Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme
Keywords: PDK1 inhibitors; Kinase inhibitors; Oxindole derivatives; Glioblastoma; GBM stem cells; Multi-target therapy; PI3K; phosphatidylinositol-3-kinase; PDK1; phosphoinositide-dependent kinase-1; GSK3; Glycogen synthase kinase 3; CHK1; Checkpoint kinase-1; Akt;