A study of ACE, eNOS and MTHFR association with psoriasis in Pakistani population
Keywords: ACE; eNOS; MTHFR; Psoriasis; Pakistani population;
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The association between donor genetic variations in one-carbon metabolism pathway genes and hepatitis B recurrence after liver transplantation
Keywords: HBV; hepatitis B virus; HBIG; hepatitis B immunoglobulin; SNP; single nucleotide polymorphisms; DNA; deoxyribonucleic acid; HCC; hepatocellular carcinoma; MTHFR; Methylene Tetrahydrofolate Reductase; MTR; 5-methyltetrahydrofolate-homocysteine methyltransf
Genetic association of AKR1B1 gene polymorphism rs759853 with diabetic retinopathy risk: A meta-analysis
Keywords: ORs; Crude odds ratios; DR; diabetic retinopathy; DM; diabetes mellitus; T1DM; type 1 DM; T2DM; type 2 DM; NOS; nitric oxide synthase; AKR1B1; aldo-keto reductase family 1, member B1; VEGF; vaseular endothelial growth factor; ACE; angiotensin-converting e
MTHFR C677T and A1298C polymorphisms may contribute to the risk of Parkinson's disease: A meta-analysis of 19 studies
Keywords: Parkinson's disease; Meta-analysis; MTHFR;
Identification of three novel loci of ALDH2 Gene for Serum Folate levels in a Male Chinese Population by Genome-Wide Association Study
Keywords: GWAS; genome-wide association studies; SNP; single-nucleotide polymorphisms; ALDH2; aldehyde dehydrogenase 2; ROS; reactive oxygen species; SPSS; Statistic Package for Social Science; KEGG; Kyoto Encyclopedia of Genes and Genomes; DAVID; The Database for
IsomiR processing during differentiation of myelogenous leukemic cell line K562 by phorbol ester PMA
Keywords: CML; chronic myelogenous leukemia; PMA; phorbol 12-myristate 13-acetate; NGS; next generation sequencing; TPM; trimmed per million; %; percentage; NET1; neuro-epithelial transforming gene 1; YARS; tyrosyl-tRNA synthetase; IPO7; importin 7; MTHFR; methylen
A direct isothermal amplification system adapted for rapid SNP genotyping of multifarious sample types
Keywords: Single nucleotide polymorphism; Isothermal amplification; Multifarious sample types; MTHFR; ALDH2;
Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review
Keywords: AAV; antineutrophil cytoplasmic antibody associated vasculitis; ACE; angiotensin-converting enzyme; Agt; angiotensin; ANCA; antineutrophil cytoplasmic antibody; AT1R; angiotensin II receptor type 1; AT2R; angiotensin II receptor type 2; CCL2; chemokine C-
Association of RFC1 A80G gene polymorphism with advanced maternal age in risk of Down syndrome
Keywords: DS; Down syndrome; NDJ; nondisjunction; MTHFR; methylenetetrahydrofolate reductase; MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase; MTRR; 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; RFC1; reduced folate carrier 1; IHEC
Genetic variations of MTHFR gene and their association with preterm birth in Korean women
Keywords: Preterm birth; MTHFR; Polymorphism; Korean women; Genetic association;
Influence of MTHFR C677T gene polymorphism in the development of cardiovascular disease in Egyptian patients with rheumatoid arthritis
Keywords: ANOVA; analysis of variance; CIs; confidence intervals; CIMT; carotid intima-media thickness; CVD; cardiovascular disease; CRP; C-reactive protein; DAS; Disease Activity Score; BMI; body mass index; ELISA; high-sensitivity enzyme-linked immunosorbent assa
Folate and microRNA: Bidirectional interactions
Keywords: 1CM; One-carbon metabolism; 5-MTHF; methyltetrahydrofolate; Aβ; amyloid-β protein; APP; amyloid precursor protein; DHFR; dihydrofolate reductase; MTHFR; methylenetetrahydrofolate reductase; MTR; methionine synthase; NAFLD; Non-alcoholic fatty liver dise
Serum folate, vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes: A meta-analysis
Keywords: Diabetic peripheral neuropathy; Type 2 diabetes mellitus; Folic acid; Vitamin B12; Serum; Meta-analysis; CI; confidence interval; CoA; coenzyme A; DPN; diabetic peripheral neuropathy; Hcy; homocysteine; HHcy; hyperhomocysteinemia; MTHFR; 10-methylenetetra
Is hyperhomocysteinemia a causal factor for heart failure? The impact of the functional variants of MTHFR and PON1 on ischemic and non-ischemic etiology
Keywords: Heart failure; Dilated cardiomyopathy; Ejection fraction; Homocysteine; MTHFR; PON1;
Associative role of TYMS6bpdel polymorphism and resulting hyperhomocysteinemia in the pathogenesis of preterm delivery and associated complications: A study from Northeast India
Keywords: PTD; preterm delivery; LBW; low birth weight; MTHFR; Methylene Tetrahydrofolate Reductase; TYMS; Thymidylate Synthase; IUD; intra uterine death; Del; deletion; Ins; insertion; MTHF; methylene tetrahydrofolate; UTI; urinary tract infection; UTR; untranslat
