Keywords: Biphalin; Opioid receptors; MOR/DOR/KOR agonist; Synergistic analgesic effect; Cyclic peptides; Acm; acetamidomethyl; ACN; acetonitrile; BBB; blood brain barrier; Boc; t-butyloxycarbonyl; BOP; (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluoro
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Keywords: BOLD; blood oxygenation level-dependent; fMRI; functional magnetic resonance imaging; LG; lingual gyrus; MFG; Middle frontal gyrus; NM; negative match; NMM; negative mismatch; PM; positive match; PMM; positive mismatch; taste-visual cross-modality; confli
Keywords: Ac; acetyl; AD-mix; asymmetric dihydroxylation mix; ATP; adenosine triphosphate; Bn; benzyl; Boc; tert-butyloxycarbonyl; Bu; butyl (n-Bu, n-butyl; I; isobutyl; sec-Bu; sec-butyl; t-Bu; tert-butyl); Bz; benzoyl; CAL-B; Candida antartcia lipase-B; CAN; ceri
Keywords: CST; constant strain triangular [element]; DDA; discontinuous deformation analysis; ME; manifold element; NB; node-based uniform strain [element]; NMM; numerical manifold method; NMM-DDA; Elasto-plastic constitutive law; Node-based uniform strain element;
Keywords: CD; circular dichroism; CPE; cytopathic effect; DMF; dimethylformamide; FBS; fetal bovine serum; Fmoc; 9-fluorenylmethoxycarbonyl; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafluorophosphate; HOBt; N-hydroxybenzotriazole; HPLC; high perfor
Keywords: NMM; Finite cover system; Cracks; Integration cell; Tessellation approach
Keywords: Nitro compounds; Natural products; Pharmaceuticals; Stereoselective synthesis; Organocatalysis; Metal catalysis; Nitronates; Nitrile oxides; AIBN; azobisisobutyronitrile; AZADO; 2-azaadamantane-N-oxyl; 9-BBN; 9-borabicyclo[3.3.1]nonane; BINAP; 2,2â²-bis(
Keywords: MeCN; acetonitrile; CL; clearance; Dess-Martin periodinane; 1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1H)-one; DIBALH; diisobutylaluminum hydride; DMF; N,N-dimethylformamide; EtOAc; ethyl acetate; HBTU; N,N,Nâ²,Nâ²-tetramethyl-O-(1H-benzotr
Keywords: Abz; ortho-aminobenzoic acid; EDDnp; N-(2,4-dinitrophenyl)-ethylenediamine; FRET; fluorescence resonance energy transfer; hMIP; human mitochondrial intermediate peptidase; HOBt; hydroxybenzotriazole; TBTU; O-(benzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethylur
Keywords: Hyaluronan; Triazine Coupling; Amidation; Fractional-factorial design; Response surface methodology; 2-chloro-4,6-dimethoxy-1,3,5-triazine (PubChem CID: 18450); 4-methylmorpholine (PubChem CID: 7972); Cystamine dihydrochloride (PubChem CID: 5941); FF; fra
Keywords: AIBN; α,αâ²-azoisobutyronitrile; AmP-MCF; amino-functionalized mesocellular foam; AP-SiO2; silica functionalized with 3-aminopropyl groups; BCL; Burkholderia cepacia lipase; Bz; benzyl; CAL-A; Candida antarctica lipase A; CAL-B; Candida antarctica lipa
Keywords: EIAs; enzyme immunoassays; ELISAs; enzyme-linked immunosorbent assays; FRET; fluorescence resonance energy transfer; MB; molecular beacon; PNK; polynucleotide kinase; CAMB; catalytic and molecular beacon; ssDNA; single-stranded DNA; dsDNA; double-stranded
Keywords: SERT; serotonin transporter; NET; norepinephrine transporter; DAT; dopamine transporter; NSS; neurotransmitter/sodium (Na+/Clâ) symporter; SSRI; selective serotonin reuptake inhibitor; NBD; nitrobenzoxadiazolealanine; NMM; N-methylmorpholine; NHS; N-hyd
DNA sequence-specific ligands. XVII. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric bisbenzimidazoles DBA(n)
Keywords: topo-I; DNA topoisomerase I; DMT; DNA methyltransferase; HSV-1; herpes simplex virus type 1; CMV; cytomegalovirus; scDNA; supercoiled DNA; b.p.; base pairs; MABs; monoclonal antibodies; ACV; acyclovir; PBS; phosphate buffered saline; PFU/cells; plaque for
A numerical study of spalling and related rockburst under dynamic disturbance using a particle-based numerical manifold method (PNMM)
Keywords: NMM; Spalling; Rockburst; Dynamic disturbance; Stress wave propagation;
