash activation
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; mPTP, mitochondrial permeability transition pore; fMPT, mitoflash-related mitochondrial permeability transition; ROS, reactive oxygen species; cpYFP, circularly permuted yellow fluorescent protein; RNAi, RNA interferenceMitochondria; Mitochondrial flash (
Mitochondrial translocator protein (TSPO): From physiology to cardioprotection
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; AIF, apoptosis inducing factor; ANT, adenine nucleotide translocase; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; IMAC, inner membrane anion channel; mPTP, mitochondrial permeability transition pore; PBR, peripheral benzodiazepine receptors;
Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; Bax, Bcl-2-associated X protein; Bcl-2, B-cell leukemia-2; EEG, electroencephalogram; I/R, ischemia–reperfusion; MAP, mean arterial blood pressure; MMP, mitrochondrial membrane potential; MPTP, mitochondrial permeability transition pore; mtDNA, mitochondr
Combined effect of G3139 and TSPO ligands on Ca2+-induced permeability transition in rat brain mitochondria
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; VDAC; TSPO; Mitochondria; Permeability transition pore; PK11195; G3139ANT, adenine nucleotide translocase; PK11195, 1-(2-Chlorophenyl-N-methylpropyl)-3-isoquinolinecarboxamide; PPIX, protoporphyrin IX; mPTP, mitochondrial permeability transition pore; RBM
KB-R7943, a plasma membrane Na+/Ca2+ exchanger inhibitor, blocks opening of the mitochondrial permeability transition pore
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; NCXrev, reverse-mode of NCX; mPTP, mitochondrial permeability transition pore; CRC, mitochondrial calcium retention capacity; ΔΨm, mitochondrial membrane potential; ECM, extracellular medium; MAB, mitochondria assay buffer; KRHB, Krebs–Ringers-HEPES-bicar
Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ANT, adenine nucleotide transporter; BLM, black-lipid membrane; CsA, cyclosporin A; CyP-D, cyclophilin D; DCCD, dicyclocarbodiimide; DOC-Na, sodium deoxycholate; mPTP, mitochondrial permeability transition pore; PKA, protein kinase A; RLM, rat liver mitoc
Ultra-violet B (UVB)-induced skin cell death occurs through a cyclophilin D intrinsic signaling pathway
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; Cyp-D, cyclophilin D; Cs-A, cyclosporine A; H2O2, hydrogen peroxide; mPTP, mitochondrial permeability transition pore; ROS, reactive oxygen species; NAC, N-acetyl cysteine; TNF-α, tumor-necrosis factor-α; UVB, ultraviolet BUVB radiation; Cyclophilin D; Sk
Ischemia–reperfusion induces myocardial infarction through mitochondrial Ca2+ overload
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; PLN, phospholamban; SR, sarcoplasmic reticulum; MI, myocardial infarction; anti-, antibody to; mPTP, mitochondrial permeability transition pore; AIF, apoptosis-inducing factor; CsA, cyclosporine A; SfA, sanglifehrin-A; LAD, left anterior descending corona
The ribonuclease/angiogenin inhibitor is also present in mitochondria and nuclei
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; RI, RNase inhibitor; RNase, ribonuclease; ROS, reactive oxygen species; PBS, Phosphate Buffered Saline; PBS GS, PBS containing 0.2% Gelatin and 0.075% Saponin; MPTP, mitochondrial permeability transition pore; ANT, ADP/ATP Translocase; SDS–PAGE, polyacryl
Is mPTP the gatekeeper for necrosis, apoptosis, or both?