Archival ReportThe C677T Variant in MTHFR Modulates Associations Between Brain Integrity, Mood, and Cognitive Functioning in Old Age
Keywords: Age-related cognitive decline; Brain atrophy; Homocysteine; Late-life depression; MRI; MTHFR;
Null association of maternal MTHFR A1298C polymorphism with Down syndrome pregnancy: An updated meta-analysis
Keywords: Down syndrome; Methylenetetrahydrofolate reductase; MTHFR; A1298C; Homocysteine; Meta-analysis; Folate;
Riboflavin, MTHFR genotype and blood pressure: A personalized approach to prevention and treatment of hypertension
Keywords: Riboflavin; Methylenetetrahydrofolate reductase (MTHFR) genotype; Blood pressure; Hypertension; Hypertension-in-pregnancy; Personalized medicine; CVD; cardiovascular disease; EGRac; erythrocyte glutathione reductase activation coefficient; eNOS; endotheli
Polymorphisms of MTHFR, eNOS, ACE, AGT, ApoE, PON1, PDE4D, and Ischemic Stroke: Meta-Analysis
Keywords: Ischemic stroke; MTHFR; eNOS; ACE; AGT; ApoE; PON1; PDE4D;
B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke
Keywords: BDNF; Brain derived neurotrophic factor; CD; Control diet; FADD; Folic acid deficient diet; OGD; Oxygen glucose deprivation; Nrf-2; Nuclear factor (erythroid-derived 2)-like2; MTHFR; Methylenetetrahydrofolate reductase; SOD2; Superoxide dismutase 2; SD; S
The association between MTHFR gene C677T polymorphism and ALL risk based on a meta-analysis involving 17,469 subjects
Keywords: Acute lymphoblastic leukaemia; MTHFR; Polymorphism; Meta-analysis;
Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer
Keywords: Biomarker; Chemotherapy; Folic acid; MTHFR; Polymorphism;
Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in rheumatoid arthritis patients: Correlation with serum osteopontin levels and disease activity
Keywords: Rheumatoid arthritis; MTHFR; Osteopontin; Disease activity score;
Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis
Keywords: PVT; portal vein thrombosis; LC; liver cirrhosis; HCC; hepatocellular carcinoma; Hcy; homocysteine; HHcy; hyperhomocysteinemia; PTHR; prothrombin; FVL; Factor V Leyden; MTHFR; methylen-tetrahydrofolate reductase; Homocysteine; Hepatocellular carcinoma; Po
Association between premature ovarian failure, polymorphisms in MTHFR and MTRR genes and serum homocysteine concentration
Keywords: gene polymorphism; homocysteine; MTHFR; MTRR; premature ovarian failure
Role of MTHFR A1298C gene polymorphism in the etiology of prostate cancer: A systematic review and updated meta-analysis
Keywords: MTHFR; A1298C; Polymorphism; Prostate cancer; Meta-analysis
European Code against Cancer 4th Edition: Alcohol drinking and cancer
Keywords: IARC; International Agency for Research on Cancer; EU; European Union; RR; Relative risk; UADT; Upper aero digestive tract; ADH; Alcohol dehydrogenase; ALDH; Acetaldehyde dehydrogenase; MTHFR; Methylenetetrahydrofolate reductase; ER; Estrogen receptor; PR
Mthfr as a modifier of the retinal phenotype of Crb1rd8/rd8 mice
Keywords: CRB1; Homocysteine; Retina; rd8; MTHFR; Mouse; LCA; RP;
Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis
Keywords: Ischemic stroke; meta-analysis; MTHFR; polymorphism;
C667T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene and susceptibility to myocardial infarction: A systematic review and meta-analysis
Keywords: MTHFR; Polymorphism; C667T; A1298C; Myocardial infarction; Meta-analysis;
Chemotherapy-induced neurotoxicity in pediatric solid non-CNS tumor patients: An update on current state of research and recommended future directions
Keywords: ALL; acute lymphoblastic leukemia; APOE; apolipoprotein E; BDNF; brain-derived-neurotrophic-factor; BBB; blood-brain-barrier; CNS; central nervous system; GM; grey matter; HPA-axis; hypothalamus-pituitary-adrenal-axis; MTHFR; methylenetetrahydrofolate red
Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia
Keywords: 2-Methoxyestradiol; preeclampsia; COMT; genotype; MTHFR;
The MAOA, COMT, MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women
Keywords: MAOA; COMT; MTHFR; ESR1; Gene polymorphism; Menopausal depression
The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of Oran city
Keywords: MTHFR; 5,10-methylenetetrahydrofolate reductase; HTN; hypertension; SBD; systolic blood pressure; DBP; diastolic blood pressure; PCR; polymerase chain reaction; RFLP; restrictive fragment length polymorphism; EH; essential hypertension; HHcy; hyperhomocys