Synthesis and biological evaluation of cyclopeptide GG-8-6 and its analogues as anti-hepatocellular carcinoma agents
Keywords: HCC; hepatocellular carcinoma; MDP; muramyl dipeptide; SAR; structure and activity relationship; SPPS; solid phase peptide synthesis; MeOH; methanol; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; PI; propidium iodide; VP-16; etop
A zero-thickness cohesive element-based numerical manifold method for rock mechanical behavior with micro-Voronoi grains
Keywords: Random Voronoi polygon; Cohesive element; Mechanical response; NMM;
Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
Keywords: Astacins; Auxiliary enzyme; Continuous assay; Meprin α/β; Prolyl tripeptidyl aminopeptidase (PtP); AMC; 7-amido-4-methylcoumarin; Boc; tert-butyloxycarbonyl; DCM; dichloromethane; DMF; dimethylformamide; DTE; Dithioerythritol; HIC-EBA; hydrophobic inter
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity
Keywords: Antibacterial; DNA gyrase; GyrB; Inhibitor; N-phenylpyrrolamide; ParE; Topoisomerase IV; ATCC; American type culture collection; ATR; attenuated total reflectance; CDI; 1,1â²-carbonyldiimidazole; CFU; colony-forming unit; CLSI; Clinical and Laboratory St
N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model
Keywords: AUCu; unbound area-under-the-curve; (S)-BINAP; (S)-(-)-(1,1â²-binaphthalene-2,2â²-diyl)bis(diphenylphosphine); CLu; unbound systemic clearance rate; Compd; compound; DIEA; N,N-diisopropyl ethylamine, EtOAc, ethyl acetate; FFA2 receptor; free fatty acid-
Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship
Keywords: Cefiderocol; Siderophore; Siderophore cephalosporin; Multi-drug resistant Gram-negative pathogens; ESBL; extended-spectrum β-lactamase; MDR; multi-drug resistant; PG; protecting group; ACLE·HCl; (7-amino-3-chloromethyl-3-cephem-4-carboxylate p-methoxybe
Phenylglycine racemization in Fmoc-based solid-phase peptide synthesis: Stereochemical stability is achieved by choice of reaction conditions
Keywords: COMU; (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium hexafluorophosphate; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DEPBT; 3-diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethyl
Synthesis and biological evaluation of Santacruzamate-A based analogues
Keywords: AcCN; acetonitrile; BnOH; benzyl alcohol; DMF; N,N-dimethylformamide; DMSO; dimethylsulphoxide; EtOAc; ethyl acetate; EtOH; ethanol; GABA; γ-aminobutyric acid; GADPH; glyceraldehyde 3-phosphate dehydrogenase; HBTU; O-(benzotriazol-1-yl)-N,N,Nâ²,Nâ²-tet
Substituted α-mercaptoketones, new types of specific neprilysin inhibitors
Keywords: BTFA; boron trifluoroacetate; DIEA; diisopropylethylamine; EtOH; ethanol; HPLC; High Performance Liquid Chromatography; LC/MS; Liquid Chromatography/Mass Spectroscopy; LDA; lithium diisopropyl amide; NEP; neprilysin; NMM; N-methylmorpholine; PMBSH; para-m
Synthesis and evaluation of novel ureido/thioureido derivatives of amino acid conjugated 2,3-dichlorophenyl piperazine as highly potent antiglycating agents
Keywords: AGE; advanced glycation end products; Boc; t-butoxycarbonyl; BSA; bovine serum albumin; EDCI; 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide·HCl; HOBt; 1-hydroxybenzotriazole; NMM; N-methyl morpholine; PBS; phosphate buffer saline; PZN; 1-(2,3-dichloroph
Bivalent SIRT1 inhibitors
Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; NAM; nicotinamide; 2â²-O-AADPR; 2â²-O-acyl-ADP-ribose; RP-HPLC; reversed-phase high performance liquid chromatography; HRMS; high-resolution mass spectrometry; EDC-MeI; 1-(3-dimethylaminopropyl)-3-ethylcarb
G-quadruplex formation in the Oct4 promoter positively regulates Oct4 expression
Keywords: ESC; embryonic stem cells; CSC; cancer stem cells; PQS; potential quadruplex-forming site; NMM; N-methyl mesoporphyrin IX; Guanine quadruplex; Oct4; Transcription regulation; Circular dichroism; Luciferase reporter; Human embryonic stem cells;
Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells
Keywords: Neural induction; Neural progenitor cells; hiPSC; Electron microscopy; Patch clamp; 2D-3D neural induction; AD; Alzheimer's disease; AQP4; Aquaporin 4; ASD; Autism spectrum disorder; bFGF; Basic Fibroblast Growth Factor; CNS; Central Nervous System; D; Da
Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine
Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; MBHA; 4-methylbenzhydrylamine; SPPS; solid phase peptide synthesis; DMF; N,N-dimethylformamide; TFA; trifluoroacetic acid; DCM; dichloromethane; HBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexa
Brain (Hyper)Excitability Revealed by Optimal Electrical Stimulation of GABAergic Interneurons
Keywords: Neurostimulation; Electrical; Extracellular bipolar direct stimulation; Neuronal network; Excitability; GABAergic interneuron; Local field potential; Depth-EEG; Computational model; In vivo; In vitro; Epilepsy; ELBS; extracellular, local, bipolar stimulat
Novel double prodrugs of the iron chelator N,Nâ²-bis(2-hydroxybenzyl)ethylenediamine-N,Nâ²-diacetic acid (HBED): Synthesis, characterization, and investigation of activation by chemical hydrolysis and oxidation
Keywords: Iron; Double prodrug; Prochelator; Oxidative stress; Boronic acid; Chelation therapy; ROS; reactive oxygen species; DFO; desferrioxamine B; HBED; N,Nâ²-bis(2-hydroxybenzyl)ethylenediamine-N,Nâ²-diacetic acid; NMM; N-methylmorpholine; EDTA; ethylenediami
Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei
Keywords: Mip; macrophage infectivity potentiator; PPIase; peptidyl-prolyl cis/trans isomerase; LpMip; L. pneumophila Mip; BpMip; B. pseudomallei Mip; SAR; structure-activity relationship; HSQC; Heteronuclear Single Quantum Coherence; NMM; N-methylmorpholine; DIP
Structure-activity relationship study using peptide arrays to optimize Api137 for an increased antimicrobial activity against Pseudomonas aeruginosa
Keywords: Apidaecin; Gram-negative bacterium; Proline-rich antimicrobial peptide (PrAMP); Pseudomonas aeruginosa; SPOT synthesis; AMP; antimicrobial peptide; DIC; N,Nâ²-diisopropylcarbodiimide; DIPEA; N-ethyldiisopropylamine; DMAP; 4-dimethylaminopyridine; gu; N,N
Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists
Keywords: Residence time; Structure-affinity relationships; Structure-kinetics relationships; Adenosine A1 receptor; Extracellular loops; ADA; adenosine deaminase; Ac; acetyl; BCA; bicinchoninic acid; BEDROC; Boltzmann-enhanced discrimination of receiver-operating
Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins
Keywords: Blood-brain barrier (BBB) transport (influx/efflux); Antinociceptive activity; Linear/cyclic enkephalin analogs; In vivo mouse models; AUC; area under the curve; Alloc; allyloxycarbonyl; BBB; blood-brain barrier; Boc; tertButyloxycarbonyl; BSA; bovine
Chimeric derivatives of functionalized amino acids and α-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels
Keywords: AAA; α-aminoamide; ASD; antiseizure drug; ASP; Anticonvulsant Screening Program; CAD; catecholamine A-differentiated; CNS; central nervous system; ED50; effective dose (50%); FAA; functionalized amino acid; IBCF; isobutyl chloroformate; IC50; concentrati
Implications of N-capped urea/thiourea and C-capped 3-(1-piperazinyl)-1,2-benzisothiazole with bridging Gly-Val/Phe-Gly-Val-Pro as therapeutic targets
Keywords: Peptides; Conjugation; Antimicrobial; Antiglycation; Urease inhibition; H+/K+-ATPase activity; ANSA; 1-amino-2-naphthol-4-sulphonic acid; Bis-PNPC; bis(4-nitrophenyl)carbonate; Boc; tert-butyloxycarbonyl; DCM; dichloromethane; EGTA; ethylene glycol tetraa
Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation
Keywords: ALS; amyotrophic lateral sclerosis; AMC; 7-amido-4-methylcoumarin; z-ARR-AMC; z-Ala-Arg-Arg-amido-4-methylcoumarin; ChT-L; chymotrypsin-like proteasomal activity; DMF; N,N-dimethyl formamide; DMSO; dimethyl sulfoxide; DNPH; 2,4-dinitrophenylhydrazine; DTT
