Keywords: Biphalin; Opioid receptors; MOR/DOR/KOR agonist; Synergistic analgesic effect; Cyclic peptides; Acm; acetamidomethyl; ACN; acetonitrile; BBB; blood brain barrier; Boc; t-butyloxycarbonyl; BOP; (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluoro
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Synthesis and biological evaluation of cyclopeptide GG-8-6 and its analogues as anti-hepatocellular carcinoma agents
Keywords: HCC; hepatocellular carcinoma; MDP; muramyl dipeptide; SAR; structure and activity relationship; SPPS; solid phase peptide synthesis; MeOH; methanol; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; PI; propidium iodide; VP-16; etop
N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model
Keywords: AUCu; unbound area-under-the-curve; (S)-BINAP; (S)-(-)-(1,1â²-binaphthalene-2,2â²-diyl)bis(diphenylphosphine); CLu; unbound systemic clearance rate; Compd; compound; DIEA; N,N-diisopropyl ethylamine, EtOAc, ethyl acetate; FFA2 receptor; free fatty acid-
Synthesis and evaluation of novel ureido/thioureido derivatives of amino acid conjugated 2,3-dichlorophenyl piperazine as highly potent antiglycating agents
Keywords: AGE; advanced glycation end products; Boc; t-butoxycarbonyl; BSA; bovine serum albumin; EDCI; 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide·HCl; HOBt; 1-hydroxybenzotriazole; NMM; N-methyl morpholine; PBS; phosphate buffer saline; PZN; 1-(2,3-dichloroph
Implications of N-capped urea/thiourea and C-capped 3-(1-piperazinyl)-1,2-benzisothiazole with bridging Gly-Val/Phe-Gly-Val-Pro as therapeutic targets
Keywords: Peptides; Conjugation; Antimicrobial; Antiglycation; Urease inhibition; H+/K+-ATPase activity; ANSA; 1-amino-2-naphthol-4-sulphonic acid; Bis-PNPC; bis(4-nitrophenyl)carbonate; Boc; tert-butyloxycarbonyl; DCM; dichloromethane; EGTA; ethylene glycol tetraa
Catalytic promiscuity of a bacterial α-N-methyltransferase
Keywords: Dha; dehydroalanine; Dhb; dehydrobutyrine; Avi-Cys; S-[(Z)-2-aminovinyl]-cysteine; SAM; S-adenosylmethionine; SAH; S-adenosylhomocysteine; NRMT; N-terminal RCC1 methyltransferase; MCMC; Markov chain Monte Carlo; SPPS; solid phase peptide synthesis; DMF; d
Synthesis, structure, and biological aspects of cyclopeptides related to marine phakellistatins 7-9
Keywords: Cyclopeptides; Solid phase synthesis; Marine natural products; Cytotoxic; AcOH; acetic acid; AA; amino acid; DCM; dichloromethane; DIEA; diisopropylethylamine; DKP; diketopiperazine; DMEM; Dulbecco's modified Eagle's medium; DMF; N,N-dimethylformamide; ES