Supplémentation préconceptionnelle en acide folique / multivitamines pour la prévention primaire et secondaire des anomalies du tube neural et d'autres anomalies congénitales sensibles à l'acide folique
Keywords: Folic acid; folate; prenatal multivitamins; micronutrients; neural tube defect; spina bifida; myelomeningocele; congenital anomalies; fetal anomalies; folate sensitive birth defects; congenital anomaly risk reduction; preconception counseling; birth defec
Thioethers as markers of hydrogen sulfide production in homocystinurias
Keywords: Hydrogen sulfide; Cystathionine beta-synthase; Gamma-cystathionase; Homolanthionine; Cystathionine; Lanthionine; BSA; bovine serum albumin; CBS; cystathionine beta-synthase; CTH; gamma-cystathionase; Cys; cysteine; Cystat; cystathionine; H2S; hydrogen sul
Association of the MTHFR rs1801131 and rs1801133 variants in sporadic Parkinson's disease patients
Keywords: PD; Parkinson's disease; MAPT; the microtubule-associated protein tau gene; GBA; the glucocerebrosidase gene; SMPD1; the sphingomyelin phosphodiesterase 1, âacid lysosomal gene; MTHFR; the methylenetetrahydrofolate reductase gene; dbSNP; database of s
Genetic animal models to decipher the pathogenic effects of vitamin B12 and folate deficiency
Keywords: Vitamin B12; Folate; Methyl donor deficiency; Pathogenesis; Genetic animal models; B12; vitamin B12; SAM; S-adenosylmethionine; SAH; S-adenosylhomocysteine; HCY; homocysteine; KO; knock-out; ES cells; embryonic stem cells; OCM; one-carbon metabolism; NTD;
Association of MTHFR genetic variants C677T and A1298C on predisposition to spontaneous abortion in Slavonic population
Keywords: MTHFR; Polymorphism; Predisposition; Pregnancy loss; Spontaneous abortion
Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population
Keywords: THRGFs, thrombophilic genetic factors; HCC, hepatocellular carcinoma; PVT, portal vein thrombosisGenetic mutation; PAI-1; Plasminogen activator inhibitor-type 1; MTHFR C677T; MTHFR; Methylenetetrahydrofolate reductase; V Leiden 506Q; Prothrombin 20210A; P
Angiotensin converting enzyme and methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome
Keywords: FM; fibromyalgia syndrome; PCR; polymerase chain reaction; RFLP; restriction fragment length polymorphism; DED; dry eye disease; ACE; angiotensin converting enzyme; Hcy; homocysteine; ATII; angiotensin II; HPA; hypothalamic-pituitary-adrenal axis; eNO
Methylation analysis of multiple genes in blood DNA of Alzheimer’s disease and healthy individuals
Keywords: DNA methylation; Alzheimer’s disease; Folate; Homocysteine; Vitamin B12; PSEN1; BACE1; MTHFR; DNMTs; APOE
Methylenetetrahydrofolate reductase gene polymorphism in endometrial cancer: A systematic review and meta-analysis
Keywords: endometrial cancer; methylenetetrahydrofolate reductase; MTHFR; polymorphisms; risk
Effect of MTHFR, TGFβ1, and TNFB polymorphisms on osteoporosis in rheumatoid arthritis patients
Keywords: ACR; American College of Rheumatology; BMD; bone mineral density; CI; confidence interval; LTA; lymphotoxin alpha; MHC; major histocompatibility complex; MTHFR; methylene tetrahydrofolate reductase; OR; odds ratio; OP; osteoporosis; Ï2; Pearson chi squar
Methylenetetrahydrofolate Reductase Gene A1298C Polymorphism in Pediatric Stroke—Case–Control and Family-based Study
Keywords: Stroke; children; hyperhomocysteinemia; polymorphism; MTHFR; A1298C
Polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) are associated with susceptibility to adult acute myeloid leukemia in a Chinese population
Keywords: MTHFR; Polymorphism; AML; Risk;
The MTHFR C677T polymorphism contributes to increased risk of Alzheimer’s Disease: Evidence based on 40 case-control studies
Keywords: Alzheimer’s disease; MTHFR; C677T; Polymorphism; Meta-analysis
Original ResearchCyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia
Keywords: Homocysteine; Hyperhomocysteinemia; Folate; 5-Methyl-tetra-hydro-folate; Cyclic folate supplementation; Patient; HHcy; hyperhomocysteinemia; 5-MTHF; 5-methyltetrahydrofolate; MTHFR; methylenetetrahydrofolate reductase; tHcy; total homocysteine;
A NOS3 Polymorphism Determines Endothelial Response to Folate in Children with Type 1 Diabetes or Obesity
Keywords: BH4; Tetra-hydro biopterin; eNOS; Endothelial nitric oxide synthase (enzyme); eNOS4; Insertion/deletion polymorphism in intron 4 of endothelial nitric oxide synthase; FMD; Flow-mediated dilatation; GTN; Glyceryl trinitrate; MTHFR; Methylene tetrahydrofola
Coronary artery disease and the frequencies of MTHFR and PON1 gene polymorphism studies in a varied population of Hyderabad, Telangana region in south India
Keywords: MTHFR; PON1; ACE; Coronary artery disease; South Indian population