Organization of the orexin/hypocretin system in the brain of two basal actinopterygian fishes, the cladistians Polypterus senegalus and Erpetoichthys calabaricus
Keywords: Orexins; Tyrosine hydroxylase; Serotonin; Immunohistochemistry; Hypothalamus; Polypteridae; Brain evolution; ac; anterior commissure; aCb; cerebellar auricle; cCb; crista cerebellaris; Cb; cerebellum; cc; central canal; Cg; central gray; DF; dorsal funicu
A label-free biosensor for DNA detection based on ligand-responsive G-quadruplex formation
Keywords: Label-free; NMM; G-quadruplex; DNA detection;
Synthetic tripeptides as alternate substrates of murein peptide ligase (Mpl)
Keywords: Escherichia coli; Mpl; Murein peptide ligase; Peptidoglycan recycling; Tripeptide substrates; Abu; 2-aminobutyric acid; AcOH; acetic acid; Apm; 2-aminopimelic acid; A2pm; 2,6-diaminopimelic acid; Bn; benzyl; Boc; t-butyloxycarbonyl; DCC; N,Nâ²-dicyclohex
New α-adrenergic property for synthetic MTβ and CM-3 three-finger fold toxins from black mamba
Keywords: Muscarinic toxin; Muscarinic receptor; Adrenergic toxin; Adrenoceptor; Three-finger fold toxin; GPCRs; GPCR; G-protein coupled receptor; mAChRs; muscarinic acetylcholine receptors; MTs; muscarinic toxins; NMS; N-methylscopolamine; HCTU; 2-(6-Chloro-1H-ben
The pro-apoptotic action of new analogs of the insect gonadoinhibiting peptide Neb-colloostatin: Synthesis and structure-activity studies
Keywords: Ach; 1-aminocyclohexane-1-carboxylic acid; Acp; 1-aminocyclopentane-1-carboxylic acid; CD; circular dichroism; DMF; dimethylformamide; EDT; 1,2-ethanedithiol; Fmoc; 9-fluorenylmethoxycarbonyl; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafl
Linear and cyclic glycopeptide as HIV protease inhibitors
Keywords: HIV-1 protease; Linear and cyclic glycopeptides; Solid and solution peptide synthesis; Molecular docking; AIDS; acquired immunodeficiency syndrome; CTC; 2-chlorotrityl chloride; DCM; dichloromethane; DIPEA; N,N-diisopropyl ethylamine; DMF; N,N-dimethylfor
Proteasome inhibitors for cancer therapy
Keywords: BOP; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; DMSO; dimethyl sulfoxide; HMPA; hexamethyl phosphoramide; HOBt; 1-hydroxybenzotriazole; NMM; N-methylmorpholine; DMF; N,N-dimethyformamide; LDA; lithium diisopropylamide; THF;
Catalytic promiscuity of a bacterial α-N-methyltransferase
Keywords: Dha; dehydroalanine; Dhb; dehydrobutyrine; Avi-Cys; S-[(Z)-2-aminovinyl]-cysteine; SAM; S-adenosylmethionine; SAH; S-adenosylhomocysteine; NRMT; N-terminal RCC1 methyltransferase; MCMC; Markov chain Monte Carlo; SPPS; solid phase peptide synthesis; DMF; d
Study of intramolecular aminolysis in peptides containing N-alkylamino acids at position 2
Keywords: Peptides; Intramolecular aminolysis; Nα-Alkylamino acids; 2,5-Diketopiperazines; Endopeptolysis; Methionine-S-oxide; Ahx; aminocyclohexanoic acid; EtPhe(4-F); N-ethyl-4-fluorophenylalanine; HOSu; N-hydroxysuccininide; IA; intramolecular aminolysis; NMM;
Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates
Keywords: Kinin; Protease; Histatins; Kosmotropic salts; Myelin basic protein; Q-EDDP; (glutamyl-N-[ethylenediamine] 2,4-dinitrophenyl); Abz; ortho-aminobenzoic acid; HOBt; N hydroxybenzotriazole; TBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluo
Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule: The HIV-1 CD4:gp120 paradigm
Keywords: AcOH; acetic acid; Alloc; allyloxycarbonyl; Boc; t-butoxycarbonyl; BTC; bis(trichloromethyl)carbonate; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM; methylene chloride; DIC; N,Nâ²-diisopropylcarbodiimide; DIPEA; diisopropylethylamine; DMAP; dimethylamino
Positively charged amino acids flanking a sumoylation consensus tetramer on the 110Â kDa tri-snRNP component SART1 enhance sumoylation efficiency
Keywords: Bis-Tris; 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol; E1; SUMO activating enzyme; E2; SUMO protein carrier protein; E3; SUMO ligase; Fmoc; 9H-fluorenylmethyloxycarbonyl; IPTG; isopropyl-β-D-thiogalactopyranoside; NMM; N-methylmorpholi