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; CsA; cyclosporine A; ROS; reactive oxygen species; MPT; mitochondrial permeability transition; MOMP; mitochondrial outer membrane permeabilization; iMACs; inhibitors of MAC; mPTP, mitochondrial permeability transition pore; MAC, mitochondrial apoptosis-in
The role of mitochondrial membrane potential in ischemic heart failure
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; CcO, cytochrome c oxidase; ROS, reactive oxygen species; MPTP, mitochondrial permeability transition pore; I/R, ischemia/reperfusionHeart ischemia/reperfusion; Cytochrome c oxidase; Mitochondrial membrane potential; Reactive oxygen species; Protein phosph
Transient mitochondrial permeability transition pore opening after neonatal cardioplegic arrest
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; 17; 20; 31; 38CS, citrate synthase; CsA, cyclosporin A; EGTA, ethyleneglycol-bis-(β-aminoethylether)-N,N,N′,N′-tetraacetic acid; KHB, Krebs–Henseleit buffer; MOPS, 3-morpholinopropane-1-sulfonic acid; MPTP, mitochondrial permeability transition pore; OAA,
Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylation
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; mPTP, mitochondrial permeability transition pore; ER, endoplasmic reticulum; UPR, unfolded protein response; PKR, protein kinase RNA; TUDCA, tauroursodeoxycholic acid; ROS, reactive oxygen species; GSK3β, glycogen synthase kinase-3β; PS, peak shortening;
Biochemistry and physiology of mitochondrial ion channels involved in cardioprotection
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ROS, reactive oxygen species; ΔΨm, mitochondrial membrane potential; mitoKATP channel, mitochondrial ATP-sensitive K+ channel; mitoKCa channel, mitochondrial Ca2+-activated K+ channel; mPTP, mitochondrial permeability transition pore; RuR, ruthenium red;
Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; Aβ, amyloid beta; AD, Alzheimer's disease; mPTP, mitochondrial permeability transition pore; cyp D, cyclophilin D; VDAC, voltage-dependent anion channel; ANT, adenine nucleotide translocator; CSA, cyclosporine A; ROS, reactive oxygen speciesAmyloid beta;
Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ARA, arachidonic acid; CsA, cycolosporin A; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; MPTP, mitochondrial permeability transition pore; PUFA, polyunsaturated fatty acid; VDAC, voltage-dependant anion channelCardiac; Eicosapentaenoic acid; Doc
Prevention and Treatment of Microvascular Obstruction-Related Myocardial Injury and Coronary No-Reflow Following Percutaneous Coronary Intervention: A Systematic Approach
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; no-reflow; microvascular obstruction; coronary intervention; distal embolization; cardioprotectionACC, American College of Cardiology; AHA, American Heart Association; MPTP, mitochondrial permeability transition pore; MVO, microvascular obstruction; PCI,
SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ATP-DR, ATP depletion–recovery; DPBS, Dulbecco's phosphate-buffered saline; EGFP, enhanced green fluorescent protein; IR, ischemia–reperfusion; MPTP, mitochondrial permeability transition pore; ROS, reactive oxygen species; SOD, superoxide dismutaseATP de
Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ANT, adenine nucleotide translocase; CPT, camptothecin; MPTP, mitochondrial permeability transition pore; ΔΨm, mitochondrial membrane potentialCamptothecin; Adenine nucleotide translocase 3; Apoptosis; Hepatoma QGY7703 cell; Mitochondrial permeability tra
Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; HD, Huntington's disease; mPTP, mitochondrial permeability transition pore; CsA, cyclosporin AHuntington disease; Mitochondria; Calcium; Mitochondrial Membrane potential; Permeability transition pore
Cholestane-3β,5α,6β-triol-induced reactive oxygen species production promotes mitochondrial dysfunction in isolated mice liver mitochondria
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ROS, reactive oxygen species; ETC, electron transfer chain; mPTP, mitochondrial permeability transition pore; ΔΨm, mitochondrial membrane potential; Triol, cholestane-3β,5α,6β-triol; 7β-OH, 7β-hydroxycholesterol; 25-OH, 25-hydroxycholesterol; 7-keto, 7-ke
Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ANT, adenine nucleotide transporter; GAPDH, glyceraldehydes-3-phosphate dehydrogenase; MPTP, mitochondrial permeability transition pore; PBR, peripheral-type benzodiazepine receptor; TSPO, 18 kDa translocator protein; VDAC, voltage dependent anion channel
Effect of progesterone and its synthetic analogues on the activity of mitochondrial permeability transition pore in isolated rat liver mitochondria
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ANT, adenine nucleotide translocase; BuOOH, t-butylhydroperoxide; Buterol, 17a-acetoxy-3b-butanoyloxy-6-methyl-pregna-4,6-diene-20-on; CAT, carboxyatractyloside; MPA, medroxyprogesterone acetate; MPTP, mitochondrial permeability transition pore; NEM, N-et
Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; GSH, reduced glutathione; GSHME, glutathione monoethyl ester; MPTP, mitochondrial permeability transition pore; DMSO, dimethyl sulfoxide; PBN, phenyl tert-butylnitr
Neuroprotection by rasagiline in thiamine deficient rats
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; GFAP, Glial fibrillary acidic protein; HE, Hematoxylin and eosin stains; IP, Intraperitoneal; MAO, Monoamine oxidase; MPTp, Mitochondrial permeability transition pore; SC, Subcutaneous; SHR, Spontaneously hypertensive rats; TD, Thiamine deficiency; WKS, W
What is the mitochondrial permeability transition pore?
