کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4909422 | 1362620 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and evaluation of novel ureido/thioureido derivatives of amino acid conjugated 2,3-dichlorophenyl piperazine as highly potent antiglycating agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and evaluation of novel ureido/thioureido derivatives of amino acid conjugated 2,3-dichlorophenyl piperazine as highly potent antiglycating agents Synthesis and evaluation of novel ureido/thioureido derivatives of amino acid conjugated 2,3-dichlorophenyl piperazine as highly potent antiglycating agents](/preview/png/4909422.png)
چکیده انگلیسی
We report the synthesis and in vitro antiglycation activity of more than 80 amino acid-heterocycle conjugate derived ureas and thioureas. They were characterized by physical and spectroscopical methods. Many of the analogues synthesized showed activity at the sub-micro molar level. Introduction of different amino acids as linker and systematic variation of the substituents on the aromatic ring revealed promising leads. In particular, compounds containing Glu and Tyr as the linkers exhibited high antiglycating potency with IC50 1-4 μM as against the reference, rutin with IC50 41.9 μM.ConclusionsCompounds bearing halogen atoms emerged as the most active analogues and serve as lead for future studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Saudi Chemical Society - Volume 21, Supplement 1, January 2017, Pages S248-S257
Journal: Journal of Saudi Chemical Society - Volume 21, Supplement 1, January 2017, Pages S248-S257
نویسندگان
D.M. Suyoga Vardhan, C.S. Shantharam, R. Suhas, D. Channe Gowda,