کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2197236 | 1550956 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats
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کلمات کلیدی
ANT, adenine nucleotide transporterVDAC, Voltage dependent anion channelPBR, peripheral-type benzodiazepine receptorGAPDH, glyceraldehydes-3-phosphate dehydrogenase - GAPDH، glyceraldehydes-3-phosphate dehydrogenasemPTP, mitochondrial permeability transition pore - mPTP، نفوذ پذیری میتوکندری منافذ انتقال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We examined the effect of ovariectomy, with and without estradiol treatment, on 18 kDa translocator protein (TSPO) gene expression and its binding density in the uterus and kidney of rats. Ovariectomy causes a significant decrease in uterine, but not renal TSPO binding density, while estradiol treatment of ovariectomized rats restored TSPO binding density in the uterus. These TSPO density levels did not correlate with steady state or new RNA transcription. Our in vivo study suggests that estradiol is responsible for the maintenance of uterine TSPO density via transcriptional mechanisms. Our in vivo study also suggests that in the kidney estradiol appears to operate via post-transcriptional mechanisms to maintain TSPO density.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 307, Issues 1–2, 13 August 2009, Pages 43–49
Journal: Molecular and Cellular Endocrinology - Volume 307, Issues 1–2, 13 August 2009, Pages 43–49
نویسندگان
Caroline Mazurika, Leo Veenman, Ronit Weizman, Miri Bidder, Svetlana Leschiner, Idit Golani, Ilana Spanier, Gary Weisinger, Moshe Gavish,