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; ANT, adenine nucleotide translocase; BKA, bongkrekic acid; CAT, carboxyatractyloside; CsA, cyclosporin A; CyP, cyclophilin; HK, hexokinase; IMM, inner mitochondrial membrane; MPTP, mitochondrial permeability transition pore; NEM, N-ethylmaleimide; PAO, ph
Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; AD, Alzheimer's disease; CAD, Cath.a differentiated; C2-ceramide, N-acetyl-sphingosine; mPTP, mitochondrial permeability transition pore; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MTT, 3-(4,5-dimethyl-thiazol-2yl)-2,5-diphenyltetrazolium bromide
Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; MMP, mitochondrial membrane potential; MPTP, mitochondrial permeability transition pore; PBR, peripheral-type benzodiazepine receptor/translocator protein (18 kDa); VDSC, voltage-gated sodium channel; [Ca2+]i, intracellular Ca2+ levelVinpocetine; Peripher
Cardiopulmonary Bypass with Cardioplegic Arrest Activates Protein Kinase C in the Human Myocardium
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; AV, annexin V; CABG, coronary artery bypass grafting; CP, cardioplegic arrest; CPB, cardiopulmonary bypass; I/R, ischemia–reperfusion; MPTP, mitochondrial permeability transition pore; PI, propium iodide; PKC, protein kinase C
Minocycline, a possible neuroprotective agent in Leber’s hereditary optic neuropathy (LHON): Studies of cybrid cells bearing 11778 mutation
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; LHON, Leber’s hereditary optic neuropathy; mPTP, mitochondrial permeability transition pore; ROS, reactive oxygen species; CsA, cyclosporin A; AcCh, acetylcholine; TG, thapsigargin; TMRM, tetramethyl rhodamine methyl ester; MC, minocycline; MTT, 3-[4,5-di
Involvement of endoplasmic reticulum in hepatitis B virus replication
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; HBV, hepatitis B virus; HBx, hepatitis B x protein; MPTP, mitochondrial permeability transition pore; PyK2, proline-rich tyrosine kinase-2; ER, endoplasmic reticulum; PCR, polymerase chain reaction; CsA, cyclosporine A; CPA, cyclopiazonic acid; RyR, ryano
Arachidonic acid induces specific membrane permeability increase in heart mitochondria
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; FFA, free fatty acids; AA, arachidonic acid; ANT, adenine nucleotide translocator; Atr, atractyloside; CsA, cyclosporin A; ROS, reactive oxygen species; MPTP, mitochondrial permeability transition pore; MPT, mitochondrial permeability transition; ΔΨ, tran
Proapoptotic BCL-2 family members and mitochondrial dysfunction during ischemia/reperfusion injury, a study employing cardiac HL-1 cells and GFP biosensors
Keywords: mPTP، نفوذ پذیری میتوکندری منافذ انتقال; sI/R, simulated ischemia/reperfusion; ROS, reactive oxygen species; MPTP, mitochondrial permeability transition pore; TMRM, tetramethylrhodamine methyl ester; CM-DCF, chloromethyl-dichlorofluorescein; KH, Krebs–Henseleit; FP, fluorescent proteinIschemia;